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Copper oxide-doped potassium-sodium niobate antibacterial piezoelectric ceramic implant as well as preparation and application of implant

A technology of potassium sodium niobate and piezoelectric ceramics, which is applied in the fields of application, botany equipment and methods, prostheses, etc., can solve the problems of no double-effect antibacterial materials, unfavorable processing and molding, and limited clinical use, etc. Lead-containing non-polluting biocompatibility, high mechanical properties, and the effect of improving piezoelectricity

Inactive Publication Date: 2018-02-23
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Copper is usually added to the surface coating of medical materials to achieve antibacterial effect, but because the coating material is easy to fall off on ceramic-based materials, it is not conducive to processing and molding, which limits its clinical use
So far, no reports have been found about the dual-effect antibacterial materials that use copper and the piezoelectricity of the material itself and its use in antibacterial applications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A preparation method of copper oxide doped potassium sodium niobate antibacterial piezoelectric ceramic implant, comprising the following steps:

[0043] (1) Put absolute ethanol, niobium pentoxide, sodium carbonate and potassium carbonate in a ball milling device for 6 hours at a speed of 300 rpm, let stand for 30 minutes, dry at 70°C to constant weight, calcinate at 750°C for 2 hours, and grind into powder body to obtain potassium sodium niobate precursor powder; the mass ratio of niobium pentoxide, potassium carbonate and sodium carbonate is 5:1.0:0.8; the ratio of the amount of absolute ethanol to the total mass of niobium pentoxide, potassium carbonate and sodium carbonate 5mL: 1g;

[0044] (2) Place absolute ethanol, copper oxide and potassium sodium niobate precursor powder in a ball milling device for ball milling at 300rpm for 6h, let stand for 30min, dry at 70°C to constant weight, and calcinate at 750°C for 2h to obtain copper oxide Doped with potassium sodi...

Embodiment 2

[0049] A preparation method of copper oxide doped potassium sodium niobate antibacterial piezoelectric ceramic implant, comprising the following steps:

[0050] (1) Put anhydrous ethanol, niobium pentoxide, sodium carbonate and potassium carbonate in a ball milling device for 8 hours at 300 rpm, let stand for 30 minutes, dry at 75°C to constant weight, calcinate at 750°C for 2 hours, and grind into powder body to obtain potassium sodium niobate precursor powder; the mass ratio of niobium pentoxide, potassium carbonate and sodium carbonate is 5:1.2:1; the ratio of the amount of absolute ethanol to the total mass of niobium pentoxide, potassium carbonate and sodium carbonate 5mL: 1g;

[0051] (2) Place absolute ethanol, copper oxide and potassium sodium niobate precursor powder in a ball milling device for 8 hours at a speed of 300 rpm, let it stand for 30 minutes, dry at 75°C to constant weight, and calcinate at 750°C for 2 hours to obtain copper oxide Doped potassium sodium n...

Embodiment 3

[0056] A preparation method of copper oxide doped potassium sodium niobate antibacterial piezoelectric ceramic implant, comprising the following steps:

[0057] (1) Place anhydrous ethanol, niobium pentoxide, sodium carbonate and potassium carbonate in a ball milling device and mill at 300rpm for 10h, let stand for 30min, dry at 70°C to constant weight, calcinate at 750°C for 2h, and grind into powder body to obtain potassium sodium niobate precursor powder; the mass ratio of niobium pentoxide, potassium carbonate and sodium carbonate is 5:1.3:1; the ratio of the amount of absolute ethanol to the total mass of niobium pentoxide, potassium carbonate and sodium carbonate 10mL:1g;

[0058] (2) Place absolute ethanol, copper oxide and potassium sodium niobate precursor powder in a ball milling device for 10 h at a speed of 300 rpm, let it stand for 30 min, dry at 70°C to constant weight, and calcinate at 750°C for 2 h to obtain copper oxide Doped with potassium sodium niobate cer...

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Abstract

The invention belongs to the technical field of antibacterial implant materials, and discloses a copper oxide-doped potassium-sodium niobate antibacterial piezoelectric ceramic implant as well as preparation and application of the implant. The method comprises the following steps: (1) adding a solvent, niobium pentoxide, sodium carbonate and potassium carbonate into a ball milling device for ballmilling, standing, drying, calcining, and grinding into powder, to obtain potassium-sodium niobate precursor powder; (2) adding a solvent, copper oxide and the potassium-sodium niobate precursor powder into the ball milling device for ball milling, standing, drying, and calcining, to obtain copper oxide-doped potassium-sodium niobate ceramic powder; (3) evenly mixing the copper oxide-doped potassium-sodium niobate ceramic powder with a binder, granulating, forming, discharging glue, performing dense sintering, to obtain a ceramic sheet; and (4) polarizing the ceramic sheet, to obtain the copper oxide-doped potassium-sodium niobate antibacterial piezoelectric ceramic implant. The method is simple, and the prepared implant has a good antibacterial effect and stability.

Description

technical field [0001] The invention belongs to the technical field of preparation of antibacterial implant materials, in particular to a piezoelectric ceramic implant that utilizes the piezoelectric properties of the implant material itself and the metal copper ions released by it to achieve double-effect antibacterial purposes, and its preparation and application. application. Background technique [0002] Medical implants are widely used in bone repair, orthopedic surgery, and artificial dental implants, but implant infection is still a difficult clinical problem. During the implantation process, Staphylococcus aureus and Escherichia coli may cause orthopedic implant infection. Once implant infection occurs, it may cause local tissue destruction, inflammation, and implant failure. Repeated attacks of infection are difficult to control, resulting in recurrence. Surgery increases the mental and economic burden of patients, and increases the risk of reoperation. Therefore,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/495A61L27/50A61L27/10A01N59/20A01P1/00A01P3/00
CPCA01N59/20A61L27/10A61L27/50C04B35/495C04B2235/3281C04B2235/442C04B2235/96
Inventor 宁成云翟锦霞陈芳于鹏辛敏轩陈俊祺何佳鹏
Owner SOUTH CHINA UNIV OF TECH
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