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Lindera aggregata compound with antagonistic effect for inflammatory bowel diseases and application thereof

A technology of inflammatory bowel disease and composition, which is applied in the field of traditional Chinese medicine, can solve problems such as easy recurrence, surgical treatment, and failure to meet clinical needs, and achieve the effects of regulating gastrointestinal motility, restoring gastrointestinal motility, and reducing colonic congestion and edema

Active Publication Date: 2018-01-19
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above drugs can improve IBD to varying degrees, but they are prone to relapse after treatment, and surgery is often required, which is far from meeting the clinical needs

Method used

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  • Lindera aggregata compound with antagonistic effect for inflammatory bowel diseases and application thereof
  • Lindera aggregata compound with antagonistic effect for inflammatory bowel diseases and application thereof
  • Lindera aggregata compound with antagonistic effect for inflammatory bowel diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The present invention provides a black medicine composition capable of preventing and treating inflammatory bowel disease. The black medicine composition is formed by mixing the black medicine extract and Dendrobium officinale polysaccharide, and the weight percentage of the black medicine extract in the black medicine composition is 1% to 1%. 99%;

[0024]The preparation method of the black medicine extract is as follows: the black medicine decoction pieces are added to ethanol with 8 times the volume of the decoction pieces, the volume concentration of ethanol is 50%, and the reflux extraction is carried out at 90° C. for 2 times, each time for 1 hour; the filtrate is filtered, After standing to cool, centrifuge at 1500rpm for 5min, take the supernatant, recover ethanol under reduced pressure, and then dry to obtain the black medicine extract;

[0025] The preparation method of the polysaccharide of Dendrobium candidum is as follows: add Dendrobium candidum to 8 times...

Embodiment 2

[0027] The present invention provides a black medicine composition capable of preventing and treating inflammatory bowel disease. The black medicine composition is formed by mixing the black medicine extract and Dendrobium officinale polysaccharide, and the weight percentage of the black medicine extract in the black medicine composition is 1% to 1%. 99%;

[0028] The preparation method of the black medicine extract is as follows: add the black medicine decoction pieces to ethanol with 12 times the volume of the decoction pieces, the volume concentration of ethanol is 90%, and reflux extraction at 100°C for 3 times, each time for 1.5h; filter the filtrate , after standing to cool, centrifuge at 3500rpm for 10min, take the supernatant, recover ethanol under reduced pressure, and then dry to obtain the black medicine extract;

[0029] The preparation method of the polysaccharide of Dendrobium candidum is as follows: add Dendrobium candidum to 12 times the volume of ethanol, the ...

Embodiment 3

[0035] Example 3: Research on the influence of different concentrations of alcohol solutions on the extraction rate of components such as araegina lactone in the extract

[0036] 1. Experimental materials

[0037] 1.1. Chromatographic conditions: Chromatographic instrument: Agilent 1200HPLC instrument, chromatographic column: Ultimate-XB-C 18 (5μm 4.6*250nm), detection wavelength: 235nm, column temperature: 30°C, flow rate: 1ml / min, mobile phase: ultrapure water (A)-acetonitrile (C), gradient elution: 0min, 56%C, 44 %A; 50min, 56%C, 44%A; 55min, 95%C, 5%A; 60min, 95%C, 5%A.

[0038] 1.2. Reference substances: isoagalactone (Lot: 160710), buyalinolactone (Lot: 160421), and buyarolactone (Lot: 160510) were purchased from Beijing Beina Chuanglian Biotechnology Research Institute;

[0039] 1.3. Preparation of different extracts of black yao yao: take appropriate amount of black yao yao decoction pieces, add 10 times the amount of water respectively, volume concentration is 30%, ...

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Abstract

The invention discloses a lindera aggregata compound with an antagonistic effect for inflammatory bowel diseases and an application thereof. The lindera aggregata compound is prepared by mixing lindera aggregata extract with dendrobium officinale polysaccharides, wherein the weight of the lindera aggregata extract is 1%-99% of the weight of the lindera aggregata compound. A preparation method forthe lindera aggregata extract comprises the following steps: adding a lindera aggregata tablet into ethyl alcohol in volume concentration of 50-90%, heating, performing reflux extraction and concentrating, thereby acquiring the lindera aggregata extract. The preparation method for the dendrobium officinale polysaccharides comprises the following steps: adding dendrobium officinale into ethyl alcohol, performing water extraction and performing alcohol precipitation. The compound has the effects of relieving the weight loss of enteritis model rat, obviously relieving colon congestion edema, intestinal wall expansion and mucosal ulcer injury, reducing intestinal index and intestinal weight per unit length, regulating intestinal immunologic derangement, restraining intestinal inflammation medium expression, relieving intestinal inflammation response, relieving histopathological change of colon, maintaining intestinal tract state, and the like, and can be used for preparing a drug for preventing and controlling inflammatory bowel diseases.

Description

technical field [0001] The present invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine combination which is composed of herbal extracts and dendrobium polysaccharides and has the ability to significantly antagonize inflammatory bowel disease and its preparation for preventing, improving and treating inflammatory bowel disease. Pharmaceutical applications. Background technique [0002] Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (Ulcerative colitis, UC), is a chronic nonspecific intestinal Inflammatory disease, which can lead to severe deterioration of the patient's biochemical quality, often requiring life-long medication or even surgery. Epidemiological studies have shown that the incidence of IBD is gradually increasing around the world. Its pathogenesis is still unclear, and it is prone to recurrent attacks and difficult to cure. It is also in a state of chr...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K36/8984A61P29/00A61P1/00A61P1/04A61K31/715
Inventor 楼招欢黄敏聪吴月国
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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