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Sport fatigue resisting folic acid layered double hydroxid (LDH) nano nutritional supplement and preparation method thereof

A double hydroxide and hydroxide technology, applied in the directions of antitoxins, drug combinations, pharmaceutical formulations, etc., can solve the problems of low drug stability, short drug half-life, lack of specificity, etc., and achieve good biocompatibility, Good anti-exercise fatigue, good ability effect

Inactive Publication Date: 2018-02-13
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composite drug-loading material of functionalized drug molecules and layered double hydroxide can not only improve the safety, effectiveness, reliability and patient compliance of drugs, but also solve the problems that other preparations may encounter, such as Low drug stability or solubility, low absorption or biological instability (enzymes, pH, etc.), short drug half-life and lack of specificity, low therapeutic index and cellular barrier issues

Method used

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  • Sport fatigue resisting folic acid layered double hydroxid (LDH) nano nutritional supplement and preparation method thereof
  • Sport fatigue resisting folic acid layered double hydroxid (LDH) nano nutritional supplement and preparation method thereof
  • Sport fatigue resisting folic acid layered double hydroxid (LDH) nano nutritional supplement and preparation method thereof

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Embodiment 1

[0049] Preparation of Folic Acid / Layered Double Hydroxide Nanometer Drug Delivery System

[0050] (1) Preparation of folic acid-LDH by co-precipitation method

[0051] 1. Prepare Mg(NO 3 ) 2 ·6H 2 O(0.6923g, 0.027mol) and Al(NO 3 ) 3 ·9H 2 A total of 90ml of O (0.5401g, 0.014mol) metal mixed salt solution, in which the molar ratio of Mg / Al is 2:1; and 30ml of folic acid solution (0.2118g, 0.016mol);

[0052] 2. Put the metal salt mixed solution in N 2 Under the atmosphere, it was added dropwise to the vigorously stirred folic acid aqueous solution, during which the co-precipitation reaction temperature of the system was maintained at 80°C, and 1M NaOH solution was continuously added and the pH of the system was kept within the range of 10.0±0.2;

[0053] 3. Put the resulting suspension in N 2 React under atmosphere for 5 hours;

[0054] 4. Filtration and washing: Use a suction filter to filter the suspension, wash 2-3 times and collect the precipitate;

[0055] 5. Vacuum drying the filte...

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Abstract

The invention relates to a sport fatigue resisting folic acid layered double hydroxide (LDH) nano nutritional supplement and a preparation method thereof. The sport fatigue resisting folic acid LDH nano nutritional supplement is prepared by a co-precipitation method, and the functions thereof in resisting oxidation in vitro and resisting sports fatigue in vivo are studied. Folic acid has a relatively strong anti-oxidation function and plays an important role in maintaining the body function level, promoting fatigue recovery and enhancing body immunity. In the invention, the sport fatigue resisting folic acid layered double LDH nano nutritional supplement is synthesized by use of the advantages of a layered inorganic nano material (LDH) serving as a drug carrier; the invention has an important application value in developing a functional sport nutritional supplement.

Description

Technical field [0001] The invention belongs to the technical field of nano material preparation, and in particular relates to an anti-sport fatigue folic acid layered double hydroxide nano nutritional supplement and a preparation method thereof. Background technique [0002] Exercise fatigue refers to the inability of the body's physiological processes to maintain its function at a certain level and the inability to maintain a predetermined exercise intensity. The increase in oxygen consumption of the body during or after exercise, or the activation of specific pathways, is the main source of reactive oxygen radicals (ROS). Studies have shown that with the increase of exercise intensity and time, the production of free radicals increases sharply. When the body's own ability to scavenge free radicals is exceeded, the anti-oxidant level of tissues decreases, and the body produces a state of oxidative stress. Exercise oxidative stress caused by free radicals is one of the main cau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/69A61K47/02A61K31/519A61P39/00A61P39/06
CPCA61K9/143A61K31/519
Inventor 秦黎黎惠娟陈佳磊游松辉卢天凤王玥
Owner TONGJI UNIV
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