Process for recycling methyl tertbutyl ether-tetrahydrofuran from waste solvent obtained in statins medicine synthetic process by using high-gravity beds

A technology of methyl tertiary butyl ether and tetrahydrofuran, applied in the field of chemical waste solvent recovery, can solve problems such as floor space, energy consumption disadvantage, and cost impact.

Inactive Publication Date: 2018-01-16
南京揽博环境技术有限公司 +1
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Although this process method can obtain regenerated solvents that meet the requirements of mechanical application, it has disadvantages in terms of floor space and energy consumption compared with supergravity beds. Especially, energy consumption is the main economic index in the separation process, and its level directly affects to the cost of separation, and are therefore extremely important evaluation criteria

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  • Process for recycling methyl tertbutyl ether-tetrahydrofuran from waste solvent obtained in statins medicine synthetic process by using high-gravity beds

Examples

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example 1

[0016] There is a batch of 50,000 kg of waste solvent, which contains 11.08% of isoprene, 49.56% of methyl tert-butyl ether, 18.12% of tetrahydrofuran, 20.88% of tert-butyl acetate and 0.36% of other impurities as determined by gas chromatography. The water content is 2.17% as measured by a moisture meter. At a rate of 700kg / h, the waste solvent is pumped from the transition feed tank into the first supergravity bed. The turntable speed of the supergravity bed is 1000r / min, the reflux ratio is controlled between 2 and 4, and the temperature at the top of the tower is controlled at 34°C to 35°C. Operating under normal pressure conditions, a mixture of isoprene and water can be obtained at the top of the tower, and the upper layer can obtain isoprene with a purity of 98.26% after decanting. In the composition of the first supergravity bed column liquid, isoprene is 2.85%, methyl tert-butyl ether is 53.97%, tetrahydrofuran is 19.88%, tert-butyl acetate is 22.91%, other impuritie...

example 2

[0018] There is a batch of 42,000 kg of waste solvent, which contains 13.56% isoprene, 42.76% methyl tert-butyl ether, 23.43% tetrahydrofuran, 19.83% tert-butyl acetate and 0.42% other impurities as determined by gas chromatography. The water content is 1.96% as measured by a moisture meter. At a rate of 640kg / h, the waste solvent is pumped from the transition feed tank into the first supergravity bed. The turntable speed of the supergravity bed is 1000r / min, the reflux ratio is controlled between 4 and 6, and the temperature at the top of the tower is controlled at 35°C to 36°C. Operating under normal pressure conditions, a mixture of isoprene and water can be obtained at the top of the tower, and isoprene with a purity of 98.11% can be obtained in the upper layer through decanting. In the composition of the first supergravity bed column liquid, isoprene is 3.02%, methyl tert-butyl ether is 47.52%, tetrahydrofuran is 26.48%, tert-butyl acetate is 22.53%, other impurities are...

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Abstract

The invention relates to a methyl tertbutyl ether-tetrahydrofuran rectification process, which takes rectification as a core method and aims at recycling an organic waste solvent in a statins medicinesynthetic process, wherein the methyl tertbutyl ether-tetrahydrofuran meets application requirement. According to the process, a waste solvent enters the space between the rotors in the second and third layers of a first high-gravity bed, the temperature of a tower top is controlled at 34-36 DEG C, the tower top product is layered with a decanter, and an isoprene coarse product is obtained from the top layer. A tower bottom material enters the space between the rotors in the first and second layers of a second high-gravity bed, the operation temperature of the tower top is controlled at 55-58DEG C, and a methyl tertbutyl ether-tetrahydrofuran mixed solvent with the purity more than 97% and the water content less than 1000 ppm is obtained from the tower top. According to the process, a recycling process using two in-series high-gravity beds is adopted. The process is simple in route, small in equipment space occupation, and low in energy consumption. The recycling utilization rate ofa regenerative solvent is improved, and the economic benefit of an enterprise is increased.

Description

technical field [0001] The invention relates to the field of recovery of chemical waste solvents, in particular to a separation device with two hypergravity beds connected in series as the core to recover waste solvents in the synthesis process of statins to obtain methyl tert-butyl ether with high purity - Tetrahydrofuran mixed solvent, to meet the requirements of recycling. Background technique [0002] Statins are hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. In addition to significantly reducing cholesterol and low-density lipoprotein cholesterol in the body, they can also slightly increase high-density lipoprotein cholesterol and reduce triglycerides. It is a commonly used drug for the treatment of cardiovascular diseases. In the preparation process, a large amount of isoprene, methyl tert-butyl ether, tetrahydrofuran and tert-butyl acetate are used as solvents, thus generating a large amount of waste organic solvents. At normal temperature and pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C41/42C07C43/04C07D307/08C07C7/04C07C11/18C07C67/54C07C69/14B01D3/30
CPCY02P20/50
Inventor 张弛吕佳逊秦磊甘雨赖水红王炜
Owner 南京揽博环境技术有限公司
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