Zinc coordination polymer catalyst for preparing polyglycolic acid and preparation method of zinc coordination polymer catalyst

Abstract

The invention relates to a zinc coordination polymer catalyst for preparing polyglycolic acid and a preparation method of the zinc coordination polymer catalyst and relates to the field of polyglycolic acid catalysts. A chemical formula of the zinc coordination polymer catalyst is [Zn(BDC)L], wherein BDC in the formula is a terephthalate anion, and L is a 2,3,5,6-tetrachloro-N,N'-bis(4-pyridine) diamide ligand. According to the preparation method disclosed by the invention, zinc nitrate hexahydrate and terephthalic acid and 2,3,5,6-tetrachloro-N,N'-bis(4-pyridine) diamide as organic ligands undergo thermal reaction in N,N-dimethylformamide under the closed conditions to obtain a zinc coordination polymer containing a quadruple interpenetrating diamond three-dimensional net structure. The synthesis method disclosed by the invention has the advantages of high yield and good reproducibility; the obtained crystal has high purity; the zinc coordination polymer has good catalytic activity for catalyzing glycolide ring-opening polymerization; the weight-average molecular weight of the prepared polypolyglycolic acid is greater than 0.06 million; the polypolyglycolic acid can be applied to the field of biomedical polymer materials.

Description

technical field [0001] The invention relates to the field of polyglycolic acid catalysts, in particular to a zinc coordination polymer, a preparation method thereof and an application for catalyzing the ring-opening polymerization of glycolide bulk. Background technique [0002] Polyglycolic acid, also known as polyglycolic acid, or PGA for short, is a linear aliphatic polyester with the simplest structure, and it is also the first medical synthetic polymer material approved by the US FDA as an absorbable surgical suture (commodity Named Dexon @ ). Due to its good biocompatibility, non-toxicity and adjustable degradation, PGA has great potential in medical absorbable surgical sutures, drug sustained / controlled release carrier materials, simulated human tissue materials, and biodegradable polymer scaffold materials. Broad application prospects (Middleton J.C., Tipton A.J. Biomaterials 2000, 21, 2335–2346). [0003] PGA can be synthesized mainly by direct polycondensation a...

AI Technical Summary

Problems solved by technology

However, tin compounds have certain cytotoxicity, and the molecular weight distribution is very wide in the process of catalyzing the ring-opening polymerization of glycolide, which is not conducive to the application of polyglycolic acid in the field of medical polymer materials.

Studies have found that main group metals such as aluminum, calcium, magnesium, and bismuth, transition metals such as zinc, titanium, and zirconium, and lanthanide metal complexes also have the ability to catalyze ring-opening polymerization of lactones (Dechy-Cabaret O., Martin-Vaca B .,Bourissou D.Chem.Rev.2004,104,6147–6176; Labet M,Thielemans W.Chem.Soc.Rev.2009,38,3484–3504), but these catalyst systems are difficult to balance low toxicity and high activity , high molecular weight and narrow distribution

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