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Traditional Chinese medicine composition for preventing and treating mammary gland hyperplasia and preparation method thereof

A technology of mammary gland hyperplasia and composition, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., which can solve problems such as difficult to deal with complex and changeable, low pertinence of patented medicines, and complex and changeable mammary gland hyperplasia syndromes

Active Publication Date: 2018-02-27
HEBEI UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the syndrome types of hyperplasia of mammary glands are complex and changeable, and can be roughly classified into three types: stagnation of phlegm and blood stasis, liver depression and qi reversal, and kidney deficiency and blood deficiency; most patients with phlegm-dampness type are obese, lethargic, lethargic, oily skin, obvious body odor, and profuse leukorrhea Thick, poor stool, sticky phlegm, red tongue with yellow greasy coating, dull breast pain during menstruation; Liver stagnation and qi stagnation type symptoms include unbearable breast distension and pain before menstruation, worse when angry, usually prone to depression and anger, dark tongue , insomnia and dreaminess; patients with blood deficiency have pale or chlorotic complexion, fatigue, pale lips and nails, less menstrual flow and pale color, dull pain in breast hyperplasia during menstruation, thin and weak pulse; Tinnitus, frequent urination at night, loss of libido, insomnia and forgetfulness, leucorrhea, dull breast pain during menstruation, pale tongue, thready and weak pulse; the existing proprietary medicines are less targeted and difficult to deal with complex and changeable syndromes

Method used

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  • Traditional Chinese medicine composition for preventing and treating mammary gland hyperplasia and preparation method thereof
  • Traditional Chinese medicine composition for preventing and treating mammary gland hyperplasia and preparation method thereof
  • Traditional Chinese medicine composition for preventing and treating mammary gland hyperplasia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0055] [Experimental Example 1] Therapeutic effect of the medicine of the present invention on hormone-induced mammary enlargement in rats

[0056] 1 material

[0057] 1.1 Animals

[0058] SD healthy non-pregnant rats, female, weighing 180-220 g, were provided by the Experimental Animal Center of Hebei Medical University, and were adaptively fed for one week before the experiment.

[0059] Reagents and Drugs

[0060] Estradiol benzoate (1mL: 2mg × 10 sticks) and progesterone (1mL: 10mg × 10 sticks) injections were purchased from Tianjin Jinyao Pharmaceutical Co., Ltd. (batch numbers 150215 and 150312 respectively), E 2 , P, and PRL radioimmunoassay kits were purchased from Beijing Furui Bioengineering Company (batch number 150603), and tamoxifen was produced by Yangzijiang Pharmaceutical Group Co., Ltd. (batch number 15041501).

[0061] Rujieqing (RJQ) prescription Chinese medicine decoction pieces were purchased from Lerentang Pharmaceutical Group Co., Ltd., and were ident...

experiment example 2

[0097] [Experimental example 2] the clinical observation of drug treatment mammary gland hyperplasia of the present invention

[0098] 1 Case information:

[0099] 130 outpatients were selected; all were female patients; 31 patients aged 20-30 years, 60 patients aged 30-40, 29 patients aged 40-50, 10 patients aged 50-60, 130 patients were randomly divided into treatment group, Control group; 65 people in the treatment group (average age 34 years old, disease course 3 months to 6 years, 32 people with unilateral breast disease, 33 people with bilateral breast disease); 65 people in the control group (average age 33 years old, disease course 5 months ——8 years, 30 patients with unilateral breast disease and 35 patients with bilateral breast disease); the data of the two groups are comparable in terms of age, disease duration, and disease distribution.

[0100] Diagnostic criteria

[0101] Refer to the diagnostic criteria of mammary gland hyperplasia in "Surgery": unilateral or...

Embodiment 1

[0118] [embodiment 1] medicine capsule of the present invention

[0119] a) Weigh the raw drug for later use, the dosage of the raw drug is as follows:

[0120] 32 parts of white peony

20 parts of red peony

Atractylodes 20 parts

Motherwort 16 parts

Zeeland 16 servings

Prunella vulgaris 16 parts

bergamot 12 servings

Citrus aurantium 12 parts

Cyperus 12 parts

August letter 12 copies

Passepartout 9 copies

9 copies of three needles

6 parts birch bark

6 servings of oatmeal

Indigo Daisy 3 parts

[0121] b) decocting the 6 traditional Chinese medicines of Radix Paeoniae Rubra, Atractylodes Rhizoma Atractylodes Rhizome, Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhi...

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating mammary gland hyperplasia. The traditional Chinese medicine composition is mainly prepared from the medicines such as radix paeoniae alba, radix paeoniae rubra, herba leonuri, herba lycopi, common selfheal spike, fructus citri sarcodactylis, fructus aurantii immaturus, rhizoma cyperi, fiverleaf akebia fruit and fructus liquidambaris according to certain weight proportion. The traditional Chinese medicine composition can be made into any common dosage form for oral administration. The whole formula has the functions of nourishing blood and soothing liver, activating blood and promoting qi circulation, inducing diuresis and removing stasis and removing stasis and relieving pain, and realizes an exact curative effect on preventing and treating the mammary gland hyperplasia.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine for preventing and treating breast diseases. Background technique [0002] Mammary gland hyperplasia is a common female breast disease; in recent years, with changes in diet structure, accelerated pace of life, and increased work pressure, the incidence of mammary gland hyperplasia has shown an obvious upward trend, and is developing at a younger age; the disease is harmful to women's health increasingly attracted people's attention. [0003] The main mechanism of the disease is hyperplasia of mammary epithelium and fibrous tissue caused by endocrine disorders; structural degeneration of breast tissue ducts and milk lobules and progressive connective tissue growth; manifested as milk leaf thickening, nodular granules, breast tenderness and nipple pain Symptoms such as galactorrhea; and are closely related to factors such as dietary fatigue, emotional changes, menstrual cycle, etc.; the...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61P15/14
CPCA61K36/185A61K36/195A61K36/28A61K36/284A61K36/29A61K36/315A61K36/53A61K36/533A61K36/536A61K36/65A61K36/704A61K36/71A61K36/752A61K36/8905A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 杨旭杰裴晓华
Owner HEBEI UNIV OF CHINESE MEDICINE
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