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Bacterial infection resistance pharmaceutical composition and application thereof

A composition and drug technology, applied in the direction of antibacterial drugs, pharmaceutical formulations, plant raw materials, etc., can solve the problem of drug efficacy reduction and achieve high drug efficacy, less bacterial resistance, no toxic side effects and drug dependence Effect

Active Publication Date: 2017-10-27
INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in just a few decades, the efficacy of most antibiotics has been reduced to varying degrees after application. The problem of bacterial resistance in my country is particularly prominent. The abuse of antibiotics has made the emergence of bacterial resistance much faster than imagined.

Method used

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  • Bacterial infection resistance pharmaceutical composition and application thereof
  • Bacterial infection resistance pharmaceutical composition and application thereof
  • Bacterial infection resistance pharmaceutical composition and application thereof

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Experimental program
Comparison scheme
Effect test

preparation example Construction

[0045] In addition, in order to facilitate the pharmaceutical composition of the present invention to make various medicaments more conveniently, the preparation method of the present invention also includes:

[0046] At 50-60°C, the filtrate obtained after ethanol extraction was concentrated into a thick paste.

[0047] Wherein, the relative density of the thick paste is preferably 1.10-1.15.

[0048] Taking the pharmaceutical composition of the present invention and broad-spectrum β-lactam antibiotics amoxicillin, quinolones antibacterial drug levofloxacin hydrochloride in vitro antibacterial experiments show that the pharmaceutical composition of the present invention has a certain effect on common clinical infectious bacteria. certain inhibitory effect, and its inhibitory effect on Pseudomonas aeruginosa is extremely strong, which is better than the existing common anti-infective drugs; in the comparative test of infected mice, the pharmaceutical composition of the present...

Embodiment 1

[0053] Embodiment 1: prepare the capsule of pharmaceutical composition of the present invention

[0054] Take each crude drug (unit: g) by the following weight: marine organisms extract 20, Chinese medicine composition extract 90;

[0055] Take marine organisms (the ratio is 1 part of sea dragon, 8 parts of kelp), and the composition of traditional Chinese medicine (the ratio is 6 parts of Sophora flavescens, 5 parts of honeysuckle, 4 parts of Folium Folium, 3 parts of Cortex Phellodendri, and 5 parts of clove), and add 8 times the amount of the to-be-extracted The 70% ethanol reflux extraction of gross weight is 2 times, each 60min, filters, and the filtrate is concentrated under reduced pressure below 55 ℃ to the thick paste that relative density is 1.10-1.15, and spray drying obtains bulk drug (marine biological extract and traditional Chinese medicine composition extract). Weigh the crude drug according to the above weight, add sodium starch glycolate, fully mix, make gra...

Embodiment 2

[0056] Embodiment 2: prepare the tablet of pharmaceutical composition of the present invention

[0057] Take each crude drug (unit: g) by the following weight: marine organisms extract 20, Chinese medicine composition extract 60;

[0058] Take marine organisms (the ratio is 1 part of sea dragon, 7 parts of kelp), and the traditional Chinese medicine composition (the ratio is 5 parts of Sophora flavescens, 3 parts of honeysuckle, 7 parts of Folium chinensis, 2 parts of Cortex Phellodendri, and 8 parts of clove), and add 6 times the amount of the extract to be extracted The total weight of 90% ethanol was refluxed and extracted three times, each time for 60 minutes, filtered, the filtrate was concentrated under reduced pressure below 50°C to a thick paste with a relative density of 1.10-1.15, and spray-dried to obtain the crude drug. Take the bulk drug by the above weight, add sodium starch glycolate, fully mix, and send it into a tablet machine to form tablets.

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Abstract

The invention relates to the field of medicines and discloses a bacterial infection resistance pharmaceutical composition and application thereof. The pharmaceutical composition comprises marine organisms and a traditional Chinese medicine composition. The efficient and safe pharmaceutical composition prepared from seven natural medicines has an effect of resisting various types of bacterial infection, can be used for eliminating in-vivo pathogenic bacteria effectively, does not cause drug resistance easily, has no toxic or side effect and no drug dependence for human bodies and is superior to the conventional drug preparation product; therefore, the pharmaceutical composition can be widely applied to preparation of a bacterial infection resistance drug.

Description

technical field [0001] The invention relates to the field of medicines, in particular to an antibacterial infection pharmaceutical composition and its application. Background technique [0002] Bacterial infection has always been a medical problem that puzzles mankind. Since penicillin began to be used clinically, a variety of antibiotics have been discovered one after another. Some people once believed that the era of human beings defeating bacteria has arrived. However, in just a few decades, the efficacy of most antibiotics has been reduced to varying degrees after application. The problem of bacterial resistance in my country is particularly prominent. The abuse of antibiotics has made the emergence of bacterial resistance much faster than imagined. . Bacterial quorum sensing (QS) is considered to be an ideal target for the development of new antibacterial drugs. It refers to a group behavior in which bacteria use their own signal molecules to monitor changes in their o...

Claims

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Application Information

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IPC IPC(8): A61K36/855A61K36/756A61P31/04A61K35/60
CPCA61K35/60A61K36/03A61K36/195A61K36/315A61K36/355A61K36/489A61K36/61A61K36/704A61K36/756A61K36/855A61K2236/333A61K2236/39A61K2300/00Y02A50/30
Inventor 赵友兴马青云周丽曼孔凡栋谢晴宜戴好富
Owner INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI
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