31 results about "Nitroso Compounds" patented technology

The invention belongs to the technical field of medicine detection, and particularly relates to a method for detecting a nitroso compound in a raw material medicine in a riptacaine emulsifiable paste, which comprises the following steps: preparing a test sample: taking the riptacaine emulsifiable paste, adding a 5mol / L sodium hydroxide solution, uniformly mixing, then adding a 5mol / L hydrochloric acid solution, and uniformly mixing; diluting with a solvent with the pH value of 7.20 + / -0.02, and then centrifugally filtering to obtain a test sample; wherein the solvent is a mixed solvent composed of monopotassium phosphate and acetonitrile; liquid chromatography separation: the tested sample is separated by liquid chromatography, and a mobile phase A is a 0.2% formic acid solution; the mobile phase B is methanol; the chromatographic column is SB-C18, 2.1 * 100 mm, 1.7 [mu] m; and mass spectrum detection: detecting the substance separated by the liquid chromatography by using a mass spectrometer to obtain the content of the nitroso compound. The detection method is efficient, sensitive and excellent in reproducibility.

The invention discloses an ultrahigh-performance offshore wind power grouting material as well as a preparation method and application thereof. The ultrahigh-performance offshore wind power grouting material is prepared from the following components in parts by weight: 600 to 800 parts of cement, 100 to 200 parts of a viscosity reducer, 75 to 150 parts of silica fume, 75 to 150 parts of ground zeolite powder, 6 to 8 parts of a water reducing agent, 1 to 2 parts of a de-foaming agent, 0.1 to 0.5 part of a plastic expanding agent, 50 to 80 parts of an anti-cracking agent, 700 to 900 parts of carborundum and 155 to 170 parts of water, the cement is 52.5-grade white portland cement; the viscosity reducer is prepared from the following components in percentage by weight: 30 percent to 50 percent of microbeads, 15 percent to 35 percent of limestone powder, 20 percent to 30 percent of superfine mineral powder and 5 percent to 15 percent of metakaolin, and the viscosity reducer is prepared from the following components in percentage by weight: 30 percent to 50 percent of microbeads, 15 percent to 35 percent of limestone powder, 20 percent to 30 percent of superfine mineral powder and 5 percent to 15 percent of metakaolin. The plastic expanding agent is composed of an azo compound plastic expanding agent and a nitroso compound plastic expanding agent in a weight ratio of (0.5-2): 1. The ultrahigh-performance offshore wind power grouting material is high in early strength, good in fluidity and excellent in durability, has the micro-expansion characteristic, and is simple in preparation process and low in cost.

The invention discloses a method for detecting an N-nitroso compound in vortioxetine hydrobromide, and the N-nitroso compound is 2, 2 '-(nitroso amino) bis-acetonitrile. According to the method, a high performance liquid chromatography is adopted, an octadecyl silane bonded silica gel filler chromatographic column and an ultraviolet detector are adopted, a mobile phase A is 0.05% phosphoric acid aqueous solution, a mobile phase B is methanol, and gradient elution is adopted. The method has good specificity and sensitivity.

This invention relates to the field of organic synthesis technology, specifically to a method for preparing aryltriazene; comprising the following steps: (1) preparing an aromatic nitroso compound Ar 1 NO is dissolved in the first solvent in the first ratio to obtain solution A; (2) unsymmetrical disubstituted hydrazine R 1 R 2 NNH2 is dissolved in the second solvent in the second ratio to obtain solution B; (3) under stirring, solution A and solution B are mixed and subjected to dehydration condensation reaction for 1-4 hours, and the reaction temperature of dehydration condensation is 10-40℃; after the reaction is completed, aromatic triazine is obtained by separation and purification; the first solvent and the second solvent are aprotic solvents; Ar 1 It is any of the substituted or unsubstituted phenyl, heterocyclic aryl, and fused-ring aryl groups, and the substituents on the ring do not react with hydrazine; R 1 R 2 It is at least one of alkyl and aryl groups. This preparation method is simple to synthesize, produces no unstable diazonium salt intermediates, has mild reaction conditions, and a relatively fast reaction rate.

The invention relates to the technical field of flocking adhesives, in particular to a high-performance single-component flocking adhesive and a preparation method thereof.The high-performance single-component flocking adhesive is at least prepared from, by mass, 40-60% of blocked polyurethane, 5-15% of phenol novolac epoxy resin, 0-5% of aromatic nitroso compounds, 0-5% of imine compounds and the balance solvent, the closed polyurethane has an oxime carbamate structure, the weight-average molecular weight is 60000-90000, by optimizing a product formula system, the problems of poor wear resistance, poor solvent resistance and the like after an adhesive is coated are effectively solved, meanwhile, the operation is convenient and fast, the efficiency is high, the application scene and the application range of the adhesive are expanded, and the market demand is better met.

The present invention provides an electrochemical pre-activation detection method for identifying isomers of aromatic nitro compounds, belonging to the field of electrochemical detection. Specifically, when performing differential pulse voltammetry (DPV) electrochemical detection on isomers of aromatic nitro compounds, the isomers of aromatic nitro compounds are first electrochemically pre-activated. Electrochemical pre-activation means applying a negative potential first, and the isomers of aromatic nitro compounds are reduced to isomers of aromatic nitroso compounds. The isomers of aromatic nitroso compounds further undergo redox reactions to generate isomers of aromatic hydroxylamine compounds. When using DPV electrochemical detection for redox reactions, the peak positions of the isomers are spaced relatively far apart, thereby achieving effective identification and detection of isomers of aromatic nitro compounds.

The present invention discloses a method for synthesizing an asymmetric azoxybenzene compound. Under light irradiation conditions, iminoiodobenzene and a nitroso compound are reacted in dichloromethane. First, iminoiodobenzene generates nitrene under light irradiation conditions, and then it is captured by the nitroso compound to generate an asymmetric azoxybenzene compound. This method is driven by visible light as a green energy source, without the addition of a catalyst, and the target product can be obtained by reacting for 2 h at room temperature. The reaction conditions are mild and rapid, and at the same time, it is insensitive to air and water and is easy to operate.

To provide a method for reducing the generation of nitroso compounds in a drug raw material or a drug.SOLUTION: This method includes the following step A and / or B. Step A: a step for removing at least a portion of nitrogen oxides in an atmosphere that comes into contact with the drug raw material or the drug. Step B: a step for producing and / or storing the drug raw material or the drug under an atmosphere where the content of the nitrogen oxides is 50 ppb or less.SELECTED DRAWING: Figure 3

This application provides a quantitative method for the derivatization of nitrogen nitrosamines and its application. Through simple derivatization, nitrogen nitrosamines with different structures can be determined. In the embodiments of this application, the sample derivatization method is studied, and optimal reaction conditions for nitrogen nitrosamines are proposed. This application establishes a simple and sensitive liquid chromatography quantitative analysis method, successfully establishing a method for the derivatization analysis of nitrogen nitrosamines with different structures. This method has high selectivity, sensitivity, and accuracy, and is suitable for the accurate determination of nitrogen nitrosamines in complex samples and complex structures.

A photosensitive resin composition comprising (A) an alkali-soluble polymer, (B) a compound having an ethylenically unsaturated bond, (C) a photoinitiator, (D) a sensitizer, and (E) polymerization inhibitors, wherein (C) the photoinitiator includes one or more selected from a 2,4,5-triallyl imidazole dimer and an acridine compound, the contained amount of (C) the photoinitiator is 5.0 mass% or more with respect to the total mass of solid content of the photosensitive resin composition, (D) the sensitizer contains a specific compound represented by the compound described by formula (D1-1), and (E) the polymerization inhibitors include (E1) a first polymerization inhibitor selected from nitroso compounds and nitroxyl radicals and (E2) a second polymerization inhibitor other than the first polymerization inhibitor.

Disclosed herein are materials, articles of manufacture, and methods for reducing, mitigating, or precluding formation of and / or amount of a nitrosating agent and / or an N-nitroso compound, including an N-nitrosamine, from a packaging containing an active agent and a pharmaceutical dosage form in an enclosure, wherein the active agent is effective to reduce mitigate or preclude the formation and / or amount of a nitrosating agent and / or N-nitroso compound in the enclosure and / or in the pharmaceutical dosage form. Provided are drug delivery systems comprising a blister pack configured to house multiple pharmaceutical dosage forms, the blister pack comprising an active ingredient that is effective to reduce, mitigate or preclude the formation and / or amount of a nitrosating agent and / or N-nitroso compound in an enclosure of the blister pack and / or in the pharmaceutical dosage form.

One embodiment according to this invention provides a method for selecting an additive agent for suppressing a nitrosation reaction. Alternatively, one embodiment of the present invention provides a formulation that suppresses the generation of nitroso compounds, including an additive agent selected by a method for selecting an additive agent for suppressing a nitrosation reaction. In one embodiment, a method for selecting an additive agent for suppressing a nitrosation reaction includes adding an amine source and an NOx source to an additive agent to generate nitroso compounds, quantifying an amount of the generated nitroso compounds, and evaluating a suppressing effect of the nitrosation reaction of the additive agent based on the amount of the generated nitroso compounds.

Disclosed herein are materials, articles, and methods for reducing, mitigating, or excluding the formation and / or amount of nitrosylating agents and / or N-nitroso compounds, including N-nitrosamines, in a package containing an active agent and a pharmaceutical dosage form in a shell, wherein the active agent can be effective to reduce, mitigate, or exclude the formation and / or amount of nitrosylating agents and / or N-nitroso compounds in the shell and / or in the pharmaceutical dosage form. There is provided a drug delivery system comprising a blister pack configured to contain a plurality of drug dosage forms, the blister pack comprising an active ingredient, the active ingredient may be effective to reduce, mitigate, or exclude the formation and / or amount of nitrosylating agents and / or N-nitroso compounds in the outer shell of the blister pack and / or in the pharmaceutical dosage form.

The invention belongs to the field of metal bonding, and particularly relates to an adhesive composition for bonding baking-resistant rubber and metal and a preparation method of the adhesive composition. The adhesive composition is prepared from the following raw materials: modified halogen sulforubber, a nitroso compound cross-linking agent, an acid-binding agent, an adhesion accelerant and a dispersing agent, the preparation method comprises the following steps: firstly grinding and mixing the nitroso compound cross-linking agent, the accelerant, the dispersing agent and the like to prepare mother liquor, and then mixing with the modified halogen sulforubber and the like. The adhesive composition still keeps activity at 160-200 DEG C, is suitable for various elastomers, and is resistant to high-temperature fluid, resistant to corrosion and high in process adaptability.

The application discloses an organic boron reagent alpha-boryl oxime compound and a preparation method and application thereof, and belongs to the technical field of organic synthesis. N The alpha-boryl oxime compound is prepared by reacting a heterocyclic carbene borane adduct and a nitroso compound in an organic solvent. N The alpha-boryl oxime compound is prepared by simultaneously introducing an oxime group and a boron group functional group into both ends of the olefin with high selectivity through the boro-oximation reaction of the heterocyclic carbene borane, the nitrosamine compound and the olefin. The reaction avoids the use of a photosensitizer and a transition metal, has very good functional group tolerance and substrate universality, and also has good chemical selectivity, regioselectivity and stereoselectivity; the product alpha-boryl oxime compound can be efficiently used to synthesize various useful compounds through simple conversion, the types of the organic boron reagent are expanded, and the application prospect is good.

This application relates to the field of lithium-ion battery solid electrolyte material preparation technology, and particularly to a LATP solid electrolyte material with high stability to lithium metal anode and its preparation method. The material includes an LATP matrix; an organic coating layer covering the surface of the LATP matrix, wherein the organic coating layer is a bonding layer formed by grafting an organic coating layer with oxidizing functional groups onto a coupling agent, the thickness of which is 3-50 nm, accounting for 0.3%-5% of the total mass of the LATP solid electrolyte material. The organic compounds with oxidizing functional groups are selected from nitro compounds, nitroso compounds, or N-oxides. These functional groups inhibit the reduction of titanium ions in LATP through reversible redox reactions, significantly improving the interfacial stability between LATP and the lithium metal anode. The material preparation method of this application is simple, low-cost, and can effectively extend the cycle life of lithium metal batteries.

The present invention provides a pharmaceutical product containing sitagliptin or a salt thereof, wherein the generation of nitroso compounds derived from sitagliptin or a salt thereof is reduced. [Solution] A pharmaceutical according to one aspect of the present invention is a pharmaceutical containing sitagliptin or a salt thereof. This pharmaceutical has a water content of 2.8% by weight or less as measured by the Karl Fischer method, and a content of nitroso compounds derived from sitagliptin or a salt thereof of 1.0 ppm or less.

The invention relates to the field of effective and economical conversion of nitro or nitroso compounds in to corresponding amines. More it discloses a reduction processes of nitro or nitroso compounds to corresponding amino compounds, which exhibit differential solubility, exemplified & not restricted to the processes discussed for m-aminoacetophenone, the intermediate of Phenylephrine, ethyl3- [[4-(methylamino)-3-aminobenzoyl](pyridin2yl)amino]propanoate the intermediate of Dabigatran, and 2,4-Difluoroaniline the intermediate of Pantoprazole. Even more particularly, the invention relates to a process involving use of minimal quantity of water or quantity of water required only as the source of hydrogen for generation of sufficient reduction potential to perform the chemical reaction. The process offers a. safer, cost competitive and greener alternative to the conventional process of reduction. A key benefit of the invention is that it avoids side product / s & / or impurity / s resulting from usage of large quantity of water especially when other sensitive / reactive groups are present in the molecule.

The invention relates to the technical field of photovoltaic cells, in particular to a preparation method of a surface-strengthened silicon wafer substrate of a photovoltaic cell, which comprises the following steps of: texturing the silicon wafer substrate, and performing surface strengthening treatment twice to obtain the surface-strengthened silicon wafer substrate; the two times of surface strengthening treatment are specifically as follows: during the first time of surface strengthening treatment, an etching solution A is adopted to smooth the surface appearance defects of the silicon wafer substrate, and during the second time of surface strengthening treatment, an etching solution B is adopted to smooth the surface lattice defects of the silicon wafer substrate, the acidic etching solution as the etching solution B comprises hydrofluoric acid, an oxidizing agent and deionized water, and the oxidizing agent is one or a combination of more of a nitro compound and a nitroso compound. The method has the beneficial effects that through two times of surface strengthening treatment, the bending breaking strength of the silicon wafer substrate is improved, and the bending breaking strength of the crystalline silicon photovoltaic cell is finally improved; the method can be completed without special equipment, and has the advantages of being low in production cost and suitable for large-scale production.

The application relates to the technical field of secondary batteries, and particularly discloses an additive for a positive electrode electrolyte, an electrolyte containing the same and application. The positive electrode electrolyte contains an electrolyte lithium salt, an organic solvent and an additive, the organic solvent is a carbonate solvent, and the additive is a nitrite or a nitroso compound. The electrolyte can be applied to a lithium ion battery or a lithium metal battery, and the electrolyte of the application can react on the surface of the positive electrode to generate an inorganic fast-ion solid-state electrolyte protection film rich in lithium nitrogen oxides, accelerate the transmission of lithium ions in the solid-state electrolyte film, and further improve the rate performance and cycle stability of the lithium ion battery.

To provide an active energy ray-curable peelable adhesive composition which enables production of an adhesive that has good adhesive force before irradiation with active energy rays, suppresses excessive reduction in adhesive force even when being exposed to high temperature, exhibits reduced adhesive force after irradiation with active energy rays, leaves no adhesive residue and has excellent peelability.SOLUTION: An active energy ray-curable peelable adhesive composition contains an acrylic resin (A), an urethane (meth)acrylate-based compound (B) and a polymerization inhibitor (C), wherein the polymerization inhibitor (C) contains a nitroso compound (C1).SELECTED DRAWING: None

The application discloses an ultra-high performance offshore wind power grouting material and a preparation method and application thereof. According to weight parts, the ultra-high performance offshore wind power grouting material comprises the following components: cement 600-800 parts, viscosity reducer 100-200 parts, silica fume 75-150 parts, ground zeolite powder 75-150 parts, water reducing agent 6-8 parts, defoaming agent 1-2 parts, plastic expansion agent 0.1-0.5 parts, anti-cracking agent 50-80 parts, carborundum 700-900 parts and water 155-170 parts; the cement is 52.5-grade white portland cement; the viscosity reducer is composed of microbeads, limestone powder, ultra-fine mineral powder and metakaolin, wherein the microbeads account for 30wt%-50wt%, the limestone powder accounts for 15wt%-35wt%, the ultra-fine mineral powder accounts for 20wt%-30wt% and the metakaolin accounts for 5wt%-15wt%; the plastic expansion agent is composed of an azo compound plastic expansion agent and a nitroso compound plastic expansion agent with a weight ratio of (0.5-2):1. The ultra-high performance offshore wind power grouting material has high early strength, good fluidity, excellent durability and micro-expansion characteristics, and has the advantages of simple preparation process and low cost.

A polynitroso compound, the polynitroso compound comprising a monocyclic core or a polycyclic core to which two or more terminal nitroso groups are attached, such as formula (A) to formula (D), especially formula (VII). A method for preparing the polynitroso compound of the present invention. An energy storage device, the energy storage device having a cathode comprising the polynitroso compound of the present invention. There is also provided an electrode material for an energy storage device, the electrode material comprising a polynitroso compound having a monocyclic core containing at least one terminal nitroso group, such as formula (A) to formula (D), especially formula (VII).

Provided is an active energy ray-curable peelable adhesive composition which has good adhesive force before irradiation with active energy rays, has reduced adhesive force after irradiation with active energy rays even when exposed to high temperatures, does not have adhesive residues, and has excellent peelability. An active energy ray-curable peelable adhesive composition containing an acrylic resin (A) and a nitroso compound (B), the content of the nitroso compound (B) being 0.01-1 parts by mass per 100 parts by mass of the acrylic resin (A).

The invention relates to an anti-wear high-activity metal rubber heat vulcanization adhesive and a preparation method thereof, and relates to the technical field of adhesive preparation, and the adhesive comprises film-forming resin, a nitroso compound, a special high-activity vulcanizing agent, a special reactive coupling agent, a reinforcing filler, an acid acceptor and a solvent. The anti-wear high-activity metal rubber heat vulcanization adhesive provided by the invention has excellent bonding strength on various rubber products which are difficult to bond, such as natural rubber products containing reclaimed rubber, low-compression permanent deformation rubber products, high-hardness rubber products, low-hardness rubber products, rubber products with high oil filling content and the like.

Provided is a method for reducing the generation of nitroso compounds in a drug raw material or a drug. This method includes the following step A and / or B. Step A: a step for removing at least a portion of nitrogen oxides in an atmosphere that comes into contact with the drug raw material or the drug. Step B: a step for producing and / or storing the drug raw material or the drug under an atmosphere where the content of the nitrogen oxides is 50 ppb or less.

The application relates to the technical field of photovoltaic cells, in particular to a preparation method of a surface-strengthened silicon wafer substrate of a photovoltaic cell. After texturing of a silicon wafer substrate, twice surface-strengthening treatment is carried out to obtain a surface-strengthened silicon wafer substrate. The twice surface-strengthening treatment specifically comprises: in the first surface-strengthening treatment, etching solution A is used to round and smooth the surface morphology defects of the silicon wafer substrate; and in the second surface-strengthening treatment, etching solution B is used to smooth the surface lattice defects of the silicon wafer substrate. The acidic etching solution B comprises hydrofluoric acid, an oxidizing agent and deionized water, and the oxidizing agent is a combination of one or several of nitro compounds and nitroso compounds. The beneficial effect is that the twice surface-strengthening treatment improves the bending fracture strength of the silicon wafer substrate and finally improves the bending fracture strength of the crystalline silicon photovoltaic cell; the method can be completed without using special equipment, has the advantages of low production cost and suitability for large-scale production.

This method for producing a nitroso compound of formula (3) involves reacting a compound of formula (1) with a compound of formula (2) in a dichloromethane solvent or an ether solvent in the presence of a tertiary alcohol and an alkali metal hydride.

An embodiment of the present invention provides a method for quantifying reactive NOx which is a source of NOx that may be involved in the generation of nitroso compounds. Alternatively, an embodiment of the present invention provides a formulation that suppresses the generation of a nitroso compound, designed based on a method for quantifying reactive NOx that may be involved in the generation of the nitroso compounds. In one embodiment, a method for quantifying reactive NOx includes adding an amine source to a sample to generate a nitroso compound. In one embodiment, nitroso compounds may be generated by heating under a sealed condition.

The application provides a construction method and application of a mouse spontaneous tumor model of gastric cancer, and the construction method comprises the following steps: reducing or inhibiting the expression amount of a TP53 gene and / or the activity of a P53 protein in a mouse, and then chemically inducing the mouse by using a drug to obtain a mouse spontaneous tumor model of gastric cancer; wherein the drug comprises sodium nitrite and ethyl sarcosine, and / or the drug comprises an N-nitroso compound. The application first proposes to use NESS to construct a spontaneous gastric cancer model of a C57 mouse, and the construction method of the mouse spontaneous tumor model of gastric cancer provided by the application has a tumor formation rate of 75% or more; the tumor formation cycle is short, about 3-4 months, and the construction cost is low.