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Determination method for detecting 14 disabled colorants in cigarette paper by ultra-performance liquid chromatography-tandem mass spectrometry

A technology of ultra-high performance liquid chromatography and tandem mass spectrometry, which is applied in the field of determination of 14 banned colorants in cigarette paper by ultra-high performance liquid chromatography-tandem mass spectrometry, which can solve difficult separation, large matrix interference, and many kinds of colorants problems, to achieve the effect of reducing interference, less environmental pollution, and simple pre-treatment methods

Inactive Publication Date: 2018-01-19
CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods have a lot of matrix interference, and there are many kinds of colorants, so it is difficult to completely separate them. Liquid chromatography-tandem mass spectrometry can overcome such problems by using the multi-reaction ion monitoring mode.

Method used

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  • Determination method for detecting 14 disabled colorants in cigarette paper by ultra-performance liquid chromatography-tandem mass spectrometry
  • Determination method for detecting 14 disabled colorants in cigarette paper by ultra-performance liquid chromatography-tandem mass spectrometry

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0033] 1. Instruments and reagents:

[0034] Colorants are prohibited, acetonitrile and ethanol are chromatographic grade reagents; they meet the requirements of first-grade water in GB / T 6682.

[0035] Waters TQS quadrupole tandem mass spectrometer; Swiss Mettler AE 163 electronic balance (sensitivity: 0.0001g).

[0036] 2. Sample handling:

[0037] Weigh 0.5 g carton packing paper sample (accurate to 0.01 g), and place it in a 50 mL Erlenmeyer flask with a stopper. Accurately add 20mL extract: ethanol, ultrasonically extract for 30 min; sample purification: stand still for 5 min, pipette 1.5 mL of extract into a 2 mL centrifuge tube, and centrifuge at 8000 rpm for 5 min. Aspirate 1mL of the supernatant, blow it nearly dry with nitrogen, reconstitute with 1mL of acetonitrile, and filter through a 0.22μm organic phase filter. Pipette 200 μL of the filtrate, dilute the sample to 1.0 mL with acetonitrile, and use it as the sample solution for UPLC-MS / MS analysis;

[0038] ...

example 2

[0042] As the method described in Example 1, another tipping paper sample for cigarettes was selected, and no forbidden colorant was detected in the sample.

example 3

[0044] According to the method described in Example 1, another cigarette paper sample was selected, and the forbidden colorant was not detected in the sample.

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Abstract

The invention belongs to the technical field of physical and chemical inspection of harmful substance residues in cigarette paper and particularly relates to a determination method for detecting 14 disabled colorants in cigarette paper by ultra-performance liquid chromatography-tandem mass spectrometry. The determination method is characterized by comprising the following steps: firstly, cutting up the cigarette paper and then adding ethanol; secondly, carrying out ultrasonic extraction, centrifuging an extracting solution, then filtering, diluting with acetonitrile, and directly determining the disabled colorants in the paper by the ultra-performance liquid chromatography-tandem mass spectrometry. By means of the method, residual quantity of the disabled colorants in the paper can be detected quickly and accurately; and the method has the advantages of environmental protection, accurate results, less interference, high sensitivity and high repeatability.

Description

technical field [0001] The invention belongs to the technical field of physical and chemical inspection of harmful substance residues in cigarette paper, and mainly relates to a method for measuring 14 prohibited colorants in cigarette paper, tipping paper, carton wrapping paper, and cigarette paper, specifically by using ultrasonic The forbidden colorant is extracted by way of ultra high performance liquid chromatography-tandem mass spectrometry. Background technique [0002] Synthetic colorants are mainly made of aromatic chemical products such as benzene, toluene, naphthalene, etc., and are compounded through a series of organic reactions such as sulfonation, nitration, halogenation, and azolation. They have no nutritional value themselves, but due to their low cost , Bright color, strong tinting power, stable properties and convenient color matching, can increase the sensory beauty of food and improve people's appetite, and are widely used in food production and processi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 杨飞李中皓范子彦邓惠敏边照阳王颖刘珊珊唐纲岭
Owner CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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