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Injectable hydrogel and its preparation and application

A technology for injecting water and hydrogel, which is applied in the direction of non-active ingredient medical preparations, prostheses, aerosol delivery, etc., to achieve the effect of easy adjustment, overcoming safety hazards, and controllable slow-release effect

Active Publication Date: 2020-02-14
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported in the literature that gels and microgels composed of phenylboronic acid and poly(N-isopropylacrylamide) (PNIPAM) can swell and release insulin in the presence of glucose, but these materials can only be used above the pKa of phenylboronic acid. It has glucose responsiveness only at pH 9 and higher glucose concentration (20g / L), which limits its application under physiological conditions (pH 7.4, glucose concentration 1-3g / L) (Synthesis and Volume Phase Transitions of Glucose-Sensitive Microgels, Biomacromolecules 2006, 7, 3196-3201, Phenylboronic acid-based glucose-responsive polymeric nanoparticles: synthesis and applications in drug delivery, Polym.Chem., 2014, 5, 1503-1518)

Method used

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  • Injectable hydrogel and its preparation and application
  • Injectable hydrogel and its preparation and application
  • Injectable hydrogel and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]Add 0.5 g of butyraldehyde-polyethylene glycol-butyraldehyde (m=100) and 1 g of four-arm terminal amino-modified polyethylene glycol (n=1000, Laysan) to 28.5 g of sterile deionized water, and shake rapidly at 37°C Mix well, and after 35 seconds, 30 g of injectable hydrogel in a transparent and uniform state are obtained.

[0036] The scanning electron microscope image of the injectable hydrogel is shown in figure 1 , showing that the hydrogel has a porous and dense structure with a pore size of 0.1mm-0.4mm.

Embodiment 2

[0038] Add 5g of butyraldehyde-polyethylene glycol-butyraldehyde (m=16000) and 1g of four-arm terminal amino-modified polyethylene glycol (n=5000, Laysan) to add 34g of disodium hydrogen phosphate-citric acid buffer (pH= 6.5), at 37°C, oscillate quickly and mix evenly, and after 30 seconds, 40 g of injectable hydrogel in a transparent and uniform state is obtained.

[0039] The scanning electron microscope image of the obtained injectable hydrogel shows that the hydrogel has a porous and dense structure with a pore diameter of 0.1mm-0.3mm.

Embodiment 3

[0041] 14g butyraldehyde-polyethylene glycol-butyraldehyde (m=10000) and polyethylene glycol (n=5700, Laysan) of 1g four-arm terminal amino-modification are added 85g disodium hydrogen phosphate-sodium dihydrogen phosphate buffer solution ( pH=7.4), 37° C., oscillating rapidly and mixing evenly, and after 25 seconds, 100 g of injectable hydrogel in a transparent and uniform state was obtained.

[0042] The scanning electron microscope image of the obtained injectable hydrogel shows that the hydrogel has a porous and dense structure with a pore diameter of 0.1mm-0.3mm.

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Abstract

The invention discloses injectable hydrogel and a preparation method and application thereof. The injectable hydrogel is composed of a raw material A, a raw material B and gelling liquid, a mass sum of the raw material A and the raw material B accounts for 5-50% of mass of the hydrogel, the raw material A is butyraldehyde-polyethylene glycol-butyraldehyde, and the raw material B is four-arm-terminated amino modified polyethylene glycol. The injectable hydrogel is obtained by mainly utilizing imide dynamic bonds formed by amino of four-arm-terminated amino modified polyethylene glycol and aldehyde of butyraldehyde-polyethylene glycol-butyraldehyde. The injectable hydrogel can be applied as a drug carrier, an embolization material or a tissue engineering material. The preparation method includes steps: adding the gelling liquid into the raw material A and the raw material B, and well mixing to obtain the injectable hydrogel. The injectable hydrogel has the advantages of simple, convenient and quick preparation process and easiness in large-scale production.

Description

technical field [0001] The invention belongs to the technical field of biomolecular medicine, and in particular relates to an injectable hydrogel and its preparation and application. Background technique [0002] Hydrogel is a three-dimensional network structure cross-linked by polymers, and has a wide range of applications in biomedical fields such as drug release, tissue engineering, and biosensing. Injectable in situ gel systems have received extensive attention in minimally invasive medicine and injectable tissue engineering. The gel matrix mixes biomolecules or cells in the solution before injection, and the scaffold material loaded with biomolecules or cells can be implanted into the desired site after injection. After gelation, it becomes the drug release base or The cell growth basis of tissue regeneration avoids the pain and cumbersomeness of surgical implantation, and in situ cell fixation is also conducive to filling an irregular tissue defect. [0003] At prese...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/52A61L27/26A61L31/14A61L31/04A61K9/06A61K47/10
CPCA61K9/0002A61K9/0019A61K9/06A61K47/10A61L27/26A61L27/52A61L31/041A61L31/145A61L2400/06A61L2430/36C08L71/02
Inventor 谭回李维平黄贤键黄国栋刘文兰
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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