Gel material for efficient treatment of tumors and preparation method thereof
A gel material and high-efficiency technology, applied in the field of medical nano-biomaterials, can solve the problems of body function of patients with toxic and side effects, physical and mental trauma of patients, failure to effectively suppress cancer mortality, etc., and achieve safe treatment and efficient responsive enzyme-catalyzed reaction. Effect
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Embodiment 1
[0047] A furan functionalized composite macroscopic hydrogel is prepared by the following method:
[0048] (1) Dissolve 0.5g of Fmoc-Lys-OH in 2mL THF and 1mL 1M NaHCO 3 In the mixed solvent, cool in an ice-water bath, then add 0.26g of furoyl chloride dropwise, react at room temperature overnight, add 10mL of dichloromethane, wash with dilute hydrochloric acid solution of pH = 2-3, distilled water and saturated saline, and then use anhydrous sulfuric acid Drying over sodium, spinning off dichloromethane to obtain a light yellow to colorless viscous liquid, drying under vacuum at room temperature overnight to obtain a light yellow fluffy flake solid, purified by column chromatography, the eluent is ethyl acetate and petroleum ether (v:v =1:6), the lysine derivative Fmoc-Lys(furoyl)-OH was obtained.
[0049] (2) Dissolve 0.05 g of glycol chitosan (GC) in 10 mL of DMSO, stir overnight, add dropwise 0.066 g of furoic acid and 0.21 g of BOP in DMSO (1 mL), and place the resulting...
Embodiment 2
[0059] A furan functionalized composite macroscopic hydrogel is prepared by the following method:
[0060] (1) Dissolve 0.3g of Fmoc-Lys-OH in 3mL THF and 0.8mL 1M NaHCO 3 In the mixed solvent, cool in an ice-water bath, then add 0.2 g of furoyl chloride dropwise, react overnight at room temperature, add 8 mL of dichloromethane, wash with dilute hydrochloric acid solution of pH = 2-3, distilled water and saturated saline, and then wash with anhydrous sulfuric acid Drying over sodium, spinning off dichloromethane to obtain a light yellow to colorless viscous liquid, drying under vacuum at room temperature overnight to obtain a light yellow fluffy flake solid, purified by column chromatography, the eluent is ethyl acetate and petroleum ether (v:v =1:6), the lysine derivative Fmoc-Lys(furoyl)-OH was obtained.
[0061] (2) Dissolve 0.03 g of glycol chitosan (GC) in 8 mL of DMSO, stir overnight, add dropwise 0.06 g of furoic acid and 0.15 g of BOP in DMSO (1 mL), and place the res...
Embodiment 3
[0065] A furan functionalized composite macroscopic hydrogel is prepared by the following method:
[0066] (1) Dissolve 0.8g of Fmoc-Lys-OH in 5mL THF and 1.2mL 1M NaHCO 3 In a mixed solvent, cool in an ice-water bath, then dropwise add 0.3g of furoyl chloride, react overnight at room temperature, add 12mL of dichloromethane, wash with dilute hydrochloric acid solution of pH = 2-3, distilled water and saturated saline, and then wash with anhydrous sulfuric acid Drying over sodium, spinning off dichloromethane to obtain a light yellow to colorless viscous liquid, drying under vacuum at room temperature overnight to obtain a light yellow fluffy flake solid, purified by column chromatography, the eluent is ethyl acetate and petroleum ether (v:v =1:6), the lysine derivative Fmoc-Lys(furoyl)-OH was obtained.
[0067] (2) Dissolve 0.07 g of glycol chitosan (GC) in 12 mL of DMSO, stir overnight, add dropwise a DMSO solution (1 mL) of 0.08 g of furoic acid and 0.25 g of BOP, and plac...
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