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Polyether sulfone hollow fiber dialysis membrane and preparation method thereof

A hollow fiber and dialysis membrane technology, applied in dialysis systems, semi-permeable membrane separation, chemical instruments and methods, etc., to achieve high production efficiency, high mechanical strength, and improved clearance rate

Inactive Publication Date: 2017-12-26
李亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the existing dialysis membrane can only remove metabolic waste in the blood by means of diffusion and convection. If the dialysis membrane can also be given the function of removing some metabolic waste through adsorption, the removal rate of metabolic waste will be greatly improved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] (1) According to the following components and weight percentages, it is used as the raw material of the casting solution and dissolved evenly in the stirring tank, the stirring temperature is 70°C, and the casting solution is obtained by standing for defoaming, and the temperature of the casting solution is 50°C.

[0047] Components: 15% polyethersulfone resin, 3% diatomaceous earth, 4% amphiphilic copolymer (preferably polyether-modified silicone oil in this embodiment), organic porogen (preferably polyethylene Diol) 8%, biocompatible polymer (preferably polyvinylpyrrolidone in this example) 4%, solvent (dimethylacetamide in this example) 66%.

[0048] (2) Hollow fiber dialysis membranes were spun by conventional dry-wet spinning process. After passing through the filter screen, the casting liquid is extruded from the spinneret together with the core liquid, and after walking 10cm in the air, it is shaped in a coagulation bath, cleaned in a cleaning bath, dried in a dr...

Embodiment 2

[0051] (1) According to the following components and weight percentages, it is used as the raw material of the casting solution and dissolved evenly in the stirring tank, the stirring temperature is 70°C, and the casting solution is obtained by standing for defoaming, and the temperature of the casting solution is 50°C.

[0052] Components: 16% polyethersulfone resin, 2% diatomaceous earth, 3% amphiphilic copolymer (preferably polymethylmethacrylate-polystyrene in this example), organic porogen (in this example Among them, it is preferably: polyethylene glycol 5%+glycerol 3%) 8%, a polymer with good biocompatibility (preferably polyvinylpyrrolidone in this embodiment) 4%, solvent (preferably polyvinylpyrrolidone in this embodiment) Dimethylacetamide) 67%.

[0053] (2) Hollow fiber dialysis membranes were spun by conventional dry-wet spinning process. After passing through the filter screen, the casting liquid is extruded from the spinneret together with the core liquid, and a...

Embodiment 3

[0056] (1) According to the following components and weight percentages, it is used as the raw material of the casting solution and dissolved evenly in the stirring tank, the stirring temperature is 75°C, and the casting solution is obtained by standing for defoaming, and the temperature of the casting solution is 55°C.

[0057] Components: 18% polyethersulfone resin, 2% diatomaceous earth, 2% amphiphilic copolymer (preferably polyether-modified silicone oil in this embodiment), organic porogen (preferably polyethylene Diol) 10%, polymer with good biocompatibility (preferably polymethyl methacrylate in this embodiment) 3%, solvent (preferably dimethyl sulfoxide in this embodiment) 65%.

[0058] (2) Hollow fiber dialysis membranes were spun by conventional dry-wet spinning process. After passing through the filter screen, the casting liquid is extruded from the spinneret together with the core liquid, and after walking 30cm in the air, it is shaped in a coagulation bath, cleane...

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PUM

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Abstract

The invention relates to a polyether sulfone hollow fiber dialysis membrane and a preparation method thereof, belonging to the technical field of hollow fiber membranes separated through a common physical or chemical method by taking the shape, structure or performance as the characteristic. The membrane casting liquid of the polyether sulfone hollow fiber dialysis membrane is mainly composed of polyether sulfone resin, diatomite, an amphiphilic copolymer, an organic pore-foaming agent, a polymer with good biocompatibility and a solvent. The polyether sulfone hollow fiber dialysis membrane is applied to the fields of hematodialysis and the like and has the advantages of high mechanical strength, good biocompatibility, permanent hydrophily, high ultrafiltration coefficient and clearing rate and the like.

Description

technical field [0001] The invention relates to a polyethersulfone hollow fiber dialysis membrane and a preparation method thereof, belonging to the technical field of hollow fiber membranes characterized by shape, structure or performance and separated by general physical or chemical methods. Background technique [0002] Hemodialysis has been developed for more than 90 years, and hemodialysis is one of the alternative treatments for patients with acute and chronic renal failure. It drains the blood from the body to the outside, passes through the dialysis membrane in the hemodialysis machine to remove metabolic waste, impurities and water in the blood, and then sends the purified blood back to the body. The dialysis membrane is composed of countless hollow fibers. When the blood flows through the inside of these hollow fibers, it exchanges substances with the electrolyte solution located on the outside of the hollow fibers that is similar to the concentration of the body t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D69/08B01D69/02B01D67/00A61M1/16
CPCB01D71/68A61M1/1621B01D67/0013B01D69/02B01D69/08B01D2325/36
Inventor 李亮
Owner 李亮
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