40 results about "Diels alder" patented technology

The present invention relates to a Diels Alder polyol (DA polyol), a polymer composition comprising the DA polyol, and use of the polymer composition comprising the DA polyol as a coating, adhesive, sealant, elastomer or composite. More specifically, Diels Alder polyol comprising: a) a Diels-Alder unit, wherein the Diels-Alder unit is capable of a DA / rDA reaction, and, b) a dimer fatty residue, wherein the DA polyol necessarily contains at least two functional groups selected from hydroxyl groups, amino groups and / or carboxyl groups.

The application discloses application of a divinyl tetrazine in cyclization of a linear polypeptide, and a structure formula of the divinyl tetrazine is; the linear polypeptide has at least two free mercapto groups, and the vinyl groups of the divinyl tetrazine are subjected to Michael addition reaction with corresponding mercapto groups to form a ring. The application provides a new use of the divinyl tetrazine, the divinyl tetrazine can be subjected to high-efficiency Michael addition reaction with two natural cysteine mercapto groups on the linear polypeptide through the vinyl groups, so that double-mercapto peg cyclization of the linear polypeptide is realized, and the purpose of limiting the conformation of the linear polypeptide and improving the stability of the linear polypeptide is achieved. Moreover, the divinyl tetrazine can be subjected to a reverse electron demand Diels-Alder reaction with trans-cyclooctene (TCO) after the two vinyl groups are subjected to reaction with mercapto groups, so that functional polypeptides can be modularly constructed by coupling with functional molecules modified with TCO, and related applications are realized.

The application discloses a capped polyether containing a bridged ring structure and application thereof. The capped polyether is a surfactant containing a bridged ring structure, which is prepared by the following steps: 1-methyl-4-(1-methylethyl)-1,3-hexadiene and cis-butenediol are subjected to a Diels-Alder reaction to generate a diol intermediate A containing a bridged ring structure, then the diol intermediate A is subjected to polymerization reactions with propylene oxide and ethylene oxide under high pressure conditions to generate a gemini type polyether containing a bridged ring structure, and finally the obtained polyether is subjected to a reaction with acetic anhydride. The capped polyether containing a bridged ring structure prepared by the application has a good dispersing effect on photoresist, the gemini type structure features a lower CMC concentration, and thus the capped polyether has a better application in a developing solution.

A process for manufacturing recyclable fibrous architectures, comprising the following steps: a) supplying an aqueous solution in which at least one water-soluble polymer is dissolved, b) functionalizing the water-soluble polymer by reacting a first diene-type reagent and / or a second dienophile-type reagent, the first and second reagents forming a cycloaddition pair capable of carrying out a reversible cycloaddition reaction, in particular a reversible Diels-Alder cycloaddition reaction, c) respective addition of the second and / or first reagents of the reagent pair to obtain a precursor formulation of the adhesive formulation, d) coating polymer fibers with the precursor formulation.e) application of a heat treatment to crosslink the precursor formulation to obtain an adhesive formulation capable of reversibly assembling the polymer fibers into a recyclable fibrous architecture. Figure 4,

The invention relates to the technical field of polymer functional materials, and discloses a novel base plate and a processing technology thereof.The base material of the base plate is composed of furan functionalized polyurethane and bismaleimide which are cross-linked through a reversible Diels-Alder reaction, and a formed dynamic covalent network enables the base plate to have the thermally-induced self-repairing capacity; latent temperature-sensitive dye and latent photoluminescence molecules are uniformly dispersed in the matrix at the same time. The processing technology comprises the steps that the components are subjected to melt blending and compression molding to form a base plate biscuit, then ultraviolet light with the specific wavelength is used for selectively irradiating a preset area of the biscuit, and functional writing is completed. In the illumination step, latent functional molecules are activated in situ in the material, so that irreversible chemical structure transformation occurs on the latent functional molecules, and therefore, the high-wear-resistance embedded identifier with temperature-sensitive warning and light-induced verification functions is formed. The technical problems that a traditional base plate mark is prone to abrasion, single in function and incapable of being repaired after being damaged are solved.

There are provided a compound which, while being a curable resin, can easily exhibit easy dismantlability, repairability, and remoldability when being in the form of a cured product, a curable resin composition obtained using the same; and a cured product thereof. Specifically, there is used a glycidyl ether group-containing compound in which a structural unit A having one or more glycidyl ether groups and a structural unit B different from the structural unit A are linked in A-B-A, the structural unit A contains a maleimide structure and the structural unit B contains a furan structure, and the structural unit A and the structural unit B are bonded by a reversible bond formed by a Diels-Alder reaction.

Process to create a thermal reversible crosslinking polypropylene system in the molten state, comprising at least the following step a) functionalization of a polypropylene grafted maleic anhydride (PPgMA) having a molecular weight of at least 9 kg / mol with an amine b) Crosslinking the functionalized polypropylene with bismaleimide to form a Diels Alder system.

The invention relates to a transparent dynamic covalent cross-linked polyurethane plate capable of being processed and remolded and a preparation method of the transparent dynamic covalent cross-linked polyurethane plate. The transparent dynamic covalent cross-linked polyurethane plate comprises the following raw material components: polyisocyanate, a polyol chain extender, a functional cross-linking agent, a solvent and a catalyst, the plate structurally comprises at least one of boric acid ester with a thermal stimulation response function, Diels-Alder reaction, thiocarbamate bonds, oxime urethane bonds, disulfide bonds, imine bonds and carbamate bonds. According to the invention, dynamic covalent bonds with thermal response characteristics are introduced into cross-linking points, and the cross-linked polyurethane plate with high transparency, high mechanical strength and reversible processability is constructed through interaction and synergy with rich hydrogen bonds in polyurethane.

The invention relates to a preparation process of a light-transmitting metal plastic part, and belongs to the technical field of composite materials. A diene monomer is introduced into matrix resin by using a modified monomer, cesium-tungsten bronze is modified, dienophile is introduced into the surface of cesium-tungsten bronze, and material repair is realized by using Diels-Alder reaction, so that the dispersity of cesium-tungsten bronze and the binding capacity of cesium-tungsten bronze and matrix resin are effectively improved; in addition, the cesium-tungsten bronze has an extremely strong absorption effect on ultraviolet light and infrared light, the infrared band in sunlight carries most heat and has an extremely strong heat effect, and the cesium-tungsten bronze can effectively absorb energy in the infrared light and convert the energy into heat energy, so that the heat-resistant performance of the material is improved. The temperature of the area where the material is located is increased, so that the reaction rate of the Diels-Alder reaction is effectively increased, and the self-repairing speed of the material under sunlight is increased.

The invention belongs to the technical field of polymer insulating materials, and particularly discloses an insulating paint composition, a preparation method thereof and application of an enameled wire. The insulating paint composition comprises the following components in parts by weight: 100 parts of polymer resin, 5-10 parts of microcapsules, 15-35 parts of auxiliaries and a solvent, the core material of the microcapsule is Lewis acid, and the wall material of the microcapsule is polyurea formaldehyde or polyurethane. And the polymer resin is a polyester or polyamide-imide of which the tail end is grafted with a Diels-Alder adduct. A paint film formed by the composition disclosed by the invention can keep the stability of a cross-linked network during high-temperature working, and can activate the recombination of Diels-Alder dynamic bonds under the mild condition of relatively low damage to the paint film when the paint film needs to be repaired; and the structural stability in a high-temperature working environment and the repairability under a mild condition after damage can be realized at the same time.

The invention relates to the technical field of chemical reaction engineering, and discloses a continuous production and preparation method and system of methyl tetrahydrophthalic anhydride, and the method comprises the following steps: establishing a three-stage DielsAlder reactor of dehydrated amount methyl cyclopentadiene and filtered maleic anhydride, preheating and mixing the dehydrated amount methyl cyclopentadiene and the filtered maleic anhydride based on the first stage of the three-stage DielsAlder reactor, and carrying out continuous production and preparation on the dehydrated amount methyl cyclopentadiene and the filtered maleic anhydride based on the second stage of the three-stage DielsAlder reactor; a mixed reactant is obtained; carrying out catalytic reaction on the mixed reactant by utilizing the second stage of the three-stage DielsAlder reactor to obtain a catalytic reaction compound, and carrying out ionic liquid catalytic enhancement on the catalytic reaction compound by utilizing the third stage of the three-stage DielsAlder reactor to obtain an enhanced reaction compound; recording the infrared spectrum of the enhanced reaction compound to calculate the MCPD conversion rate of the enhanced reaction compound, desolventizing the enhanced reaction compound to obtain methyl tetrahydrophthalic anhydride, and isomerizing the methyl tetrahydrophthalic anhydride to obtain the target methyl tetrahydrophthalic anhydride. According to the invention, the preparation efficiency of methyl tetrahydrophthalic anhydride can be improved.

The present invention discloses nucleotide analogs and their application in sequencing. In the first aspect of the present application, a compound having a structural formula as shown in formula (I) is provided. The compound introduces an orthogonal cleavage group on the nucleotide, so that when it is incorporated into a primer as a replacement for a reversible terminator for extension, the orthogonal cleavage group as a protecting group can be quickly removed through an inverse electron demand Diels-Alder (IEDDA) reaction, thereby exposing 3′-OH for the next round of biochemical reactions, greatly shortening the reaction time in the sequencing process, reducing the phasing value, and ultimately reducing the error rate in the sequencing process and improving the accuracy of sequencing.

Embodiments of the present disclosure relate to heterogeneous catalyst compositions formed from the use of a crystalline porous metal organic framework (MOF) that reacts with a phosphorus ligand in a reverse electron demand Diels-Alder reaction to produce a heterogeneous catalyst precursor. The heterogeneous catalyst precursor is then reacted with a Group VIII transition metal catalyst precursor compound to form a heterogeneous catalyst composition that can be used in reactions such as hydroformylation of olefins.

Provided are: a compound which is a curable resin and which can easily achieve easy disintegration, reworkability, remoldability and the like in a cured product; a curable resin composition which is obtained using the compound; and a cured product of the curable resin composition. Specifically disclosed are: a curable compound which is characterized by having a curable functional group at an end of a linear polymer and further having a maleimide structure in a side chain; a curable compound in which a conjugated diene compound is reversibly bonded to the maleimide structure by a Diels-Alder reaction; and a curable resin composition which is characterized by containing the curable compound and a compound that is reactive with a curable functional group at the terminal.

A resin composition for forming a structural element such as a flooring panel includes a resin system including: 45-60 wt % of a plant-derived polyfurfuryl alcohol resin; up to 15 wt % of a non-structural filler such as talc or jute fibre; and 35-40 wt % of a glass fibre. 5 A method of making the structural element includes mixing the resin and filler to produce the resin system; laying up multiple layers of the resin system and the glass fibre in a mould; subjecting the mould to an initial heating profile in an initial resin curing step so that the resin system undergoes a condensation reaction and such that substantially all of the water produced in the condensation reaction has been removed, wherein the heating profile comprises a first, an intermediate, and a final temperature. The product is subsequently subjected to a post-curing step comprising a Diels-Alder reaction.

The invention belongs to the technical field of petroleum resin preparation, and relates to a preparation method of hydrogenated petroleum resin based on D-A reaction toughening. Specifically, conjugated diene and a dienophile are subjected to a Diels-Alder reaction to generate a prepolymer monomer with a cyclohexene structure, cationic polymerization of the prepolymer is initiated under catalysis of a Lewis acid catalyst, a molecular chain is further increased, a D-A polymer with higher molecular weight and a specific branched structure is obtained, and deep hydrogenation is performed to obtain the high-molecular-weight and high-molecular-weight D-A polymer with a specific branched structure. The fully saturated hydrogenated petroleum resin with a rigid alicyclic structure and a flexible ester group side chain is obtained. The hydrogenated petroleum resin has good thermodynamic properties, mechanical properties and aging resistance which are synergistically optimized, meets the technical requirements of high polymer material additives, and has remarkable strategic development potential and market competitiveness in the field of refined, functionalized and green chemical materials.

The present invention relates to homogeneous antibody-conjugates with high payload loading (high DAR) obtained by site-specific conjugation with a single antibody N-glycan. The conjugates according to the invention are homogeneous, i.e., with a DAR equal to or close to the theoretical DAR and narrow distribution, and do not require any genetic modification to the antibody. The invention also relates to a modular, non-genetic preparation method for such a conjugate, which method comprises three simple steps and can start from any antibody. These steps are (a) enzymatic remodeling of the glycan to give antibodies functionalised per antibody with two or four click probes, (b) strain-promoted cycloaddition with a multivalent bifunctional reagent comprising a cyclic alkyne and at least two click probes that are not reactive to the cyclic alkyne, and (c) strain-promoted cycloaddition with a multivalent bifunctional reagent comprising at least one cyclic alkyne and at least two click probes that are not reactive to the cyclic alkyne. And (c) subjecting the click probes to reverse electron demanding Diels-Alder cycloaddition with branched linker-drug constructs comprising a cyclic alkyne or strained olefin, linked to one or more payloads, preferably by cleavable linkers. The resulting conjugates have a DAR of 6 or higher, are rapidly generated, have high homogeneity and surprising stability. In addition, the HIC profile of the resulting ADC shows a relatively short retention time, and thus shows a very high potential in targeting tumor cells and / or treating cancer.

The invention belongs to the technical field of high polymer materials, and particularly relates to thermally reversible cross-linked epoxidized SBS and a preparation method thereof. The preparation method comprises the following steps: a, dissolving SBS in an organic solvent, adding formic acid and hydrogen peroxide, and carrying out epoxidation reaction to generate ESBS; b, ESBS is dissolved in an organic solvent and then reacts with furfuryl amine, a furan group is grafted, ESBS-FA is obtained, and the dosage of furfuryl amine is 2-6% of the weight of ESBS; and c, carrying out crosslinking on the ESBS-FA and bismaleimide through Diels Alder reaction, and reacting for 12 to 24 hours at the temperature of 120 to 150 DEG C, so as to obtain the thermally reversible crosslinked epoxidized SBS. The preparation method has the beneficial effects that an epoxy group is introduced through epoxidation modification, a furan group is further grafted, a dynamic cross-linked network is formed through a DA reaction with bismaleimide (BMI), and through establishment of a thermally reversible dynamic covalent bond, the mechanical property and the temperature resistance of an SBS system are improved, and meanwhile, the processability of SBS is reserved.

The application discloses a multifunctional backbone molecule for controllable and visual monitoring of drug release and a preparation method and application thereof, the multifunctional backbone molecule has a structure shown in formula I, includes a tetrazine structural unit and a phenanthrene dioxin skeleton, and fluorescence of the phenanthrene dioxin is quenched through fluorescence resonance energy transfer effect between the tetrazine and the phenanthrene dioxin parent nucleus. The multifunctional backbone molecule provided by the application can be subjected to a reverse electron demand Diels-Alder bioorthogonal bond cleavage reaction with a prodrug modified by a trans-cyclooctene, 3-isocyanopropyl or 3-isocyanopropyl-1-carbamoyl group, so that the quenching effect is destroyed, fluorescence is recovered, the prodrug is activated, controllable release and visual monitoring of the drug are realized. In addition, the multifunctional backbone molecule provided by the application can be connected with a targeting group on the phenanthrene dioxin skeleton, so that controllable release of the drug at a target site and real-time visual monitoring of the drug release are realized.

To provide a resin of at least one of an aromatic polycarbonate and a polyarylate having a new structure, which does not contain a radical initiator, a reaction catalyst or the like causing deterioration of electric characteristics, further can be produced without using UV, an electron beam or the like deteriorating a charge transport material (CTM), and does not substantially contain a polymer of only a single component when there are multiple polymerizable components.SOLUTION: A resin is at least one resin selected from a group consisting of an aromatic polycarbonate and a polyarylate, in which the resin has a bond between polymer chains due to a Diels-Alder reaction.SELECTED DRAWING: None

Provided are: a compound which is a curable resin, but which can easily achieve easy disintegration, reworkability, remoldability, and the like in a cured product; a curable resin composition using the compound; and a cured product of the curable resin composition. Specifically disclosed are: a curable compound which is characterized by having a curable functional group at an end of a linear polymer having a flexible structure and further having a conjugated diene structure in a side chain; a curable compound which is obtained by reversibly bonding a dienophile compound to the conjugated diene structure by means of a Diels-Alder (Diels-Alder) reaction; and a curable resin composition which is characterized by containing the curable compound and a compound that is reactive with a curable functional group at the terminal.

A composition includes an underfill comprising a polymer having monomer units with substituted Diels-Alder moieties and ester moieties. A first process includes obtaining an underfill comprising a polymer having monomer units with substituted Diels-Alder moieties and ester moieties. A second process includes providing a mixture that includes a curing agent and a monomer comprising substituted Diels-Alder moieties and ester moieties. The second process also includes curing the mixture to form the underfill. A third process includes providing a semiconductor device that includes the underfill. A semiconductor device includes the underfill.

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of a chiral dihydroquinolone compound. The application utilizes N-heterocyclic carbene (NHC) as a catalyst, and generates the chiral dihydroquinolone through a nitrogen hetero-diene Diels-Alder reaction of a chloroaldehyde and an azo-ortho-benzoquinone precursor under the action of NHC and an alkaline reagent. The preparation method of the application does not need to use a transition metal as a catalyst, can perform a reaction under relatively mild conditions, and has the advantages of green environmental protection, low cost, wide substrate selectivity, mild reaction conditions and the like. In addition, by optimizing the reaction conditions of the preparation method, the product has high yield, high purity, unique cis selectivity and excellent enantioselectivity. The application provides a new route and new idea for the chiral dihydroquinolone compound, can play an important role in the fields of drug intermediates and the like, and has good application value and potential.

The invention belongs to the technical field of material science and functional polymer materials, and particularly relates to a preparation method of a puncture-resistant aerogel heat-sealing film with a self-repairing function, which comprises the following steps: constructing a polyvinylpyrrolidone nanofiber sacrificial template through electrostatic spinning; generating a silicon dioxide aerogel network by an in-situ sol-gel method; removing the template through solvent extraction to obtain a continuous aerogel skeleton; introducing a furanized polyurethane and maleimide cross-linking agent precursor solution through vacuum infiltration; thermally initiating Diels-Alder reaction to form a dynamic covalent bond cross-linked polymer network; and finally carrying out hot-press molding. By the adoption of the technical scheme, collaborative optimization of heat insulation performance and mechanical performance can be achieved, the film is endowed with excellent puncture resistance and a heat triggering self-repairing function, and meanwhile the film has good heat sealing processability.

The invention relates to a method for providing pyridazines by fast oxidation of dihydropyridazines. The pyridazines can be used in treatments such as radiotherapy, diagnostics, imaging and other photochemical methods. The method is suitable for dihydropyridazine mixtures generated by a click reaction between a first chemical entity which is a 1,2,4,5-tetrazine or a strained alkene with retro Diels-Alder cycloaddition reactivity and a second chemical entity which is a 1,2,4,5-tetrazine or a strained alkene with complementary retro Diels-Alder cycloaddition reactivity. The linkage between the first chemical entity and the second chemical entity is followed by fast acid catalyzed oxidation.

Described herein is a dual-functional tetrazine–allyl reagent that enables site-selective disulfide modification in peptides and proteins, serving both as a Michael acceptor for bis-thiols and as a reactive handle for Inverse Electron-Demand Diels–Alder (IEDDA) click chemistry to introduce functional payloads.

In one aspect, compositions are described herein. A composition described herein comprises a nanoparticle, a therapeutic species, and a linker joining the nanoparticle to the therapeutic species. The linker joining the nanoparticle to the therapeutic species comprises a Diels-Alder cyclo-addition reaction product. Additionally, in some embodiments, the nanoparticle is a magnetic nanoparticle.

The invention relates to the technical field of processing aids, in particular to a high-dispersity PPA polymer processing aid and a preparation method thereof, and the high-dispersity PPA polymer processing aid comprises carrier resin, a modified fluorine-containing polymer, a modified amphiphilic block copolymer, tetra [3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionic acid] pentaerythritol ester, tris (2, 4-di-tert-butylphenyl) phosphite ester and polyethylene wax. The fluorine-containing polymer is modified to migrate to a metal-melt interface in a high-temperature melting stage, so that a lubricating layer is formed, and the processing flowability is improved; in the cooling stage, the Diels-Alder addition reaction is carried out in the forward direction to generate a bridge ring, and the modified fluorine-containing polymer is fixed on the processed product resin, so that the problem that an auxiliary agent is left on the surface of equipment is solved; 4 [3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionic acid] pentaerythritol ester and tris (2, 4-di-tert-butylphenyl) phosphite protect the furan group and the maleimide group from intact state to the cooling stage.

The invention provides an industrial production method of high-purity methyl nadic anhydride, and belongs to the technical field of organic chemical synthesis and fine chemical engineering. In order to solve the problems of low product purity and unstable yield caused by impure raw materials, the method comprises the following steps: carrying out pretreatment purification on a methylcyclopentadiene dimer raw material, including thermal depolymerization, rapid cooling and rectification separation, so as to obtain a high-purity methylcyclopentadiene monomer; dissolving maleic anhydride in an inert solvent, then adding the monomer, and carrying out Diels-Alder addition reaction to obtain a crude product; and rectifying and purifying the crude product to obtain the high-purity methyl nadic anhydride. According to the invention, the high-purity product can be stably obtained, the material recycling is realized, the production efficiency is improved, and the cost is reduced.

A resin composition for forming a structural element, such as a floor panel, comprises a resin system comprising: 45-60% by weight of a polyfurfuryl alcohol resin of plant origin; up to 15% by weight of a non-structural filler such as talc fibers or jute fibers; and 35 to 40 wt% of glass fibers. A method of making the structural element comprises: mixing the resin and a filler to produce the resin system; laying a plurality of layers of the resin system and the glass fibers in a mold; in an initial resin curing step, the mold is subjected to an initial heating profile such that the resin system undergoes a condensation reaction and such that substantially all of the water generated in the condensation reaction is removed, where the heating profile comprises a first temperature, an intermediate temperature and a final temperature. The product is then subjected to a post-curing step including a Diels-Alder reaction.