Gas phase nicotine calibrating apparatus and method thereof

Abstract

The invention provides a gas phase nicotine calibrating apparatus and a method thereof. The apparatus comprises an air compressor, a steam-water separator, an up and a down air channel, a high temperature evaporating chamber, and a low temperature condensation chamber; a buckle shaped pipe is inserted between the evaporating chamber and the condensation chamber, the upper air channel is communicated with a straight pipe of the buckle shaped pipe which is inserted in the evaporating chamber, and the down air channel enters the evaporating chamber through a normal bend and a pipe orifice is located below the liquid level. Calibration of concentration of nicotine in the solution after the solvent is evaporated at different temperatures can be realized, that is by means of a temperature difference between the evaporating chamber and the condensation chamber, high temperature gas phase nicotine molecules and high temperature propylene glycol molecules are condensed into liquid phase in the condensation chamber, a citric acid-ethanol solution in the condensation chamber is used for absorbing nicotine and propylene glycol, and excellent dissolvability of CH2Cl2 for nicotine is used for extracting nicotine; finally, quinoline is used as an internal standard substance in order to carry out gas chromatograph, and evaporation concentrations of nicotine in a nicotine-propylene glycol system under the condition with different temperatures can be calculated.

Description

technical field

[0001] The invention relates to the field of nicotine collection and detection, in particular to a gas-phase nicotine calibration device and a method thereof. The invention can realize the calibration of the nicotine concentration in a solution obtained after solvent evaporation at different temperatures. Background technique

[0002] Tobacco contains a variety of alkaloids, among which nicotine (also known as nicotine, chemical name 1-methyl-2-(3-pyridyl) pyrrolidine) has the highest content, accounting for about 95% of the total tobacco alkaloids. Pure nicotine is a colorless or light yellow oily liquid at room temperature, with a boiling point of 246.7°C (99.1kPa) and a relative density of 1.0097 (20 / 4°C). It is miscible with water when it is lower than 60°C, and easily soluble in alcohol, ether, chloroform and petroleum ether. With water vapor can be volatile. Studies have shown that there are three forms of nicotine molecules: non-protonated, single-pr...

Examples

Embodiment 1

[0023] The device of the present invention will be further described below in conjunction with the accompanying drawings:

[0024] Such as figure 1 As shown: a gas-phase nicotine calibration device, including an air compressor 1, a steam-water separator 2 connected through pipelines, an upper and lower gas circuit divided into two paths through a three-way valve 3, a closed high-temperature evaporation chamber 9 and Closed low-temperature condensation chamber 12, a button-shaped tube is inserted between the closed-type high-temperature evaporation chamber and the closed-type low-temperature condensation chamber, and the button-shaped tube is composed of a horizontal tube and vertical tubes extending downward along both ends of the horizontal tube , and the mouth of the vertical tube of the button tube located in the evaporation chamber is located above the liquid surface, the mouth of the vertical tube of the button tube located in the condensation chamber is located below the...

Embodiment 2

[0030] Further description will be given below in conjunction with the evaporation of nicotine in the nicotine-propylene glycol system under different temperature conditions.

[0031] combined with figure 2 For further clarification:

[0032] The figure is a gas chromatogram of a gas-phase nicotine solution obtained by evaporating at 70° C. for four hours by the method of the present invention. The substance at the retention time of 5.276min is the internal standard quinoline, the substance at the retention time of 6.688min is nicotine, and the addition amount of the internal standard quinoline is 21.86μg, so the quality of nicotine obtained is about 4.17μg, as shown in the following table:

[0033] name

technical field

[0001] The invention relates to the field of nicotine collection and detection, in particular to a gas-phase nicotine calibration device and a method thereof. The invention can realize the calibration of the nicotine concentration in a solution obtained after solvent evaporation at different temperatures. Background technique

[0002] Tobacco contains a variety of alkaloids, among which nicotine (also known as nicotine, chemical name 1-methyl-2-(3-pyridyl) pyrrolidine) has the highest content, accounting for about 95% of the total tobacco alkaloids. Pure nicotine is a colorless or light yellow oily liquid at room temperature, with a boiling point of 246.7°C (99.1kPa) and a relative density of 1.0097 (20 / 4°C). It is miscible with water when it is lower than 60°C, and easily soluble in alcohol, ether, chloroform and petroleum ether. With water vapor can be volatile. Studies have shown that there are three forms of nicotine molecules: non-protonated, single-pr...

Examples

Embodiment 1

[0023] The device of the present invention will be further described below in conjunction with the accompanying drawings:

[0024] Such as figure 1 As shown: a gas-phase nicotine calibration device, including an air compressor 1, a steam-water separator 2 connected through pipelines, an upper and lower gas circuit divided into two paths through a three-way valve 3, a closed high-temperature evaporation chamber 9 and Closed low-temperature condensation chamber 12, a button-shaped tube is inserted between the closed-type high-temperature evaporation chamber and the closed-type low-temperature condensation chamber, and the button-shaped tube is composed of a horizontal tube and vertical tubes extending downward along both ends of the horizontal tube , and the mouth of the vertical tube of the button tube located in the evaporation chamber is located above the liquid surface, the mouth of the vertical tube of the button tube located in the condensation chamber is located below the...

Embodiment 2

[0030] Further description will be given below in conjunction with the evaporation of nicotine in the nicotine-propylene glycol system under different temperature conditions.

[0031] combined with figure 2 For further clarification:

[0032] The figure is a gas chromatogram of a gas-phase nicotine solution obtained by evaporating at 70° C. for four hours by the method of the present invention. The substance at the retention time of 5.276min is the internal standard quinoline, the substance at the retention time of 6.688min is nicotine, and the addition amount of the internal standard quinoline is 21.86μg, so the quality of nicotine obtained is about 4.17μg, as shown in the following table:

[0033] name

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