Preparation method of N-phenyl-N-[8]quinolyl-4-fluoro-benzamide
A benzamide and quinoline-based technology, which is applied in the field of preparation of N-phenyl-N-[8]quinolyl-4-fluoro-benzamide, can solve the problem of high price, high catalyst toxicity, organic phosphorus Ligand dependence and other issues, to achieve the effect of mild reaction conditions, environmental friendliness, and high economy
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[0008] In the present invention, 4-fluoro-benzoyl 8-aminoquinoline, anhydrous copper acetate, triphenylbismuth, sodium bicarbonate, 1,4-dioxane solvent and No. 5 magneton are successively added to the reactor. One, the condensate pipe is passed through the condensed water from the bottom to the top, and the reactor is placed in an oil bath to heat the reaction. After the reaction, the reaction solution was poured into a separatory funnel, distilled water was added, and extracted three times with L ethyl acetate. The obtained organic phases were combined and spin-dried by a rotary evaporator, and the crude product was separated and purified by column chromatography to obtain N-phenyl-N-[8]quinolyl-4-fluoro-benzamide.
[0009] The purity of described 4-fluoro-benzoyl-8-aminoquinoline is 98%, the purity of triphenyl bismuth is 98%, the purity of anhydrous copper acetate is 99%, the purity of sodium bicarbonate is 99.5%, 1 , The purity of 4-dioxane is 99.5%.
[0010] The reactor...
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