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Determination method of carbomer content in gel containing carbomer

A technology of carbomer gel and determination method, which is applied in the field of determination of carbomer content, can solve the problems of slow reaction speed, long titration process, and difficulty in determining the titration end point, and achieves simple and good reproducibility of experimental instruments and reagents. Sexual, well-designed effects

Active Publication Date: 2017-11-07
成都英诺新科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the course of the experiment, it was found that direct titration with metal ions has a slow reaction rate, and the reaction process is also accompanied by a hydrolysis process. The titration process is relatively long, resulting in insensitive indicator color change and difficult determination of the titration end point, so it cannot be accurately determined. Pom Carboxylic Acid Group Content

Method used

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  • Determination method of carbomer content in gel containing carbomer
  • Determination method of carbomer content in gel containing carbomer
  • Determination method of carbomer content in gel containing carbomer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] 1. Preparation of Carbomer Gel:

[0059] 1) The process prescription is:

[0060]

[0061] 2) Preparation process:

[0062] Take 30% of the prescribed amount of water, add carbomer, stir to disperse it evenly, let it swell fully, stir, and add sodium hydroxide solution to the solution at the same time, adjust the pH to 6.0, continue to stir to form a gel, which is A; Take another 20% of the prescribed amount of water, add hydroxyethyl cellulose, stir to form a uniform suspension, add propylene glycol, stir well, add to liquid A, add water to the full amount of the prescription, and stir to form a gel. The prepared gel was dispensed into 10 g tubes, and sterilized at 121° C. for 15 minutes. spare.

[0063] In the following assay methods, the reagents used are as follows:

[0064] 1mol / L sodium hydroxide solution

[0065] 0.5% calcium chloride solution (concentration is 0.046mol / L)

[0066] 0.05mol / L EDTA titration solution (concentration is 0.05002mol / L)

[006...

Embodiment 2

[0104] 1. Preparation of tea polyphenol oral gel:

[0105] 1) The process prescription is:

[0106]

[0107] 2) Preparation process:

[0108] Take 30% of the prescription water, add carbomer, stir to disperse evenly, let it swell fully, then add triethanolamine, adjust the pH to 5.5, continue to stir to form a gel, and it is solution A; take another appropriate amount of water, add After the tea polyphenol is dissolved, transfer it to the above solution A; take ethylparaben, add glycerin to dissolve it, then add it to the above solution A, stir well, add water to the full amount of the prescription, and stir evenly.

[0109] In the following assay methods, the reagents used are as follows:

[0110] 1mol / L potassium hydroxide solution

[0111] Zinc chloride solution (concentration is 1.0012mol / L)

[0112] 0.3mol / L EDTA titration solution (concentration is 0.3001mol / L)

[0113] 2. Determination of carbomer content:

[0114] Take 10g of the above gel, weigh it accurately...

Embodiment 3

[0149] 1. Preparation of levofloxacin hydrochloride ophthalmic gel:

[0150] 1) The process prescription is:

[0151]

[0152] 2) Preparation process:

[0153] Take 40% of the prescribed amount of water, add carbomer, stir to disperse it evenly, let it swell fully, then add triethanolamine, adjust the pH to 6.5, and continue stirring to form a gel, which is solution A; take another appropriate amount of water, add After levofloxacin hydrochloride is dissolved, transfer it to the above solution A; take ethylparaben, add glycerin to dissolve it, then add it to the above solution A, stir well, add polysorbate, stir, add water to the full amount of the prescription, and stir evenly.

[0154] In the following assay methods, the reagents used are as follows:

[0155] 0.1mol / L potassium hydroxide solution

[0156] Magnesium chloride solution (concentration is 0.1003mol / L)

[0157] 0.01mol / L EDTA titration solution (concentration is 0.01001mol / L)

[0158] 2. Determination of c...

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Abstract

The invention relates to a determination method of carbomer content in gel containing carbomer. The determination method is characterized by comprising the following steps: adding a certain amount of an alkaline solution to enable a carboxylic acid group of the carbomer in the gel to exist at an ion state; then adding an excessive amount of a metal salt solution and sufficiently mixing metal salt and the carboxylic acid group in the carbomer to generate a complex; after removing the complex, titrating unbound metal salt by utilizing an EDTA (Ethylene Diamine Tetraacetic Acid) titrating solution, so as to calculate the content of the carbomer in a sample. The method provided by the invention is applicable to detection of the carbomer content in the gel which takes the carbomer as a gel matrix or a main component; the method is simple and accurate and has strong specificity.

Description

technical field [0001] The present invention relates to a kind of assay method of carbomer content, particularly relate to a kind of assay method taking carbomer as gel matrix or main component in the gel of carbomer content. Background technique [0002] Gel is a thick liquid or semi-solid preparation of uniform, suspension or emulsion type made of medicine and gel-forming excipients. As a new type of pharmaceutical preparation, it is widely used in new drug delivery systems such as sustained release and controlled release, and can be administered from various routes such as skin, eye mucosa, oral cavity, nasal cavity, vagina, and rectum. Because the gel has good biocompatibility and stability, is easy to apply, and is easy to absorb after local administration, it has good application value and prospects in clinical practice. [0003] In order to make the gel preparation have suitable spreadability and ease of application, the matrix of the gel agent needs to have certain ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78G01N31/16
CPCG01N21/78G01N31/16
Inventor 王奎郭沛琳郭建琼祝国华王楠李克江刘成
Owner 成都英诺新科技有限公司
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