Cefquinome sulfate injection and low-temperature high-shear preparation method thereof
A technology for cefquinoxime sulfate and injection, which can be applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. and other problems, to achieve the effect of simple preparation steps and easy operation
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Embodiment 1
[0035] Prepare cefquinome sulfate injection, comprising the steps:
[0036] (1) Weigh each component according to the following mass percentage, and set aside;
[0037] Cefquinome Sulfate 2.3%,
[0038] Lecithin 1.0%,
[0039] Aluminum stearate 2.0%,
[0040] The balance is ethyl oleate;
[0041] (2) High temperature sterilization and cooling of auxiliary materials;
[0042] Add 85% ethyl oleate into the liquid mixing tank, then add the formulated amount of aluminum stearate and lecithin, and stir evenly; heat to 121°C, keep constant temperature, and continue stirring for 30 minutes (the maximum temperature should not exceed 130°C) ; Circulate cold water into the interlayer of the liquid distribution tank, after cooling down to 50°C, slowly add the prescribed amount of cefquinoxime sulfate, and stir until uniform while adding; then use ethyl oleate to make up the volume, and stir evenly;
[0043] (3) Cefquinome sulfate is subjected to low temperature and high shear to obt...
Embodiment 2
[0048] Prepare cefquinome sulfate injection, take each component by the following mass percentages, and set aside;
[0049] Cefquinome Sulfate 2.4%,
[0050] Lecithin 1.0%,
[0051] Aluminum stearate 2.0%,
[0052] Add ethyl oleate to the full amount;
[0053] All the other preparation methods are the same as in Example 1.
Embodiment 3
[0055] Prepare cefquinome sulfate injection, take each component by the following mass percentages, and set aside;
[0056] Cefquinome Sulfate 2.5%,
[0057] Lecithin 1.0%,
[0058] Aluminum stearate 2.0%,
[0059]Add ethyl oleate to the full amount;
[0060] All the other preparation methods are the same as in Example 1.
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