Cosmetic composition for containing nicotinoyl peptide and fermented natural extracts

A technology of cosmetic composition and fermented product, which is applied in the direction of cosmetics, medical preparations containing active ingredients, cosmetic preparations, etc., which can solve the problems of non-functionality and easy deterioration of cosmetic compositions, and achieve excellent wrinkle improvement effect and smooth skin. Excellent whitening effect and increased skin improvement effect

Inactive Publication Date: 2017-11-21
AMI COSMETIC CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] However, although cosmetic raw materials derived from natural products are environmentally friendly, they are easily deteriorated in c

Method used

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  • Cosmetic composition for containing nicotinoyl peptide and fermented natural extracts
  • Cosmetic composition for containing nicotinoyl peptide and fermented natural extracts
  • Cosmetic composition for containing nicotinoyl peptide and fermented natural extracts

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preparation example Construction

[0040] The preparation method of the above-mentioned oligopeptide is as follows: After extracting the protein in the living body, it is treated with protease to reduce its molecular weight, or it can be prepared biologically by using a gene recombination and protein expression system, or it can be prepared by using a peptide synthesizer, etc. Prepared by chemical synthesis.

[0041] Specifically, the above-mentioned oligopeptides can be prepared through the following steps, that is, step a, using the usual solid phase peptide synthesis (solid phase peptide synthesis, SPPS) to obtain NH 2 - protected peptide-resin; step b, making the acquired NH 2 - reacting the protected peptide-resin with niacin; and step c, removing the resin. In the case where there is a functional group in the side chain of the amino acid residue forming the above-mentioned oligopeptide, in the above-mentioned step a, the amino acid whose above-mentioned functional group is protected can be used to synthe...

preparation example 1

[0080] Preparation Example 1: Preparation of Nicotinyl Pentapeptide (YGGFM)

[0081] Pentapeptides are usually synthesized by using 9-fluorenylmethoxycarbonyl (9-fluorenylmethoxycarbonyl; Fmoc) as a protecting group for amino acids in solid-phase peptide synthesis, and N-hydroxybenzotriazole (N-hydroxybenzotriazole; HOBt ) and N, N-diisopropylcarbodiimide (N, N'-diisopropylcarbodiimide; DIC) were used as activators to extend amino acid residues (references: Wang C. Chan, Perter D. White, 'Fmoc- solid phase peptide synthesis', Oxford).

[0082] In the synthetic NH 2 - Add 20% piperidine / N-methylpyrrolidone solution to the protected peptide (YGGFM) resin to remove the 9-fluorenylmethoxycarbonyl group combined with the amino group, and use N-methylpyrrolidone (N-methyl-2 - After washing with pyrrolidone (NMP) and dichloromethane (dichloromethane: DCM), the coupling reaction was carried out with 5 equivalents of nicotinic acid (nicotinic acid) for 12 hours at room temperature. ...

preparation example 2

[0085] Preparation Example 2: Preparation of Nicotinyl-nonapeptide (YGGFLRKYP)

[0086] NH was synthesized according to the method described in Example 1 above 2 -Protected peptide (YGGFLRKYP)-resin.

[0087] In the synthesis of the above NH 2 - Add 20% piperidine / N-methylpyrrolidone solution to the protected peptide (YGGFLRKYP) resin to remove the 9-fluorenylmethoxycarbonyl group bound to the amino group, and wash with N-methylpyrrolidone and dichloromethane , at room temperature, the coupling reaction was carried out with 5 equivalents of nicotinic acid for 12 hours. After the reaction, it was washed several times with N-methylpyrrolidone and dichloromethane and dried.

[0088] At room temperature, using a mixed solution of trifluoroacetic acid: phenol: thioanisole: water: ethanedithiol (82.5: 5: 5: 5: 2.5 (v / v)) to make the dried nicotinoyl-nonapeptide -The resin was reacted for 2 to 3 hours to remove the tert-butoxycarbonyl group, and after separating the nicotine-no...

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Abstract

The present invention provides a cosmetic composition containing nicotinamide, galactomyces fermented matter, and lactobacillus fermented matter as active ingredients.

Description

technical field [0001] The present invention relates to a cosmetic composition for skin whitening and wrinkle improvement containing nicotinoyl peptide (NICOTINOYL PEPTIDE). Background technique [0002] With the development of industry and serious environmental pollution, skin aging prevention and whitening have attracted much attention. In particular, human skin is constantly undergoing changes, the most typical changes being the decline of skin function and loss of visual beauty caused by aging. The final phenomenon of skin aging as a result of skin appearance is the formation of wrinkles, decreased skin elasticity, and the formation of age spots, and the most typical phenomenon is the formation of wrinkles. [0003] Skin aging can be divided into two types: intrinsic (chronological aging) and photoaging (phtoaging) (Gilchrest BA: J. Am. Acad. Dermatol., 21, 610-613 (1989)). Endogenous aging refers to the aging phenomenon that is naturally induced by the decrease of the...

Claims

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Application Information

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IPC IPC(8): A61K8/99A61K8/9794A61K8/9789A61K8/64A61Q19/02A61Q19/08
CPCA61K8/64A61K8/97A61K8/99A61Q19/02A61Q19/08A61K8/02A61K2800/85
Inventor 李坰绿韩秉锡金秀颖牟相炫徐孝铉
Owner AMI COSMETIC CO LTD
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