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Bone repair material having tissue oxygenation function and application of bone repair material

A bone repair and function technology, applied in additive processing, medical science, prosthesis, etc., can solve the problems of lack of oxygen supply, affecting the speed of wound healing, etc., to achieve high safety, increase recovery speed and success rate, speed up the effect of speed

Active Publication Date: 2018-01-12
上海禾澜纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, whether it is 3D printed bone tissue scaffolds, filling particles, or injectable bone cement, there is a problem of tissue oxygen supply after implantation, especially for larger scaffolds and fillers, which lack oxygen after going deep into the tissue Before the tissue restores blood supply, cell growth is affected to varying degrees, thus affecting the speed of wound healing

Method used

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  • Bone repair material having tissue oxygenation function and application of bone repair material
  • Bone repair material having tissue oxygenation function and application of bone repair material

Examples

Experimental program
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Effect test

Embodiment 1

[0031] 1. Preparation of gelatin-modified α-TCP

[0032] (1) Mix calcium hydrogen phosphate and calcium carbonate in a molar ratio of 2:1. The mixing method is ultrapure water, 400rpm ball milling and mixing under the ball milling medium, the mixing time is 2-4h, and the mixed suspension is dried in an oven at 130°C.

[0033] (2) The above-mentioned dried raw materials are calcined in a muffle furnace at 1250-1400°C for 2-4 hours at high temperature, taken out and rapidly cooled in a blast environment to obtain α-TCP powder. The product was ball-milled with absolute ethanol as the ball-milling medium at 450 rpm for 2-4 hours, and the suspension after ball-milling was used to remove ethanol by a rotary evaporator, and dried in an oven at 60°C.

[0034] (3) Prepare an aqueous gelatin solution with a mass fraction of 0.05-0.5%. The preparation method is stirring and dissolving under heating at 50° C., and the stirring method is magnetic stirring or mechanical stirring. Mix the...

Embodiment 2

[0041] 1. Preparation of gelatin-modified α-TCP

[0042] (1) Mix calcium hydrogen phosphate and calcium carbonate in a molar ratio of 2:1. The mixing method is ultrapure water, 400rpm ball milling and mixing under the ball milling medium, the mixing time is 2-4h, and the mixed suspension is dried in an oven at 130°C.

[0043](2) The above-mentioned dried raw materials are calcined in a muffle furnace at 1250-1400°C for 2-4 hours at high temperature, taken out and rapidly cooled in a blast environment to obtain α-TCP powder. The product was ball-milled with absolute ethanol as the ball-milling medium at 450 rpm for 2-4 hours, and the suspension after ball-milling was used to remove ethanol by a rotary evaporator, and dried in an oven at 60°C.

[0044] (3) Prepare an aqueous gelatin solution with a mass fraction of 0.05-0.5%. The preparation method is stirring and dissolving under heating at 50° C., and the stirring method is magnetic stirring or mechanical stirring. Mix the ...

Embodiment 3

[0050] 1. Preparation of gelatin-modified α-TCP

[0051] (1) Mix calcium hydrogen phosphate and calcium carbonate in a molar ratio of 2:1. The mixing method is ultrapure water, 400rpm ball milling and mixing under the ball milling medium, the mixing time is 2-4h, and the mixed suspension is dried in an oven at 130°C.

[0052] (2) The above-mentioned dried raw materials are calcined in a muffle furnace at 1250-1400°C for 2-4 hours at high temperature, taken out and rapidly cooled in a blast environment to obtain α-TCP powder. The product was ball-milled with absolute ethanol as the ball-milling medium at 450 rpm for 2-4 hours, and the suspension after ball-milling was used to remove ethanol by a rotary evaporator, and dried in an oven at 60°C.

[0053] (3) Prepare an aqueous gelatin solution with a mass fraction of 0.05-0.5%. The preparation method is stirring and dissolving under heating at 50° C., and the stirring method is magnetic stirring or mechanical stirring. Mix the...

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Abstract

The invention relates to a bone repair material having a tissue oxygenation function and an application of the bone repair material. The bone repair material is prepared from gelatin-modified [alpha]-TCP and PLGA-coated PFOB microparticle sol according to a proportion of 2.5-3.4g / ml. By adding perfluoro-octyl bromothane (PFOB) particles, which serve as an oxygenation agent, to the gelatin-modified[alpha]-tertiary calcium phosphate ([alpha]-TCP), the tissue oxygenation function is achieved, so that the problem on cell oxygen supply before the recovery of blood supply after tissue injury occursis solved, and high safety is guaranteed. The invention also provides the application of the repair material; the prepared artificial bone scaffold and bone cement bone repair material has the oxygenation function, so that the problem that blood supply is in lack in the initial stage of the transplantation of an artificial bone scaffold or bone cement is solved; and necessary oxygen is provided for cell proliferation, so that a tissue healing speed is accelerated; the bone repair material is simple in preparation method and meets the requirements of clinical application; and the bone repair material has a broad application prospect.

Description

technical field [0001] The present invention relates to a bone repair material with tissue oxygenation function, in particular to a bone repair material with tissue oxygenation function and its application, gelatin modified α-tricalcium phosphate (α-TCP) with oxygen enhancer Perfluoro-n-octyl bromide (PFOB) particles can achieve the function of tissue oxygenation, and solve the problem of cell oxygen supply before restoring blood supply after tissue trauma. The method belongs to the field of biomedical materials, and the prepared materials can be widely used in the repair of bone tissue. Background technique [0002] Fractures and bone defects caused by trauma, tumor, infection, congenital defects, osteoporosis and other reasons have always been one of the clinical problems. , easy to cause secondary trauma and other reasons, the use of bone substitute materials is an inevitable means. Currently used bone substitute materials mainly include metal materials, polymer materia...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/18A61L27/22B33Y70/00
Inventor 何丹农王萍杨迪诚朱君王杰严一楠金彩虹
Owner 上海禾澜纳米科技有限公司
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