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Preparation method for multifunctional nano-composite hydrogel

A nanocomposite, hydrogel technology, applied in the field of nanomaterials, can solve problems such as being difficult to be widely used

Active Publication Date: 2017-12-22
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods have been difficult to be widely used due to the strict control of the selection of crosslinkers and initiators and the polymerization conditions in the preparation conditions.

Method used

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  • Preparation method for multifunctional nano-composite hydrogel
  • Preparation method for multifunctional nano-composite hydrogel
  • Preparation method for multifunctional nano-composite hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: Preparation of metal nanomaterial dispersion liquid

[0033] 1. Add 0.6mL of 0.02M chloroauric acid and 48.4mL of deionized water into a 100ml round-necked flask, place it in an oil bath at 100°C and stir for 10min to make it evenly mixed, then add 1mL with a mass fraction of 1% The sodium citrate solution was stirred at 100° C. for 5 minutes, and cooled to room temperature after the reaction was complete, to obtain a metal nanomaterial dispersion with a particle shape.

[0034] 2. Add 0.3mL of 0.2M chloroauric acid and 44.7mL of deionized water into a 100ml round-necked flask, place it in an oil bath at 100°C and stir for 10min to make it evenly mixed, then add 5mL with a mass fraction of 1% The sodium citrate solution was stirred at 100° C. for 5 minutes, and cooled to room temperature after the reaction was complete, to obtain a metal nanomaterial dispersion with a particle shape.

[0035] 3. Add 0.6mL of 0.2M chloroauric acid and 48.4mL of deionized w...

Embodiment 2

[0037] 1. Surface modification of metal nanomaterials

[0038] Mix the 0.047mol / L metal nanomaterial dispersion with particle shape prepared in step 1 of Example 1 with the functional modifier 2-methyl-4'-(methylthio)-2-morpholino propiophenone respectively The mass of the functional modifier added is 0.02%, 0.04%, and 0.1% of the mass of the metal nanomaterial dispersion, and ultrasonication is carried out at room temperature for 15s to obtain a surface-modified metal nanomaterial dispersion;

[0039] 2. Preparation of hydrogel

[0040] Under the protection of nitrogen, the hydrophilic monomer acrylamide is added to the surface-modified metal nanomaterial dispersion obtained in step 1, ultrasonically dissolved for 30 s, and placed in a vacuum drying oven to stand still to remove dissolved oxygen in the solution; Then place it in an ultraviolet light box for 20 minutes of polymerization reaction, and cool to room temperature to obtain a nanocomposite hydrogel.

[0041] The add...

Embodiment 3

[0044] 1. Surface modification of metal nanomaterials

[0045] The 0.094mol / L metal nanomaterial dispersion with particle shape prepared in step 2 of Example 1 was mixed with the functional modifier 2-methyl-4'-(methylthio)-2-morpholinopropiophenone The mass of the functional modifier added is 0.02%, 0.04%, and 0.1% of the mass of the metal nanomaterial dispersion, and ultrasonication is carried out at room temperature for 15s to obtain a surface-modified metal nanomaterial dispersion;

[0046] 2. Preparation of hydrogel

[0047] Under the protection of nitrogen, the hydrophilic monomer acrylamide is added to the surface-modified metal nanomaterial dispersion obtained in step 1, ultrasonically dissolved for 30 s, and placed in a vacuum drying oven to stand still to remove dissolved oxygen in the solution; Then place it in an ultraviolet light box for 20 minutes of polymerization reaction, and cool to room temperature to obtain a nanocomposite hydrogel.

[0048] The added mas...

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Abstract

The invention discloses a preparation method for a multifunctional nano-composite hydrogel. The method comprises the following steps: firstly, compounding a radical initiator and a metal nanometer material in the manner of dynamic covalent bond, thereby acquiring a nano composite, and then triggering local quick free radical polymerization reaction of the nano composite under the existence of polymerizable monomer, thereby acquiring the nano-composite hydrogel. Compared with the traditional hydrogel, the network structure of the multifunctional nano-composite hydrogel disclosed by the invention has certain discontinuity, so that the multifunctional nano composite hydrogel can be degraded in an aqueous solution under a swelling effect; due to the discontinuous structure, the hydrogel is soft and can be injected by a syringe needle of a 26G injector; besides, the reversible coordination between the functional nanometer material and the radical initiator is utilized to dynamically bond and disconnect the coordinate bond between the metal and sulfur under the irradiation of infrared ray, so that the broken hydrogel can achieve the self-healing purpose.

Description

technical field [0001] The invention relates to a preparation method of a multifunctional nanocomposite hydrogel, belonging to the technical field of nanomaterials. Background technique [0002] Hydrogel is a soft material with a three-dimensional network structure formed by cross-linking water-soluble polymer chains through covalent or non-covalent bonds and containing a large amount of water. Because the softness of hydrogel is very similar to biological tissue, it has a wide range of applications in tissue engineering. Due to its fragmented and fragile network structure, traditional hydrogels have poor mechanical properties and lack the potential for biological applications. In 2002, Japanese scientist T. Takehisa first proposed the concept of nanocomposite hydrogels. In the process of hydrogel synthesis, clay sheet nanomaterials were used as crosslinking agents to form hydrogels. This new type of hydrogel prepared by introducing nanomaterials into the hydrogel network ...

Claims

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Application Information

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IPC IPC(8): C08F20/56C08F2/48C08F2/44C08K9/04C08K3/08C08J3/075
CPCC08F2/44C08F2/48C08F20/56C08J3/075C08J2333/26C08K3/08C08K9/04C08K2003/0806C08K2003/0831C08K2201/011
Inventor 秦海利燕宇从怀萍刘萍陈传瑞
Owner HEFEI UNIV OF TECH
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