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Thymopentin soluble microneedle and preparation method thereof

A soluble and thymic technology, applied in the direction of microneedles, needles, pharmaceutical formulations, etc., to reduce pain and inconvenience, prolong shelf life, and small diameter

Active Publication Date: 2020-01-07
GUANGZHOU NEWORLD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, improving the mechanical strength of dissolvable microneedles to effectively pierce the stratum corneum to create micropores for drug delivery is still a major problem in the development of microneedle preparations.

Method used

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  • Thymopentin soluble microneedle and preparation method thereof
  • Thymopentin soluble microneedle and preparation method thereof
  • Thymopentin soluble microneedle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The preparation of embodiment 1 Thymopentin soluble microneedles

[0050] This embodiment carries out the preparation of high-dose Thymopentin soluble microneedle (TP5-BSA-DMNA-H), its tip shape is conical, the height of the tip is 800 μm, the bottom of the tip is a circle with a diameter of 300 μm, adjacent The distance between the tops of the cones of the two needle tips is 900 μm, and the base is a square with a side length of 1 cm. The preparation of the soluble microneedle comprises the following steps:

[0051] 1. Preparation of needle tip solution

[0052] Precisely weigh 0.2501g of biodegradable material (Dex 40), 0.1000g of BSA, and 0.1000g of thymopentin raw drug, add 1mL of water, stir and dissolve to obtain a uniform viscous aqueous solution, namely the needle tip solution.

[0053] 2. Preparation of base solution

[0054] Accurately weigh 1.0002 g of high molecular weight polymer (PVPK90), add 2.5 mL of ethanol, stir evenly and let it swell overnight to ...

Embodiment 2

[0060] The preparation of embodiment 2 thymopentin soluble microneedles

[0061] In this example, a medium-dose Thymopentin soluble microneedle (TP5-BSA-DMNA-M) was prepared. The shape of the tip is conical, the height of the tip is 800 μm, and the bottom of the tip is a circle with a diameter of 300 μm. The distance between the tops of the cones of the two needle tips is 900 μm, and the base is a square with a side length of 1 cm. The preparation of the soluble microneedle comprises the following steps:

[0062] 1. Preparation of needle tip solution

[0063] Precisely weigh 0.2501g of biodegradable material (Dex 40), 0.1000g of BSA, and 0.0500g of thymopentin raw drug, add 1mL of water, stir and dissolve to obtain a uniform viscous aqueous solution, namely the needle tip solution.

[0064] 2. Preparation of base solution

[0065] Accurately weigh 1.0000 g of high molecular weight polymer (PVPK90), add 2.5 mL of ethanol, stir evenly and let it swell overnight to obtain the ...

Embodiment 3

[0071] Example 3 Preparation of Thymopentin Soluble Microneedles

[0072] This embodiment carries out the preparation of low-dose thymopentin soluble microneedles (TP5-BSA-DMNA-L). The distance between the tops of the cones of the two needle tips is 900 μm, and the base is a square with a side length of 1 cm. The preparation of the soluble microneedle comprises the following steps:

[0073] 1. Preparation of needle tip solution

[0074] Precisely weigh 0.2501g of biodegradable material (Dex 40), 0.1000g of BSA, and 0.0100g of thymopentin raw drug, add 1mL of water, stir and dissolve to obtain a uniform viscous aqueous solution, namely the needle tip solution.

[0075] 2. Preparation of base solution

[0076] Accurately weigh 1.0001 g of high molecular weight polymer (PVPK90), add 2.5 mL of ethanol, stir evenly and let it swell overnight to obtain the base solution.

[0077] 3. Preparation of soluble microneedle drug-containing needle tip

[0078] Take an appropriate amoun...

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Abstract

The invention relates to a soluble thymopentin microneedle and a preparation method thereof. The soluble thymopentin microneedle comprises a needle tip and a substrate, wherein the needle tip is prepared from a water solution of a biodegradable material, bovine serum albumin and thymopentin in a mass ratio of 25 to (3-15) to (0.5-15); and the biodegradable material is selected from at least one of dextran, polyvinylpyrrolidone, polyvinyl alcohol, hyaluronic acid, carboxymethylcellulose and dihydrate-D-trehalose. By adding the bovine serum albumin into the needle tip material to prepare the soluble thymopentin microneedle, the mechanical strength of the needle tip can be improved, so that the problems that the needle tip of an existing soluble thymopentin microneedle is low in mechanical strength and a percutaneous drug delivery pore cannot be formed are effectively solved; and by adding the bovine serum albumin, the drug carrying quantity of a drug in the needle tip can be further increased, and the drug content of the needle tip part of the microneedle can be effectively increased.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a thymopentin-soluble microneedle and a preparation method thereof. Background technique [0002] Thymopentin (TP5) has all the same biological activities as thymus auxin, and has a two-way regulatory effect on the immune function of the body. Aging effect. It can selectively induce the transformation of Thy-1 prothymocytes into Thy-1 T cells by increasing the level of intracellular cAMP, activate or regulate the number and function of different T cell subsets, and finally achieve a two-way effect on the entire body's immune system Regulation has been widely used clinically. Thymopentin is mainly used in the treatment of various malignant tumors (such as lymphoma) and postoperative infection and complications, diabetes and various chronic complications caused by it, chronic hepatitis (such as hepatitis C, viral hepatitis combined with biliary tract Infectio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/42A61K47/10A61K38/08A61P37/02A61M37/00
CPCA61K9/0021A61K38/08A61K47/10A61K47/42A61M37/0015A61M2037/0023A61M2037/0053
Inventor 吴传斌林师麒权桂兰潘昕蔡炳贞侯嫒琳杨佩佩
Owner GUANGZHOU NEWORLD PHARMA CO LTD
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