Plastic artificial bone and preparation method thereof

Abstract

The invention discloses a plastic artificial bone which contains, by weight, 50%-90% of porous calcium phosphate ceramic and 50%-10% of soluble collagen. The soluble collagen forms a three-dimensional collagen fiber net structure in gaps of the porous calcium phosphate ceramic. A preparation method of the plastic artificial bone comprises the steps that the porous calcium phosphate ceramic is firstly and ultrasonically rinsed, and then collagen pretreatment A and collagen pretreatment B are performed; then, the porous calcium phosphate ceramic is put in pretreatment collagen A and pretreatment collagen B for infiltration and coating, freeze-drying and crosslinking are performed to obtain the plastic artificial bone. The adverse influence of matrix metalloproteinase (MMP-2 and MMP-9) and Stromelysins and Matrilysin on wounds is weakened through the collagen pretreatment A, and the mechanical strength of the plastic artificial bone is enhanced through the collagen pretreatment B. The plastic artificial bone has a uniform three-dimensional structure through coating and then freeze-drying and crosslinking, and the repair of the bone tissues can be better guided and accelerated.

Description

technical field [0001] The invention relates to a composite biological material, in particular to a plastic artificial bone and a preparation method thereof. Background technique [0002] Hard tissue (bone, tooth) substitute materials are a large category of biomaterials. In the biomaterial industry, about 20% of the materials involved in hard tissue repair and replacement. For a populous country like China, the huge potential demand is obvious. In addition, my country is stepping into an elderly society, and the elderly population over 60 years old has reached 140 million. Old age-induced body tissues, especially hard tissue lesions, such as osteoporosis, require a large amount of bone substitute materials for clinical treatment . Therefore, research in this field has far-reaching social impact and huge economic benefits. [0003] At present, there are two main types of scaffold materials for bone tissue engineering; one is biologically derived materials, which are proces...

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the fact that the size of the existing HAP and β-TCP bioceramic materials in clinical application cannot fully match the expected size, thereby prolonging the operation time and causing secondary damage to the patient's wound, and the affected part and the Some gaps remaining between the implant materials will further hinder the bone healing and thus provide a plastic artificial bone and its preparation method