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Preparation method of nano-composite hydrogel

A nanocomposite and hydrogel technology, which is applied in the field of nanocomposite hydrogel preparation, can solve the problems of toxicity and high consumption, and achieve the effects of good biocompatibility, high mechanical properties and rich sources of raw materials

Active Publication Date: 2017-12-12
QINGDAO AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, a variety of cross-linking agents (glutaraldehyde, transglutaminase, and geni etc.) are applied to gelatin hydrogels by cross-linking methods in order to enhance the mechanical properties of gelatin hydrogels, but these cross-linking The combination has potential toxicity and high consumption problems

Method used

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  • Preparation method of nano-composite hydrogel
  • Preparation method of nano-composite hydrogel
  • Preparation method of nano-composite hydrogel

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preparation example Construction

[0028] The invention provides a kind of preparation method of nanocomposite hydrogel, comprises the following steps:

[0029] 1) Acid hydrolyzing chitin with a degree of acetylation of 0.94 to obtain a dispersion of chitin nano-whisker reinforcing agent;

[0030] 2) Mixing the chitin nano-whisker reinforcing agent dispersion liquid with the gelatin solution, and cooling to obtain a nano-composite hydrogel.

[0031] In the invention, the chitin with an acetylation degree of 0.94 is subjected to acid hydrolysis to obtain the chitin nano-whisker reinforcing agent. In the present invention, the step 1) acid hydrolysis adopts hydrochloric acid solution or sulfuric acid solution. When choosing hydrochloric acid solution to carry out acidolysis, the mass of described chitin and the volume ratio of hydrochloric acid solution are 1g:30mL, and the molar concentration of described hydrochloric acid solution is preferably 3mol / L; When adopting sulfuric acid solution to carry out acidolys...

Embodiment 1

[0036] 1. Chitin nano-whisker enhancer dispersion liquid: mix chitin with a degree of acetylation of 0.94 and hydrochloric acid at 1g:30mL, acidolysis temperature is 95°C, time is 10h, and the chitin nano-whisker enhancer is obtained by acidolysis Dispersions. Dialysis, centrifugal washing and drying were performed after the acid hydrolysis process.

[0037] 2. Nano-composite hydrogel: prepare different concentrations of chitin nano-whisker enhancer dispersion liquid, add it to 14% gelatin solution (45°C), mix the two evenly, and finally nano-chitin accounts for 0.25% of the entire solution , 0.5% and 1.0%, and then the mixed solution was cooled at 4° C. for 12 hours to obtain a nanocomposite hydrogel. In addition, in order to study the influence of pH and ion concentration on the composite hydrogel, 1M NaOH or HCl is used to adjust the pH value to 3.0, 4.0, 5.0, 7.0, 8.0 or 9.0, and NaCl is used to adjust the ion concentration to 10, 30, 50, 70, 90mM.

Embodiment 2

[0039] Determination of gelation temperature and viscoelasticity: The dynamic rheological measurement of the nanocomposite hydrogel is measured using a strain-controllable rheometer, setting parameters: the temperature is 25°C, the rotor diameter and the parallel plate gap are 50mm and 1mm respectively , the frequency sweep is the angular frequency range 0.1-100rad / s, the constant strain is 1% (in the linear viscoelastic region), and the storage modulus (G') and loss modulus (G") are recorded. In order to observe the maturation of the gel sample The time sweep was determined, and the scan was performed at 10°C for 2.5h. The temperature sweep was decreased from 40°C to 10°C, and then increased to 40°C at a rate of 1°C per minute.

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Abstract

The invention relates to a preparation method of nano-composite hydrogel, belonging to the technical field of hydrogel preparation. The preparation method of the nano-composite hydrogel comprises the following steps: (1) carrying out acidolysis on chitin with acetylation degree of 0.94 to obtain chitin nano-whisker reinforcing agent dispersion; (2) mixing the chitin nano-whisker reinforcing agent dispersion with a gelatin solution, and cooling to obtain the nano-composite hydrogel. The nano-composite hydrogel prepared by the method is good in mechanical properties and high in gelatinization temperature, and has very good stability in the environment with strong acidity and high salt ion concentration, thus being wide applied to the fields of food, cosmetics and medicines.

Description

technical field [0001] The invention relates to the technical field of hydrogel preparation, in particular to a preparation method of nanocomposite hydrogel. Background technique [0002] Hydrogel is a three-dimensional polymeric network that can absorb and maintain a large amount of water, and is widely used in food, cosmetics, biomedicine, as well as bone tissue and drug loading. Hydrogels need to have high strength and flexibility when applied, as well as reversible deformation properties. However, ordinary chemically cross-linked polymer hydrogels are brittle and break easily under certain pressure. Crosslinked hydrogels, double network hydrogels and nanocomposite hydrogels are all common hydrogels. Prior art studies have been conducted on enhancing the mechanical properties of the above-mentioned hydrogels. Among them, studies have demonstrated that double-network hydrogels can enhance the mechanical properties of gels, but most of these polymer hydrogels require the...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J5/00C08L89/00C08L5/08
CPCC08J3/075C08J5/005C08J2389/00C08J2405/08C08L89/00C08L2205/06C08L2205/16C08L5/08
Inventor 孙庆杰熊柳葛胜菊卢浩李曼赵梅
Owner QINGDAO AGRI UNIV
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