Compound lysozyme sterilizing oral disinfectant and preparation method thereof

A technology of lysozyme and oral care agent, which is applied in the field of oral care, can solve the problems of not being able to achieve the ideal cleaning effect, achieve the effect of slightly sweet taste, low preparation conditions, and enhance the oral immune system

Pending Publication Date: 2017-10-24
江苏开源康达医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Oral microorganisms mainly exist in dental plaque, oral mucosa, dental calculus, gingival pockets, saliva, and postoperative dental pulp. Among them, dental plaque has a unique "biofilm" structure, while dental pulp is in a relatively closed cavity Therefore, brushing your teeth in the morning and evening and simply rinsing your mouth during the day with an interval of up to 12 hours cannot achieve the ideal cleaning effect, and you must use oral care solutions with long-term antibacterial effects

Method used

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  • Compound lysozyme sterilizing oral disinfectant and preparation method thereof
  • Compound lysozyme sterilizing oral disinfectant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The raw materials are 6 parts of lysozyme; 6 parts of amidase; 4 parts of sodium dihydrogen phosphate, 3 parts of sodium chloride, 2 parts of citric acid, 1.3 parts of sodium citrate, 0.2 parts of glycerin, 0.9 parts of silicone defoamer, 1.7 parts Flavoring agent, 150 parts of water. The flavoring agent is sorbose; the water is distilled water.

[0031] Its preparation method is as follows:

[0032] 1. Prepare solution A with 4 parts of sodium dihydrogen phosphate, 3 parts of sodium chloride and 75 parts of water, prepare solution B with 2 parts of citric acid, 1.3 parts of sodium citrate and 75 parts of water, and adjust the pH value of solution A Adjust to 6.8, adjust the pH of solution B to 6.0, and sterilize solution A and solution B at 121 °C for 15 minutes.

[0033] 2. Add 6 parts of lysozyme to the sterilized solution A, mix thoroughly at 2-8°C for 30 minutes at a low speed of 30 rpm, then sterilize and filter to obtain solution C.

[0034] 3. Add 6 parts of ...

Embodiment 2

[0038] The raw materials are 9 parts of lysozyme; 9 parts of amidase; 5 parts of sodium dihydrogen phosphate, 5 parts of sodium chloride, 7 parts of citric acid, 2.5 parts of sodium citrate, 0.2 parts of glycerin, 1.1 parts of silicone defoamer, 2.4 parts Flavoring agent, 180 parts of water. The flavoring agent is sorbose; the water is distilled water.

[0039] Its preparation method is as follows:

[0040] 1. Prepare solution A with 5 parts of sodium dihydrogen phosphate, 5 parts of sodium chloride and 90 parts of water, prepare solution B with 7 parts of citric acid, 2.5 parts of sodium citrate and 90 parts of water, and adjust the pH value of solution A Adjust to 6.8, adjust the pH of solution B to 6.0, and sterilize solution A and solution B at 121 °C for 15 minutes.

[0041] 2. Add 9 parts of lysozyme to the sterilized solution A, mix thoroughly at 2-8°C for 30 minutes at a low speed of 30 rpm, and then sterilize and filter to obtain solution C.

[0042] 3. Add 9 parts...

Embodiment 3

[0046] The raw materials are 7 parts of lysozyme; 7 parts of amidase; 5 parts of sodium dihydrogen phosphate, 4 parts of sodium chloride, 5 parts of citric acid, 1.5 parts of sodium citrate, 0.2 parts of glycerin, 1.1 parts of silicone defoamer, 2.4 parts Flavoring agent, 150 parts of water. The flavoring agent is stevioside; the water is ionized water.

[0047] 1. Prepare solution A with 5 parts of sodium dihydrogen phosphate, 4 parts of sodium chloride and 75 parts of water, prepare solution B with 5 parts of citric acid, 1.5 parts of sodium citrate and 75 parts of water, and adjust the pH value of solution A Adjust to 6.8, adjust the pH of solution B to 5.8, and sterilize solution A and solution B at 121 °C for 15 minutes.

[0048] 2. Add 7 parts of lysozyme to the sterilized solution A, mix thoroughly at 2-8°C for 30 minutes at a low speed of 30 rpm, and then sterilize and filter to obtain solution C.

[0049] 3. Add 7 parts of amidase to the sterilized solution B, mix t...

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Abstract

The invention discloses a compound lysozyme oral care agent which comprises lysozyme, amidase, sodium dihydrogen phosphate, sodium chloride, citric acid, sodium citrate, glycerol, an organic silicon defoamer, a condiment and water. The invention also discloses a preparation method of the compound lysozyme oral care agent.

Description

technical field [0001] The invention belongs to the field of oral care, and more specifically, the invention relates to a compound lysozyme antibacterial oral care agent and a preparation method thereof. Background technique [0002] The oral cavity is the beginning part of the digestive canal and is also an important organ of the human face. With the continuous improvement of social living standards, oral health has increasingly become an important part of human health. In order to protect the normal function of the oral cavity, people generally perform daily oral care and cleaning by brushing their teeth in the morning and evening, and gargling with tea or boiled water after meals. If there is a health disorder in the oral system or after dental treatment such as extraction, filling, implant, scaling, orthodontics, deeper oral care is required. [0003] Oral microorganisms mainly exist in dental plaque, oral mucosa, dental calculus, gingival pockets, saliva, and postoper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/66A61Q11/00A61P1/02A61P31/02A61P31/04A61K38/54A61K38/47
CPCA61K8/66A61K38/47A61K38/50A61K38/54A61Q11/00C12Y302/01017C12Y305/01004A61K2300/00
Inventor 孙开源
Owner 江苏开源康达医疗器械有限公司
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