2,3-epoxy-2-propylsulfone-5,8-dimethoxy-1,4-naphthoquinone, its preparation method and medicine containing it
A dimethoxy, naphthoquinone technology, applied in the field of medicine, can solve the problems of lack of discrimination ability of chemotherapy, decreased blood picture, liver function damage, etc.
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[0054] Example: Preparation of 2,3-epoxy-2-propylsulfone-5,8-dimethoxy-1,4-naphthoquinone compound in this example:
[0055] 1. Synthesis of 2-propylmercapto-5,8-dimethoxy-1,4-naphthoquinone
[0056] In a 100ml reaction bottle, add 218.21mg (1mmol) of 5,8-dimethoxy-1,4-naphthoquinone and 50ml of methanol, mix well, add 111.02μl (1.5mmol) of 1-propanethiol, and react at room temperature for 4 hours Finally, 149.8 mg (0.2 mmol) of sodium dichromate and 27.2 μl (0.75 mmol) of concentrated sulfuric acid were added to the mixture, and the reaction was completed after 5-10 minutes. Extracted with dichloromethane and saturated brine, dried with an appropriate amount of anhydrous sodium sulfate, filtered, and concentrated to dryness to obtain a crude product, which was prepared by column chromatography, 2-propylmercapto-5,8-dimethoxy-1,4- naphthoquinone.
[0057] 2. Synthesis of 2,3-epoxy-2-propylsulfone-5,8-dimethoxy-1,4-naphthoquinone (EPDMNQ)
[0058] In a 50ml reaction bottle, ...
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