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Thin-layer composite tissue repair material with stable mechanical property and preparation method thereof

A technology of composite tissue and repair materials, applied in medical science, prosthesis, etc., can solve the problems of bacterial colonization, infection, and incomplete fit, etc., and achieve the effect of mild tissue reaction, good biocompatibility, and good integrity.

Inactive Publication Date: 2017-09-29
EXCELLENCE MEDICAL TECH SUZHOU CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanical reinforcement layer of this composite soft tissue repair material is a braided structure, the surface of the fiber is smooth and there are cavities at the braided knots, which cannot completely fit with the upper and lower surface layers, which may easily lead to bacterial colonization and infection.

Method used

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  • Thin-layer composite tissue repair material with stable mechanical property and preparation method thereof
  • Thin-layer composite tissue repair material with stable mechanical property and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The pig small intestinal submucosa extracellular matrix (SIS) was prepared by the Abraham method, and the single-piece membrane-like SIS was spliced ​​into a larger-area sheet according to the dislocation between the layers, and three layers were tiled, and they were bonded together with medical adhesives , for the upper and lower surface layers. The porosity is 80%, the average pore size is 10μm, and the mass is 30g / m 2 electrospun fabric. like figure 1 Place the upper and lower surface layers (1) and the electrospun cloth (2) in sequence, and the mass ratio of the upper and lower surface layers to the electrospun cloth is 10:1. Bond the three with medical adhesive, and then press them together with a certain pressure.

Embodiment 2

[0029] The single film-like SIS is spliced ​​into larger-area sheets according to the dislocation between layers, three layers are tiled, and the upper and lower surface layers are bonded together with medical adhesives. The square hole is 1cm long, the hole spacing is 1mm, and the mass is 30g / m 2 brushed polypropylene film. like figure 2 Place the upper and lower surface layers (1) and the film (2) in sequence, and the mass ratio of the upper and lower surface layers to the film is 10:1. Bond the three with medical adhesive, and then press them together with a certain pressure.

Embodiment 3

[0031] According to the national standard GB / T528-2009, five samples of each of Example 1 and Example 2 were made into a 5cm×1cm dumbbell shape, and the two ends of the sample were fixed with a material mechanics testing machine, stretched at a speed of 10mm / min, and the material resistance was measured. The tensile strengths were 63±7N / cm and 54±5N / cm respectively.

[0032] Construct an animal model of canine rectus abdominis partially layered defect with local high pressure (a water bladder is added between the posterior sheath of the rectus abdominis and the repair material), and the defect area is 10×5cm2 , the composite biological patch was cut to a certain size for repair, and the tension was increased to 40mmHg by injecting water into the water bag monthly after the operation. It was observed that there was no abdominal wall bulge in the repaired area at 24 months; the tissue in the repaired area was taken out at 24 months after the operation, and the mechanical strength ...

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Abstract

The invention relates to a thin-layer composite tissue repair material with stable mechanical property and a preparation method thereof. The composite material is formed by compounding a nonwoven material or a porous synthetic membrane as a mechanical stability layer, and three-dimensional network structure diaphragm materials as upper and lower surface layers. The thin-layer composite tissue repair material is capable of significantly improving the mechanical strength of the three-dimensional network structure diaphragm material on the premise of not obviously improving the overall thickness of the composite tissue repair material, has long-term mechanical stability, and is free of a dead space, free of a colonization space for bacteria, good in biosecurity and wide in clinical application prospect.

Description

technical field [0001] The invention belongs to the field of tissue repair materials and preparation thereof, in particular to a thin-layer composite tissue repair material with stable mechanical properties and a preparation method thereof. Background technique [0002] Biomaterials have been widely used in the field of soft tissue repair in the past decade. Compared with the long-term chronic inflammatory stimulation and susceptibility to bacterial colonization and chronic infection caused by synthetic materials, biomaterials can induce endogenous regeneration after implantation in the body. , has the advantages of being completely degradable, resistant to infection and infection. However, there are still controversies in clinical application. One of them is that the products made of extracellular matrix materials have a relatively fast degradation time in vivo and cannot be completely remodeled with the tissue. Difference. [0003] Therefore, in order to delay the materi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/50A61L27/56
Inventor 张剑程文悦
Owner EXCELLENCE MEDICAL TECH SUZHOU CO LTD
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