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Preparation method and application of high-bioavailability Pummelo Peel extract

A technology for denaturing tangerine red and citrus brown sugar, which is applied in the field of modified preparation of flavonoids, can solve the problems of limited biological production application, unfavorable industrial production, and high equipment production cost, achieve high medical and health care value, shorten production cycle, and widen Effects in the field of practical application

Inactive Publication Date: 2017-10-13
FOSHAN GOLDEN HEALTH TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The method for the glycosylation of the flavonoids in the existing orange red, such as the publication number CN102051397A, requires a high purity of the flavonoids in the rough orange red (the purity of the flavonoids in the orange red is more than 90%), and the conversion rate is relatively low (about 50-80%, lower than the conversion rate of 90% of the present invention), and there are flavonoids and residual glucose in the glycosylated orange red, greatly reducing its medicinal value; as publication number CN 104862362A, although the glycosylation purity of the flavonoids in Tangerine is high, it is required to produce the flavonoids in higher glycosylated Huatangerine under the condition of re-preparing the liquid phase, the equipment production cost is high, and the yield per unit time Low, complex production process, not conducive to industrial production, greatly limiting the application in biological production

Method used

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  • Preparation method and application of high-bioavailability Pummelo Peel extract
  • Preparation method and application of high-bioavailability Pummelo Peel extract
  • Preparation method and application of high-bioavailability Pummelo Peel extract

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Embodiment 1

[0034]A synthesis and purification method for preparing flavonoids in glycosylated orange, characterized in that the specific method steps are as follows:

[0035] (1) prepare the flavonoid compound solution in orange red

[0036] Dissolve the flavonoid compound in the commercially available mass concentration of 50% citrus red in sodium hydroxide or potassium hydroxide solution with a molar concentration of 0.1-1mol / L, and treat it at 30-40°C for 30 minutes to prepare citrus Solution of flavonoids in Tangerine.

[0037] (2) prepare the flavonoid compound ultrafiltration solution in Huajuhong

[0038] After the first step (1) is completed, the flavonoid solution in the orange red prepared by the first step (1) is first pumped into a polyethersulfone membrane ultrafilter with a molecular weight cut-off of 1000~2000Da, and the ultrafiltration pressure is controlled to be 0.1~2000Da. 0.3MPa, carry out ultrafiltration treatment until the volume of the ultrafiltration retentate i...

Embodiment 2

[0043] A synthesis and purification method for preparing flavonoids in glycosylated orange, characterized in that the specific method steps are as follows:

[0044] (1) prepare the flavonoid compound solution in orange red

[0045] Dissolve the flavonoids in the commercially available citrus red with a mass concentration of 60% in sodium hydroxide or potassium hydroxide solution with a molar concentration of 0.4 to 0.5 mol / L, and treat it at 35°C for 30 minutes to prepare citrus red solution of flavonoids in .

[0046] (2) prepare the flavonoid compound ultrafiltration solution in Huajuhong

[0047] After the first step (1) is completed, the flavonoid solution in the orange red prepared in the first step (1) is first pumped into a polyethersulfone membrane ultrafilter with a molecular weight cut-off of 1000~2000Da, and the ultrafiltration pressure is controlled to be 0.2~2000Da. 0.4MPa, carry out ultrafiltration treatment until the volume of the ultrafiltration retentate is ...

Embodiment 3

[0053] A synthesis and purification method for preparing flavonoids in glycosylated orange, characterized in that the specific method steps are as follows:

[0054] (1) prepare the flavonoid compound solution in orange red

[0055] Dissolve the flavonoids in commercially available citrus red with a mass concentration of 70% in sodium hydroxide or potassium hydroxide solution with a molar concentration of 0.6 to 1 mol / L, and treat at 30 to 40°C for 30 minutes to prepare citric acid Solution of flavonoids in Tangerine.

[0056] (2) prepare the flavonoid compound ultrafiltration solution in Huajuhong

[0057] After the first step (1) is completed, the flavonoid solution in the orange red prepared in the first step (1) is first pumped into a polyethersulfone membrane ultrafilter with a molecular weight cut-off of 1000~2000Da, and the ultrafiltration pressure is controlled to be 0.2~2000Da. 0.3MPa, carry out ultrafiltration treatment until the volume of the ultrafiltration retent...

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Abstract

The invention discloses a preparation method and an application of high-bioavailability Pummelo Peel extract. The method comprises the following operating steps: 1, preparing an extract solution from commercial Pummelo Peel extract; 2, carrying out glycosidase catalytic glycosylation on the extract; 3, carrying out membrane separation and concentration on the above obtained glycosylation product; and 4, drying and collecting high-bioavailability glycosylated Pummelo Peel extract. The application is the application of the high-bioavailability Pummelo Peel extract in the production of medicinal preparations, healthcare products or special formula foods. The high-bioavailability Pummelo Peel extract realizes the glycosylation of Pummelo Peel extract flavones through a biological enzyme conversion technology, so the solubility in water and the in-vitro dissolve-out speed of the Pummelo Peel extract are improved, and the bioavailability is improved.

Description

1. Technical field [0001] The invention belongs to the technical field of modification and preparation of flavonoid compounds, and relates to a production process for improving the bioavailability and efficacy of active ingredients of Huazhou Juhong. 2. Technical Background [0002] Huazhou Juhong, also known as "Huazhou Chenpi", is a Rutaceae plant. Its immature peel has the functions of reducing phlegm, regulating qi, invigorating the stomach, and digesting food. Wait. Studies have shown that the active ingredients in Huajuhong are flavonoids. Although Huajuhong is a valuable Chinese medicinal material, the solubility of the main medicinal ingredients in pure water is very low, and the bioavailability is very low, which greatly reduces Knowing the medicinal value of citrus red, improving the bioavailability and drug effect of citrus red active ingredient is the problem to be solved in the present invention, [0003] Flavonoids are mainly found in citrus fruits, which hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P19/60C12P19/18A23L33/10A61K31/7048A61K9/19A61K9/16A61P35/00A61P29/00A61P39/06A61P3/06
CPCA23L33/10A61K9/1635A61K9/19A61K31/7048C12P19/18C12P19/60
Inventor 周金林卢宇靖郭晓路黄宝华林丽薇李慧灵邓诚
Owner FOSHAN GOLDEN HEALTH TECH CO LTD
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