Biomimetic cartilage material having biological activity and preparation method thereof

Abstract

The invention provides a novel biomimetic cartilage material having biological activity and a preparation method thereof. The biomimetic cartilage material is a composite material which is prepared with a biomaterial with bone induced activity and polyvinyl alcohol as raw materials and through combination of an ultrasound method and a sol-gel method. From the perspectives of material biomimetics and functional biomimetics, the improved sol-gel method (namely ultrasonic-sol-gel method) is adopted for compositing of polyvinyl alcohol and an inorganic material, a biomimetic artificial cartilage having biological induced activity is prepared, mainly manifests in relatively good integration of the material and bones and has no obvious rejection, the inorganic material has good dispersion, no agglomeration phenomenon exists, the particle size distribution is controllable, and a crystal form structure is relatively ideal.

Description

technical field [0001] The invention relates to the fields of medical equipment and biomaterials, in particular to a bionic cartilage material with bioactivity and a preparation method thereof. Background technique [0002] Joints are functional connections between bones in the skeletal system. In the synovial joint, the bone end of the joint is covered with a layer of 1-7mm thick white transparent connective tissue—articular cartilage, which is the load-bearing tissue that makes up the articular surface of the synovial joint, which can reduce the friction of the articular surface during repeated joint movements. It has the characteristics of lubrication and wear resistance, and also has the function of reducing impact and absorbing shock. [0003] Degeneration or damage of articular cartilage caused by trauma or disease is relatively common in clinical practice. However, due to the special articular cartilage tissue, there are no blood vessels, lymphatic vessels and nerves...

AI Technical Summary

Problems solved by technology

However, the mechanical strength of PVA hydrogel is insufficient, the surface is smooth, and there is no biological activity. The bonding performance between the cartilage prosthesis and the bone base is very poor, which directly affects the fixation and repair function of the cartilage prosthesis. Generally, biomaterials with osteoinductive activity such as Hydroxyapatite, bioactive glass, etc. are compounded with polyvinyl alcohol hydrogel, so the compounding of polyvinyl alcohol and inorganic materials has become the focus and hotspot of research

[0007] Most of the composite technologies reported in the literature or disclosed in the patents use simple mechanical stirring or in-situ precipitation composite technology. The main disadvantages of this process are: 1) the stirring is not uniform, and clusters often occur; 2) the process is unstable, It is difficult to control and cannot be produced industrially; 3) The local aggregation of inorganic materials leads to an excessive local friction coefficient of the composite material. If this part is located between the joints, it will inevitably affect the lubrication of the material and affect the normal activities of the joints

[0009] It is an ideal solution to use the sol-gel method for the compounding of polyvinyl alcohol and inorganic materials, but when the concentration of polyvinyl alcohol solution is high, the corresponding viscosity will also increase, making the material compounding more difficult. If polyethylene If the concentration of alcohol solution is small, the cost of industrial production will increase

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