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Preparation method and application of atropa belladonna extract

A technology of belladonna extract and belladonna, applied in the field of medicine, can solve the problems of incomplete extraction of alkaloids, large amount of ethanol, complicated process, etc., achieve the effects of shortening the preparation time, improving the extraction effect, and simplifying the preparation process

Inactive Publication Date: 2018-01-16
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Above-mentioned each method, process is complicated, and the alkaloid extraction that belladonna contains is incomplete, takes a long time, and ethanol consumption is big

Method used

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  • Preparation method and application of atropa belladonna extract
  • Preparation method and application of atropa belladonna extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation method of embodiment 1 belladonna extract

[0024] Step 1. Soaking in warm water: wash and dry the belladonna, grind it into powder, pass through a 60-mesh sieve, add 100 g of belladonna powder and heat it to 30°C, stir for 2 hours, and then let it stand for 2 hours; filter to obtain filtrate A and filter residue B;

[0025] Step 2, alcohol extraction: add an ethanol solution 10-15 times the weight of the filter residue B to the filter residue B and soak for 2 hours;

[0026] Step 3, percolation: placing the mixed solution in step 2 in the percolation cylinder for slow percolation, collecting filtrate C, mixing filtrate A and filtrate C, and concentrating under reduced pressure to obtain belladonna extract.

[0027] In this example, when the percolation time was 20 h, the extraction rate of the belladonna extract alkaloids was 71%. Wherein the extraction rate is the percentage of the target substance (alkaloid) extracted from the original drug per unit ...

Embodiment 2

[0028] The preparation method of embodiment 2 belladonna extract

[0029] Step 1. Soaking in warm water: wash and dry the belladonna, grind it into powder, pass through a 60-mesh sieve, add 100 g of belladonna powder and heat it to 30°C, stir for 2 hours, and then let it stand for 2 hours; filter to obtain filtrate A and filter residue B;

[0030] Step 2, alcohol extraction: add an ethanol solution 10-15 times the weight of the filter residue B to the filter residue B and soak for 2 hours;

[0031] Step 3, percolation: first cover the multi-layer cellulase membrane in the percolation cylinder, then place the mixed solution in step two in the percolation cylinder for slow percolation, collect filtrate C, and mix filtrate A and filtrate C After mixing, they were concentrated under reduced pressure to obtain belladonna extract.

[0032] Wherein the cellulase membrane is prepared by the following process: 5 g of cellulose acetate is dissolved in 100 mL of acetone, and after being...

Embodiment 3

[0034] The preparation method of embodiment 3 belladonna extract

[0035] Step 1. Soaking in warm water: wash and dry the belladonna, grind it into powder, pass through a 60-mesh sieve, add 100 g of belladonna powder and heat it to 30°C, stir for 2 hours, and then let it stand for 2 hours; filter to obtain filtrate A and filter residue B;

[0036] Step 2, alcohol extraction: add an ethanol solution 10-15 times the weight of the filter residue B to the filter residue B and soak for 2 hours;

[0037] Step 3, percolation: first cover the multi-layer cellulase membrane in the percolation cylinder, then place the mixed solution in step two in the percolation cylinder for slow percolation, collect filtrate C, and mix filtrate A and filtrate C After mixing, they were concentrated under reduced pressure to obtain belladonna extract. Specifically, the percolation cylinder is placed in an ultrasonic transmitter, and the ultrasonic intensity is set to about 50KHz.

[0038] Wherein the ...

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Abstract

The invention discloses a preparation method and an application of an atropa belladonna extract. The preparation method comprises processes as follows: soaking in warm water, ethanol extraction, percolation and the like. According to the medicine preparation method, the inside of a percolator is covered with multiple layers of cellulase membranes, cell walls consisting of cellulose in atropa belladonna are broken with cellulase, leaching of effective components in cells is accelerated, and the utilization rate of raw materials is greatly increased; the atropa belladonna extract prepared with the method can be taken as a novel vascular smooth muscle relaxing medicine and used for preparing medicines for treating hypertension, and a new scheme can be provided for clinical treatment of hypertension.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method and application of belladonna extract. Background technique [0002] Belladonna is a herbaceous plant in the nightshade family. The perennial herb native to Western Europe was later transplanted to North Africa, West Asia, North America and other places, and it was also introduced and cultivated in China. Its native place is the shady and humid area of ​​the mountain, and it grows in groups in the calcareous soil. [0003] The active ingredients in belladonna are scopolamine alkaloids, which are mainly used for abdominal pain caused by stomach cramps, duodenal ulcers, ureteral stones, gastritis and vomiting and diarrhea caused by stomach cramps. [0004] According to "Chinese Pharmacopoeia" (page 397 of the 2010 edition), the preparation method of belladonna extract is: get 1000 grams of belladonna coarse powder, use 85% ethanol as a solvent, and soak it a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P9/08A61P9/12
Inventor 于孟飞陈梦林马琳刘庆华
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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