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Application of albiflorin to preparation of melatonin system function improving products

A paeonifloride glycoside and system function technology, applied in the field of medicine, can solve the problems that melatonin cannot achieve the expected effect, reduce the secretion of endogenous melatonin, and damage the system function, so as to promote endogenous melatonin hormone secretion, improve melatonin system function, increase the effect of activity and content

Inactive Publication Date: 2017-12-01
张作光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, due to the short half-life of exogenous melatonin in the body, the biological effect of the body solely relying on the supplementation of exogenous melatonin is limited, and long-term large intake of melatonin will further reduce the body's endogenous melatonin production. secretion
In addition, the function of the melatonin system is completed by the interaction of melatonin through the melatonin receptor. For the impairment of the system function caused by the down-regulation of the melatonin receptor function and the lack of secretion, only supplementing exogenous melatonin and Can't achieve expected effect

Method used

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  • Application of albiflorin to preparation of melatonin system function improving products
  • Application of albiflorin to preparation of melatonin system function improving products
  • Application of albiflorin to preparation of melatonin system function improving products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0049] Implementation Case 1: Effect of Paeonifloride on the Function of Melatonin System in CUMS Rats

[0050] In our research on the mechanism of action of paeonifloride on anti-stress, anti-depression, improving sleep and cognitive function by using a new generation of targeted metabolomics technology, we found that the chronic unpredictable mild stress model (chronic unpredictable mild stress, CUMS ) Rat hippocampal serotonin, melatonin, melatonin receptors, dopamine secretion are inhibited, paeonifloride administration (7mg / kg) 7 days later:

[0051] 1.1 The content of kynuric acid and quinolinic acid in the hippocampus of chronic stress rats was significantly reduced, indicating that the metabolic pathway of kynuric acid was down-regulated, while the content of serotonin and melatonin in the hippocampus was significantly increased, indicating that the metabolic pathway of serotonin and melatonin raised, see attached figure 1 .

[0052] 1.2 Paeonifloride can significa...

Embodiment example 2

[0063] Implementation Case 2: Effect of Paeonifloride on Learning and Memory Function of CUMS Rats

[0064] 2.1 The effect of paeonifloride glycosides on the opening activity of rats with chronic stress

[0065] After 21 days of chronic stress, rats were successfully modeled, and paeonifloride (7mg / kg) was administered orally for 7 days to conduct an open-field activity experiment. The number of times was significantly reduced, and compared with the blank control group, there was a significant difference (P<0.01), see Table 3. After 7 days of administration, there were significant differences between the fluoxetine group, the paeonifloride group and the model group (P<0.05 or P<0.01), suggesting that paeonifloride had a significant effect on the learning and memory impairment of the tested rats. Improvement effect.

[0066] Table 3 Rat opening behavior comparison (mean ± s, n = 8)

[0067]

[0068] ##P<0.01 compared with the control group; **P<0.01 compared with the mode...

Embodiment example 3

[0074] Implementation Case 3: Effect of Paeonifloride on Learning and Memory Function of Scopolamine Dementia Mice

[0075] After the mice were intraperitoneally injected with scopolamine hydrobromide to prepare the learning and memory impairment dementia model, the water maze test was performed, and the swimming time (ie escape latency) and swimming distance of the mice after entering the water to find the platform were used as observation indicators. The experimental results showed that: compared with the model group, the escape latency of the paeonifloride group on the 4th and 5th day was significantly shortened (P<0.05), see Table 5; The daily swimming distance was shortened (P<0.05), see Table 6. The results of this experiment show that paeonifloride can significantly improve the learning and memory ability of scopolamine-induced dementia model mice.

[0076] Table 5 The effect of paeonifloride glycosides on the escape latency of scopolamine-induced dementia model mice (...

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Abstract

The invention provides an application of albiflorin or pharmaceutically acceptable salts of albiflorin to preparation of human melatonin system function improving products. Albiflorin or the pharmaceutically acceptable salts of albiflorin serving as an endogenous melatonin secretion accelerant and a melatonin receptor stimulant can be used for preparing drugs, food, health care products, food additives or nutritional supplements for improving and treating sub-health statuses and / or diseases caused by melatonin system dysfunction, wherein the sub-health statuses are selected from one or more of biological rhythm disorder type sleep disorder, senile sleep disorder, affective disorder, cognitive disorder and immune system dysfunction; the diseases are selected from one or more of depression, anxiety disorder, Alzheimer's disease and Parkinson's disease.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the use of paeoniflorin (Albiflorin), more specifically to the use of paeoniflorin in the preparation of products for improving the function of the melatonin system, especially its use in the preparation of products for prevention and / or treatment Use in drugs, food, health products, food additives or nutritional supplements for sub-health states and / or diseases caused by melatonin system dysfunction. Background technique [0002] Melatonin (N-acetyl-5-methoxytryptamine) is a hormone mainly synthesized and secreted by the pineal gland, mainly through tryptophan and S-adenosylmethionine. Melatonin can regulate the circadian rhythm and reproductive function of mammals, and it belongs to the lipophilic hormone widely distributed in the nervous system, blood and surrounding tissues of mammals. Melatonin exerts its biological effects by interacting with specific melatonin receptors. When melat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/20A61P25/22A61P25/24A61P25/28A61P25/16A61P37/02A23L33/105A23L33/125
CPCA23L33/105A23L33/125A61K31/7048A23V2002/00A23V2200/324A23V2200/322A23V2200/30
Inventor 张作光
Owner 张作光
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