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Gel material for efficient treatment of tumors and preparation method thereof

A gel material and high-efficiency technology, applied in the field of medical nano-biomaterials, can solve the problems of body function of patients with toxic and side effects, physical and mental trauma of patients, failure to effectively suppress cancer mortality, etc., and achieve safe treatment and efficient responsive enzyme-catalyzed reaction. Effect

Inactive Publication Date: 2017-10-13
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current main treatment methods for tumors are traumatic surgery and chemotherapy. The current effects often not only fail to effectively suppress cancer mortality, but the toxic and side effects of long-term treatment will also cause a sharp decline in the patient's body function, resulting in iatrogenic, drug-sourced Diseases proliferate, and treatment itself creates new physical and psychological trauma and even disability for patients

Method used

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  • Gel material for efficient treatment of tumors and preparation method thereof
  • Gel material for efficient treatment of tumors and preparation method thereof
  • Gel material for efficient treatment of tumors and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A furan functionalized composite macroscopic hydrogel is prepared by the following method:

[0048] (1) Dissolve 0.5g of Fmoc-Lys-OH in 2mL THF and 1mL 1M NaHCO 3 In the mixed solvent, cool in an ice-water bath, then add 0.26g of furoyl chloride dropwise, react at room temperature overnight, add 10mL of dichloromethane, wash with dilute hydrochloric acid solution of pH = 2-3, distilled water and saturated saline, and then use anhydrous sulfuric acid Drying over sodium, spinning off dichloromethane to obtain a light yellow to colorless viscous liquid, drying under vacuum at room temperature overnight to obtain a light yellow fluffy flake solid, purified by column chromatography, the eluent is ethyl acetate and petroleum ether (v:v =1:6), the lysine derivative Fmoc-Lys(furoyl)-OH was obtained.

[0049] (2) Dissolve 0.05 g of glycol chitosan (GC) in 10 mL of DMSO, stir overnight, add dropwise 0.066 g of furoic acid and 0.21 g of BOP in DMSO (1 mL), and place the resulting...

Embodiment 2

[0059] A furan functionalized composite macroscopic hydrogel is prepared by the following method:

[0060] (1) Dissolve 0.3g of Fmoc-Lys-OH in 3mL THF and 0.8mL 1M NaHCO 3 In the mixed solvent, cool in an ice-water bath, then add 0.2 g of furoyl chloride dropwise, react overnight at room temperature, add 8 mL of dichloromethane, wash with dilute hydrochloric acid solution of pH = 2-3, distilled water and saturated saline, and then wash with anhydrous sulfuric acid Drying over sodium, spinning off dichloromethane to obtain a light yellow to colorless viscous liquid, drying under vacuum at room temperature overnight to obtain a light yellow fluffy flake solid, purified by column chromatography, the eluent is ethyl acetate and petroleum ether (v:v =1:6), the lysine derivative Fmoc-Lys(furoyl)-OH was obtained.

[0061] (2) Dissolve 0.03 g of glycol chitosan (GC) in 8 mL of DMSO, stir overnight, add dropwise 0.06 g of furoic acid and 0.15 g of BOP in DMSO (1 mL), and place the res...

Embodiment 3

[0065] A furan functionalized composite macroscopic hydrogel is prepared by the following method:

[0066] (1) Dissolve 0.8g of Fmoc-Lys-OH in 5mL THF and 1.2mL 1M NaHCO 3 In a mixed solvent, cool in an ice-water bath, then dropwise add 0.3g of furoyl chloride, react overnight at room temperature, add 12mL of dichloromethane, wash with dilute hydrochloric acid solution of pH = 2-3, distilled water and saturated saline, and then wash with anhydrous sulfuric acid Drying over sodium, spinning off dichloromethane to obtain a light yellow to colorless viscous liquid, drying under vacuum at room temperature overnight to obtain a light yellow fluffy flake solid, purified by column chromatography, the eluent is ethyl acetate and petroleum ether (v:v =1:6), the lysine derivative Fmoc-Lys(furoyl)-OH was obtained.

[0067] (2) Dissolve 0.07 g of glycol chitosan (GC) in 12 mL of DMSO, stir overnight, add dropwise a DMSO solution (1 mL) of 0.08 g of furoic acid and 0.25 g of BOP, and plac...

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Abstract

The invention relates to a gel material for efficient treatment of tumors and a preparation method thereof. The gel material is composed of a supramolecular-macromolecular macro composite hydrogel carrier and loaded bio-enzyme components. The supramolecular-macromolecular macro composite hydrogel carrier is formed by self-assembly and crosslinking polymerization of a gelling factor, wherein the gelling factor comprises an aromatic substituted polypeptide micromolecule and a furanized polysaccharide molecule. Compared with the prior art, the micro organic-inorganic hybrid nano-gel carrier adopted by the invention provides natural protection for loading and immobilization of bio-enzyme, glucose responsive and reactive oxygen species responsive efficient and tandem enzyme-catalyzed reaction is carried out at a tumor site, tumor lesion site or other lesion sites to generate singlet oxygen, thus realizing efficient and safe treatment.

Description

technical field [0001] The invention relates to the technical field of medical nano-biological materials, in particular to a gel material for efficient treatment of tumors and a preparation method thereof. Background technique [0002] In recent years, the incidence of malignant tumors in my country has been increasing year by year, seriously endangering human health. The current main treatment methods for tumors are traumatic surgery and chemotherapy. The current effects often not only fail to effectively suppress cancer mortality, but the toxic and side effects of long-term treatment will also cause a sharp decline in the patient's body function, resulting in iatrogenic, drug-sourced Diseases proliferate, and the treatment itself creates new physical and psychological trauma and even disability for patients. How to achieve a safer and more effective tumor treatment has become a major social issue, and it is also a difficult problem that researchers in materials, chemistry...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/18A61K47/36A61K47/42A61K41/00A61K49/22A61K9/00A61P35/00C08B37/08C07D307/46
Inventor 王启刚王霞吴青位青聪
Owner TONGJI UNIV
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