Antibacterial crosslinked nanoparticles and preparation method thereof

A nanoparticle and antibacterial technology, applied in the field of antibacterial cross-linked emulsion and its preparation, can solve the problems of many additives and uneven particle size distribution of the product, and achieve the effects of simple operation, less harsh preparation conditions and good antibacterial effect.

Active Publication Date: 2017-11-07
SUZHOU UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the existing polymer preparation process has problems such as too many additives and uneven particle size distribution of the product.

Method used

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  • Antibacterial crosslinked nanoparticles and preparation method thereof
  • Antibacterial crosslinked nanoparticles and preparation method thereof
  • Antibacterial crosslinked nanoparticles and preparation method thereof

Examples

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Embodiment 1

[0026] Synthesis of water-soluble homopolymer PDMAEMA as a macromolecular chain transfer agent

[0027] The homopolymer PDMAEMA was prepared by solution polymerization using tetrahydrofuran (THF) as solvent. In molar ratio [DMAEMA] 0 / [CPDN] 0 / [AIBN] 0 = 60 / 3 / 0.5 as an example, chain transfer agent CPDN (325.5 mg, 1.20 mmol), initiator AIBN (65.5 mg, 0.40 mmol), monomer DMAEMA (4.0 mL, 23.7 mmol) and THF (1.4 mL) were added into an ampoule equipped with a magnetic stirring bar, after three freezing-pumping-thawing deoxygenation operations, the ampoule bottle mouth was flame-melted and sealed, and placed in an oil bath with a pre-set temperature (70°C) for reaction. After the polymerization reaction reached a certain period of time, the ampoule was taken out and immersed in an ice-water bath to cool down to quench the reaction. Scratch the mouth of the bottle, take a small amount of reaction solution and dissolve it in D 2 O, NMR characterization was performed to determ...

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Abstract

The invention relates to antibacterial crosslinked nanoparticles and a preparation method thereof. The method comprises the steps of firstly, adopting solution polymerization to synthesize poly [2-(N,N-dimethyl amino)ethyl methacrylate] (PDMAEMA) under the regulation of a reversible addition fragmentation chain transfer (RAFT) agent-CPND; then, under the acidic condition, taking the PDMAEMA as a macromolecule RAFT agent, and adding oil-soluble monomer methyl methacrylate (MMA) and a crosslinking agent-ethylene glycol dimethacrylate (EGDMA) in a semi-continuous charging way to prepare crosslinked nano emulsion for soap-free antibacterial particles. After that, the nanoparticles are enabled to be subjected to quaternization, and the good antibacterial property of the nanoparticles is verified by taking gram-negative bacteria escherichia coli as an experimental strain and using a spread-plate method.

Description

technical field [0001] The invention belongs to antibacterial material technology, and in particular relates to an antibacterial cross-linked emulsion and a preparation method thereof. Background technique [0002] Bacteria are ubiquitous in life. Infections and diseases caused by bacteria have claimed too many lives in the course of human history, so scientists have not stopped researching on antibacterial substances. People's research on antibacterial agents began with small molecule antibacterial agents, and in recent years has mainly focused on the research of polymer antibacterial agents. Polymer antibacterial agents have unique advantages in terms of chemical stability, long-lasting action, and low toxicity. At present, the research on polymer antibacterial agents mainly has two aspects: introducing antibacterial substances on the surface of the sheet and preparing antibacterial nanoparticles. Du's group prepared polyethylene oxide, polyε-caprolactone, polyethylamino...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F8/44C08F265/04C08F120/34C08F220/14C08F220/20A01N33/12A01P1/00
CPCA01N33/12C08F8/44C08F120/34C08F265/04C08F220/14C08F220/20
Inventor 程振平武娟娟张丽芬于谦朱秀林
Owner SUZHOU UNIV
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