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Fe-based metal organic skeleton nanoparticles with function of near-infrared absorption, and preparation method of Fe-based metal organic skeleton nanoparticles

An organic framework and nanoparticle technology, which is applied in the field of preparation of near-infrared photothermal conversion nano-functional materials, and achieves the effects of excellent photothermal conversion effect, simple and easy-to-operate process, and uniform particle size.

Inactive Publication Date: 2017-09-29
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, people have successfully designed and synthesized more than 20,000 kinds of MOFs bulk, thin film and nanomaterials in methanol, dimethylformamide (DMF), water and other solutions by changing metal ions, organic bridging ligands and synthesis conditions. There are few reports on MOFs materials with near-infrared absorption properties

Method used

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  • Fe-based metal organic skeleton nanoparticles with function of near-infrared absorption, and preparation method of Fe-based metal organic skeleton nanoparticles
  • Fe-based metal organic skeleton nanoparticles with function of near-infrared absorption, and preparation method of Fe-based metal organic skeleton nanoparticles
  • Fe-based metal organic skeleton nanoparticles with function of near-infrared absorption, and preparation method of Fe-based metal organic skeleton nanoparticles

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Effect test

Embodiment 1

[0028] Preparation of iron-based metal-organic framework nanoparticles with remarkable near-infrared absorption properties

[0029] First, dissolve 1.32 grams of potassium ferricyanide in 33.68 milliliters of deionized water, and stir to obtain an aqueous solution of potassium ferricyanide; then, under rapid stirring, add 6 milliliters of molecular weight to the aqueous solution of potassium ferricyanide Be 40000 polyvinylpyrrolidone solution, 0.32 milliliter hydrochloric acid solution; Wherein the final concentration of potassium ferricyanide, polyvinylpyrrolidone, hydrochloric acid is 0.05 mol / liter, 0.75 mol / liter, 0.1 mol / liter; Obtain preparation iron after stirring for 30 minutes The precursor solution of metal-organic framework nanoparticles, and finally the obtained precursor solution was placed in an oven at 75 degrees Celsius for 24 hours to obtain a blue iron-based metal-organic framework nanoparticle solution; after the reaction was completed, the obtained The iron...

Embodiment 2

[0031] Preparation of Iron-based Metal-Organic Framework Nanoparticles at Different Reaction Temperatures

[0032] Take four 50ml centrifuge tubes and mark them as A, B, C, and D respectively, and then add 33.68ml of deionized water and 1.32g of ferricyanide to the centrifuge tubes A, B, C, and D respectively under the condition of rapid stirring. Potassium, 6 milliliters of molecular weight are the polyvinylpyrrolidone solution of 40000, 0.32 milliliters of hydrochloric acid solution; Wherein A, B, C, the final concentration of potassium ferricyanide, polyvinylpyrrolidone, hydrochloric acid in the centrifuge tubes of D are 0.05 mol / L, 0.75 mol / L, 0.1 mol / L; after stirring for 30 minutes, the precursor solution for preparing iron-based metal-organic framework nanoparticles was obtained, and finally the precursor solutions in centrifuge tubes A, B, C, and D were placed at 40, 60, and 80 , and react in an oven at 100 degrees Celsius for 24 hours to obtain a blue iron-based meta...

Embodiment 3

[0034] Preparation of Iron-based Metal-Organic Framework Nanoparticles under Different Conditions of Potassium Ferricyanide Concentration

[0035] Take four 50ml centrifuge tubes and mark them as A, B, C, and D respectively. Add 33.68ml of deionized water and 6ml of polystyrene with a molecular weight of 40,000 to the centrifuge tubes A, B, C, and D under rapid stirring. Vinylpyrrolidone solution, 0.32ml hydrochloric acid solution, then add 0.328, 1.32, 1.92, 2.624 grams of potassium ferricyanide to centrifuge tubes A, B, C and D respectively; The concentrations of potassium were 0.01, 0.1, 0.15, and 0.2 mol / L, respectively, and the concentrations of polyvinylpyrrolidone and hydrochloric acid were both 0.75 mol / L and 0.1 mol / L; after stirring for 30 minutes, the precursor for preparing iron-based metal-organic framework nanoparticles was obtained Finally, place the obtained precursor solution in an oven at 75 degrees Celsius to react for 24 hours to obtain a blue iron-based me...

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Abstract

The invention relates to Fe-based metal organic skeleton nanoparticles with a function of near-infrared absorption, and a preparation method of the Fe-based metal organic skeleton nanoparticles. The obtained Fe-based metal organic skeleton nanoparticles are characterized in that the nanoparticles belong to a porous structure material which is uniform in size and adjustable in scale and morphology and has larger specific surface area, remarkable near infrared absorption characteristic and good photothermal conversion effect. The preparation method comprises the steps of (1) sequentially adding a certain amount of a polyvinylpyrrolidone water solution and a certain amount of a hydrochloric acid solution into a potassium ferricyanide water solution under the stirring condition; (2) after 30min, placing a precursor solution obtained in the step (1) into a drying oven at the temperature of 40-100 DEG C for reacting for 24h; (3) carrying out high-speed centrifugal separation on a colloidal solution obtained in the step (2), and then carrying out ultrasonic cleaning to obtain the blue Fe-based metal organic skeleton nanoparticles. The obtained Fe-based metal organic skeleton nanoparticles have important potential application value in the aspects such as drug transport, diagnostic imaging, photothermal therapy and medicine controlled release.

Description

technical field [0001] The discovery relates to a Fe-based metal-organic framework nanoparticle with near-infrared absorption and a preparation method thereof, belonging to the field of preparation of near-infrared photothermal conversion nano-functional materials. Background technique [0002] In recent years, based on the fact that near-infrared light of 700-1000 nanometers has a high penetration depth in the human body, researchers have developed tumor photothermal therapy technology using nano-photothermal agents. Compared with traditional tumor treatment methods, photothermal therapy has the advantages of fast, efficient, minimally invasive, and less toxic and side effects, so it has attracted the attention of researchers at home and abroad in recent years. The basic principle of this method is to use targeted recognition technology to gather photothermal conversion materials near the tumor tissue, convert light energy into heat energy through near-infrared laser irradi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K47/32A61K47/02A61K41/00
CPCA61K9/0002A61K41/0052A61K47/02A61K47/32C08G83/008
Inventor 段中尧李村成张垒韦云威王俊暖徐波
Owner UNIV OF JINAN
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