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Biological tissue-reinforcing material

A technology for reinforcing materials and biological tissues, which is used in textiles and papermaking, medical science, absorbent pads, etc., and can solve problems such as virus infection

Active Publication Date: 2018-01-02
GUNZE LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, fibrin glue as a blood product may cause unknown viral infections

Method used

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  • Biological tissue-reinforcing material
  • Biological tissue-reinforcing material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] (1) Preparation of fiber structure made of hydroxyethylated cellulose

[0065] A 280-μm-thick single-knit fabric made of No. 80 cellulose yarn as a raw material was bleached by hydrogen peroxide bleaching.

[0066] Then, 3.55 g of the bleached knitted fabric was immersed in 140 mL of 10% aqueous sodium hydroxide solution at 15° C. for 30 minutes to alkalize the cellulose. The alkalized knitted fabric was trodden flat by applying a load of 2.5 to 3.0 kg.

[0067] Next, 12.25 g of the obtained knitted fabric made of alkaline cellulose was immersed in 50 mL of a 0.8 mol / L ethylene oxide hexane solution at 25° C., and then reacted at 50° C. for 3 hours. The reacted knitted fabric was washed by immersing 70 mL of a mixture of methanol and methyl isobutyl ketone (methanol:methyl isobutyl ketone = 35:35) at 25°C for 5 minutes, and then washed by immersing 72.6 mL at 25°C Neutralize in a mixture of methanol, methyl isobutyl ketone and acetic acid (methanol: methyl isobutyl ke...

Embodiment 2

[0079] The prepared biological tissue reinforcement material was obtained in the same manner as in Example 1, except that the 200-μm-thick single-knit fabric made of 160-gauge cellulose yarn was used as a raw material to prepare the hydroxyethylated fiber fiber structure made of cellulose, and a combination of the three fiber structures made of hydroxyethylated cellulose / nonwoven made of polyglycolide / made of hydroxyethylated cellulose in the prescribed order The combination of the two fiber structures is laminated. Stress testing of biological tissue reinforcement materials. In the pressure test, the obtained test sample is placed in the center of the collagen membrane placed in the filter holder, so that the surface of the combined side of the three fibrous structures made of hydroxyethylated cellulose and the collagen membrane touch.

[0080] Table 1 shows the results of the stress test.

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Abstract

Provided is a biological tissue-reinforcing material capable of more reliably reinforcing weakened tissue while preventing air leakage and fluid leakage without using fibrin glue, which is a blood product. Provided is a biological tissue-reinforcing material comprising a laminated structure, the laminated structure comprising: a fiber structure made of a bioabsorbable polymer; and a fiber structure made of etherified cellulose that is produced through etherification of hydroxyl groups of cellulose.

Description

technical field [0001] The present invention relates to a biological tissue reinforcement material capable of more reliably reinforcing weakened tissues while preventing air leakage or liquid leakage without using fibrin glue as a blood product. Background technique [0002] The most fundamental problem in the field of surgery is the repair of damaged or weakened organs or tissues. For example, bleeding from a damaged organ is still treated by stopping the bleeding and suturing the wound, and even now this is the most common surgical procedure for hemostasis. Furthermore, another important issue in surgical treatment is preventing leakage of fluid or air from weakened or damaged tissues. Especially in the field of thoracic surgery, it is important to prevent air leakage caused by pneumothorax or after resection of lung cancer. In particular, pneumothorax is a difficult disease to treat because of the increased recurrence rate without appropriate treatment. [0003] Pneumo...

Claims

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Application Information

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IPC IPC(8): A61F13/53A61F13/511D21H27/38
CPCA61L27/16A61L31/048C08L1/00
Inventor 田中千晶由井美也木南启司松田晶二郎
Owner GUNZE LTD
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