Liquid adhesive bandage and preparation method thereof

A liquid wound dressing and filtrate technology, applied in the medical field, can solve the problems such as the inability to exert the normal film-forming protection function, the poor film-forming performance of the liquid wound dressing, and the limitation of the effectiveness of drug components, so as to improve the drug release performance and facilitate wound healing. , the effect of inhibiting wound infection

Inactive Publication Date: 2017-12-29
GUANGXI XINYE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are several core problems in liquid bandages: first, the film-forming performance of liquid bandages is poor, or the formed film is not tough enough, easy to break, cannot play the normal film-forming protective function, and even affects drug performance; Second, the effectiveness of drug components is limited, as well as the synergy with the membrane
The setting of membrane components, on the one hand, needs to have good biocompatibility, degradability and good release performance for drug ingredients; the drug ingredients need to be effective, and together with the membrane components, have good Release performance, in order to facilitate the treatment of wounds; third, the use of organic solvents such as ethanol, which is more irritating to the wound, or potentially other organic residual toxicity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A liquid wound patch is prepared from the following parts by weight:

[0038] Superoxide dismutase 0.01g, polyvinyl alcohol 0.2g, povidone 0.2g, comfrey extract 0.1g, forsythia extract 0.1g, glycerol 0.5g, water 80g.

[0039] A method for preparing a liquid wound patch includes the following steps:

[0040] (1) Preparation of comfrey extract: Take comfrey material, pulverize it into coarse powder, add water twice the weight of the medicinal material, and extract 2 times by ultrasonic heating, each 1h, combine the extracts, filter, and filter the filtrate at 50°C The following is concentrated under reduced pressure to an extract with a relative density of 1.10 at room temperature, let cool, add 3 times the amount of ethanol, stir, let stand for 2 hours, precipitate, filter, and recover ethanol from the filtrate under reduced pressure to obtain a comfrey extract;

[0041] (2) Preparation of Forsythia suspensa extract: take the Forsythia suspensa medicinal material, pulverize it i...

Embodiment 2

[0044] A liquid wound patch is prepared from the following raw materials by weight:

[0045] Superoxide dismutase 0.5g, polyvinyl alcohol 5g, povidone 5g, comfrey extract 3g, forsythia extract 3g, glycerin 8g, water 100g.

[0046] A method for preparing a liquid wound patch includes the following steps:

[0047] (1) Preparation of Lithospermum erythrorhizon extract: take comfrey material, pulverize it into coarse powder, add water 4 times the weight of the medicinal material, extract 3 times by ultrasonic heating, 2h each time, combine the extracts, filter, and filter the filtrate at 70°C The following is concentrated under reduced pressure to an extract with a relative density of 1.20 at room temperature, let cool, add 5 times the amount of ethanol, stir, let stand for 3 hours, precipitate, filter, the filtrate is decompressed to recover ethanol to obtain a comfrey extract;

[0048] (2) Preparation of Forsythia suspensa extract: take the Forsythia suspensa medicinal material, pulveri...

Embodiment 3

[0051] A liquid wound patch is prepared from the following raw materials by weight:

[0052] Superoxide dismutase 0.01g, polyvinyl alcohol 0.5g, povidone 0.5g, comfrey extract 0.1g, forsythia extract 0.1g, glycerol 1g, water 85g.

[0053] A method for preparing a liquid wound patch includes the following steps:

[0054] (1) Preparation of comfrey extract: take comfrey material, pulverize it into coarse powder, add water 3 times the weight of the medicinal material, and extract 2 times by ultrasonic heating, 1.5h each time, combine the extracts, filter, and filter the filtrate at 55 Concentrate under reduced pressure below ℃ to an extract with a relative density of 1.10 at room temperature, let it cool, add 4 times the amount of ethanol, stir, let stand for 2h, precipitate, filter, and recover ethanol from the filtrate under reduced pressure to obtain a comfrey extract;

[0055] (2) Preparation of Forsythia suspensa extract: Take the forsythia suspensa medicinal material, pulverize it ...

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PUM

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Abstract

The invention relates to a liquid adhesive bandage and a preparation method thereof. The liquid adhesive bandage is prepared from superoxide dismutase, polyvinyl alcohol, povidone, traditional Chinese medicine extract and glycerin. The liquid adhesive bandage is high in film forming performance, stable in treatment effect and free of irritation to wounds.

Description

Technical field [0001] The invention relates to the field of medical technology, in particular to a liquid wound patch and a preparation method thereof. Background technique [0002] Band-aid is the most commonly used surgical drug in people's lives. Band-aids can stop bleeding and protect creation. The traditional wound tape is generally a long strip of tape with a drug layer in the middle, which is generally used for emergency treatment of small wounds, so as to temporarily stop bleeding and protect the wound. The traditional bandage is an adhesive bandage. The adhesive bandage is not tightly attached to the wound. It has no effect on concave wounds and has poor air permeability. It is easy to be infected by bacteria in the summer and humid environment and cause suppuration. Moreover, the adhesive cloth wound The effective wound area of ​​the patch is superficial and the range is limited. The shape and area of ​​the wound are limited, and the wound healing speed is slow. For ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/10A61K38/44A61P17/02A61L26/00A61K36/634
CPCA61K9/7015A61K36/30A61K36/634A61K38/446A61K47/10A61K47/32A61L26/0014A61L26/0066A61L2300/254A61L2300/30A61L2300/404A61L2300/45C12Y115/01001A61K2300/00C08L29/04C08L39/06
Inventor 梁文棋
Owner GUANGXI XINYE BIOLOGICAL TECH
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