Preparation and application of zeolite imidazolate framework material ionic liquid organic polymer stationary phase monolithic column for capillary electrochromatography

A technology of capillary electrochromatography and zeolite imidazolate, which is applied in the field of analytical chemistry, can solve problems such as lack of sources of stationary phase materials for an organic polymer capillary electrochromatography monolithic column, and achieve rapid and efficient separation and detection, excellent chromatographic performance and simple preparation method. Effect

Active Publication Date: 2019-06-25
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings and deficiencies in the prior art, solve the problem of lack of sources of stationary phase materials for the current organic polymer capillary electrochromatography monolithic column, and provide a zeolite imidazolate framework material ionic liquid organic polymer stationary phase capillary electrochromatography Preparation method of monolithic column, and application of prepared organic polymer capillary electrochromatographic column

Method used

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  • Preparation and application of zeolite imidazolate framework material ionic liquid organic polymer stationary phase monolithic column for capillary electrochromatography
  • Preparation and application of zeolite imidazolate framework material ionic liquid organic polymer stationary phase monolithic column for capillary electrochromatography
  • Preparation and application of zeolite imidazolate framework material ionic liquid organic polymer stationary phase monolithic column for capillary electrochromatography

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Cut off a 40cm long quartz capillary (inner diameter 100μm). After pretreatment, prepare a 50% (v / v) methanol solution of methacryloxypropyltrimethoxysilane, suck it into a syringe and inject it into the pretreated capillary, Connect the two ends with Teflon to form a ring, and place it in a 45°C water bath overnight to react to vinylize the inner wall of the capillary; then rinse the capillary with methanol for 30 minutes, and dry it with N 2 Blow dry and set aside.

[0025] (2) Mix 91.8 mg of ionic liquid 1-allyl-3-methylimidazole bromide, 87 μL of ethylene glycol dimethacrylate, 388 μL of N,N-dimethylformamide, 123 μL of n-propyl Alcohol, 309 μL of dodecanol, 2.8 mg of azobisisobutyronitrile, and 0-10 mg of ZIF-8 were placed in a 2 mL eppendorf tube, and ultrasonically mixed for 10 min to remove air bubbles.

[0026] (3) Inject the homogeneous solution obtained in step (3) into the capillary treated in step (2), control the injection length to 35.5 cm, seal both...

Embodiment 2

[0031] (1) Cut off a 40cm long quartz capillary (inner diameter 100μm). After pretreatment, prepare a 50% (v / v) methanol solution of methacryloxypropyltrimethoxysilane, suck it into a syringe and inject it into the pretreated capillary, Connect the two ends with Teflon to form a ring, and place it in a 45°C water bath overnight to react to vinylize the inner wall of the capillary; then rinse the capillary with methanol for 30 minutes, and dry it with N 2 Blow dry and set aside.

[0032] (2) Mix 91.8 mg of ionic liquid 1-allyl-3-methylimidazole bromide, 87 μL of ethylene glycol dimethacrylate, 388 μL of N,N-dimethylformamide, 123 μL of n-propyl Alcohol, 309 μL of dodecanol, 2.8 mg of azobisisobutyronitrile, and 15 mg of ZIF-8 were placed in a 2 mL eppendorf tube, and were mixed uniformly by ultrasonication for 10 min to remove air bubbles.

[0033] (3) Inject the homogeneous solution obtained in step (3) into the capillary treated in step (2), control the injection length to 35....

Embodiment 3

[0035] (1) Cut off a 40cm long quartz capillary (inner diameter 100μm). After pretreatment, prepare a 50% (v / v) methanol solution of methacryloxypropyltrimethoxysilane, suck it into a syringe and inject it into the pretreated capillary, Connect the two ends with Teflon to form a ring, and place it in a 45°C water bath overnight to react to vinylize the inner wall of the capillary; then rinse the capillary with methanol for 30 minutes, and dry it with N 2 Blow dry and set aside.

[0036] (2) Mix 91.8 mg of ionic liquid 1-allyl-3-methylimidazolium hexafluorophosphate, 87 μL of ethylene glycol dimethacrylate, 388 μL of N,N-dimethylformamide, 123 μL of n-propanol, 309 μL of dodecanol, 2.8 mg of azobisisobutyronitrile, and 10 mg of ZIF-90 were placed in a 2 mL eppendorf tube, and the mixture was homogeneously mixed by ultrasonication for 10 min to remove air bubbles.

[0037] (3) Inject the homogeneous solution obtained in step (3) into the capillary treated in step (2), control t...

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Abstract

The invention discloses preparation and application of a zeolite imidazate framework material ionic liquid organic polymer fixed-phase capillary electrochromatography monolithic column, and belongs tothe field of analytical chemistry. By an in-situ polymerization method and an embedding method, the zeolite imidazate framework material ionic liquid organic polymer fixed-phase capillary electrochromatography monolithic column is synthesized by one step, zeolite imidazate framework materials are effectively fixed, an idea is provided for development of a novel capillary electrochromatography monolithic column, and chromatographic fixed-phase sources are greatly extended. The preparation method of the capillary electrochromatography monolithic column is simple, the fixed-phase material sources are wide, chromatographic performance is excellent, column efficiency is high, electroosmotic flow can be generated at the pH (potential of hydrogen) of 2.0-12.0, alkyl benzene series and phenol substances are rapidly and efficiently separated and detected, and the monolithic column has a great application potential in separation of complicated component substances.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, and in particular relates to the preparation and application of a zeolite imidazolate framework material ionic liquid organic polymer stationary phase capillary electrochromatography monolithic column. Background technique [0002] Zeolitic imidazolate frameworks (ZIFs) are formed by coordination of transition metal ions (Zn, Co) and imidazolates and their derivatives, and have a tetrahedral crystal structure similar to zeolite aluminosilicates, and are metal organic frameworks (MOFs) a subfamily of . There are many kinds of ZIFs, more than 170 kinds are known at present, such as ZIF-7, ZIF-8, ZIF-90, ZIF-67 and so on. ZIFs organically combine the advantages of zeolites and MOFs, which are stable, porous, large internal surface area, adjustable in structure and function, and are increasingly used in the field of chromatographic separation. The use of ZIFs as chromatographic stationary phases...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02B01D15/08B01D15/34
CPCB01D15/08B01D15/34G01N30/02
Inventor 陈子林毛振坤
Owner WUHAN UNIV
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