Soluble microneedle system and application thereof

A soluble, micro-needle technology, applied in the field of medicine, can solve problems such as safety risks, achieve good safety performance, improve therapeutic effects, and improve cosmetic effects

Inactive Publication Date: 2018-03-20
上海庚丰医药化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of PVA as a material for the preparation

Method used

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  • Soluble microneedle system and application thereof
  • Soluble microneedle system and application thereof
  • Soluble microneedle system and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of soluble microneedle system

[0036] Reverse mold preparation: mix the PDMS matrix and curing agent uniformly in a volume ratio of 10:1, leave it to stand to remove bubbles, pour it on the silicon microneedle, heat it on a microcomputer electric hot plate, and heat it at 80°C for 3 hours. It is cured until it is heated and solidified from a liquid with strong fluidity to a solid state, and then the film is removed to obtain a PDMS reversal mold with pinholes on the surface that matches the shape and number of the HA microneedle body.

[0037] Prepare polyvinylpyrrolidone (PVP) and / or hyaluronic acid (HA), as well as poloxamer 407 and carboxymethyl cellulose sodium (CMC-Na) three or four polymers according to the ratio shown in Table 1. The material mixture solution is injected into the PDMS reversal mold, the microneedle hole is filled to the full, placed in a closed container at 3 times the atmospheric pressure for 3 minutes, the filled microneedle m...

Embodiment 2

[0043] Example 2 Preparation of insulin-loaded soluble microneedles and comparison of sustained release effects

[0044] Reverse mold preparation: mix the PDMS matrix and curing agent uniformly in a volume ratio of 10:1, leave it to stand to remove bubbles, pour it on the silicon microneedle, heat it on a microcomputer electric hot plate, and heat it at 80°C for 3 hours. It is cured until it is heated and solidified from a liquid with strong fluidity to a solid state, and then the film is removed to obtain a PDMS reversal mold with pinholes on the surface that matches the shape and number of the HA microneedle body.

[0045] Add insulin powder to polyvinylpyrrolidone (PVP) and / or hyaluronic acid (HA), and a mixed solution of poloxamer 407 and carboxymethyl cellulose sodium (CMC-Na) three or four polymer materials (The weight percentages of these polymer materials in the mixed solution are shown in Table 1), inject the PDMS inversion mold, fill the micro-pinholes to full, and place ...

Embodiment 3

[0052] Example 3 Preparation of soluble microneedles containing propranolol hydrochloride and comparison of sustained-release effects

[0053] Add propranolol hydrochloride to polyvinylpyrrolidone (PVP) and / or hyaluronic acid (HA), as well as poloxamer 407 and carboxymethyl cellulose sodium (CMC-Na) three or four polymer materials In the mixed solution (the weight percentages of these polymer materials in the mixed solution are shown in Table 1), inject the PDMS inversion mold, fill the micro-pinholes to full, and place in a closed container at 3 times the atmospheric pressure for 3 minutes. The filled microneedle mold was placed in a desiccator to dry for 24 hours, and the microneedle was peeled from the PDMS reversal mold to obtain propranolol hydrochloride sustained-release microneedle III.

[0054] At the same time, use the same method to prepare propranolol hydrochloride microneedles for comparison:

[0055] 1. Add propranolol hydrochloride to PVP K30 Inject the PDMS reversal m...

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Abstract

The invention discloses a dissolvable microneedle system, which comprises a microneedle array and a substrate, and the microneedle array and the substrate both contain the following raw material components in weight percent: polyvinylpyrrolidone 0-80%, hyaluronic acid or its salt 0% ~80%, poloxamer 0~20%, sodium carboxymethylcellulose 0~10%; Wherein, the weight percent content of hyaluronic acid or its salt and polyvinylpyrrolidone is zero when different; Poloxamer and The weight percent content of sodium carboxymethyl cellulose is not zero at the same time. The invention also discloses the application of the above-mentioned soluble microneedle system in the preparation of cosmetics or slow-release medicines. The dissolvable microneedle system of the present invention can effectively delay the release rate of cosmetic components or medicines, obviously improve cosmetic or therapeutic effects, and has broad application prospects.

Description

Technical field [0001] The invention relates to the field of medical technology, in particular to a soluble microneedle system and its application. Background technique [0002] The barrier function of the stratum corneum is the biggest obstacle to the delivery of cosmetic ingredients or drugs to the skin. Microneedles can effectively penetrate the stratum corneum and improve the delivery efficiency of cosmetic ingredients or drugs into the skin. Therefore, they have broad application prospects in cosmetics and medical treatment. Repeated use of metal microneedles can easily cause the tip of the needle to break. If the broken tip remains in the skin, it may cause harm to the human body. In addition, if the metal microneedle is not thoroughly disinfected, it may cause cross-infection of diseases. The soluble microneedles are made of water-soluble polymer materials with good biocompatibility. This type of microneedle does not have the above-mentioned shortcomings of metal micron...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K8/86A61K8/81A61K8/73A61K47/10A61K47/38A61K47/32A61K47/36A61Q19/00A61L31/16A61L31/04A61L31/06A61K31/138A61P9/12A61K38/28A61P3/10A61M37/00
CPCA61K9/0021A61K8/731A61K8/735A61K8/8176A61K8/86A61K31/138A61K38/28A61K47/10A61K47/32A61K47/36A61K47/38A61L31/041A61L31/16A61L2300/204A61L2300/252A61M37/0015A61M2037/0023A61M2037/0061A61M2205/02A61M2210/04A61Q19/00C08L5/08C08L1/286C08L71/02C08L39/06
Inventor 于海荣那春艳
Owner 上海庚丰医药化工有限公司
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