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Construction and application of electrochemically controllable bacterial adhesion interface

A technology of bacterial adhesion and construction method, which is applied in the field of nanobiomedicine, can solve the problems of accelerating the aging process of underwater sensors, failure of medical operation operations, increasing fuel consumption of ships, etc., to achieve clinical application, shorten incubation time, interfere with small effect

Inactive Publication Date: 2021-07-16
SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The accumulation of surface microorganisms and macroscopic organisms may have serious consequences, including but not limited to failure of medical surgery operations, increased fuel consumption of ships, accelerated aging process of underwater sensors, etc.

Method used

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  • Construction and application of electrochemically controllable bacterial adhesion interface
  • Construction and application of electrochemically controllable bacterial adhesion interface
  • Construction and application of electrochemically controllable bacterial adhesion interface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A method for constructing an electrochemically controllable bacterial adhesion interface, comprising the following steps:

[0025] 1) Preparation of 3,5-bis(bis(pyridine-2-methyl)-aminomethyl)-4-hydroxyphenylpropanoic acid: put 550 mg paraformaldehyde and 2.8 g lutamine in 250 mL In a round bottom flask, add 15 mL of ethanol and 45 mL of water, then add 1.0 g of methyl p-hydroxyphenylpropionate and 1.4 mL of 1.0 M hydrochloric acid, and reflux for 24 h. The reaction mixture was cooled to room temperature and washed with saturated Na 2 CO 3 Neutralize to neutral, then extract the solution with excess chloroform. Na for organic phase 2 SO 4 After drying, chloroform was evaporated under reduced pressure. The crude product was purified by silica gel column chromatography (methanol:chloroform=5:95, v:v) to obtain a light yellow oily substance which was 3,5-bis(bis(pyridine-2-methyl)-aminomethyl)-4 -Hydroxyphenylpropionic acid. Its structure can be given by figure 2 ...

Embodiment 2

[0031] A method for constructing an electrochemically controllable bacterial adhesion interface, comprising the following steps:

[0032] 1) Preparation of 3,5-bis(bis(pyridine-2-methyl)-aminomethyl)-4-hydroxyphenylpropanoic acid: put 400 mg paraformaldehyde and 2.8 g lutamine in 250 mL In a round bottom flask, add 15 mL of ethanol and 45 mL of water, then add 1.0 g of methyl p-hydroxyphenylpropionate and 1.4 mL of 1.0 M hydrochloric acid, and reflux for 24 h. The reaction mixture was cooled to room temperature and washed with saturated Na 2 CO 3 Neutralize to neutral, then extract the solution with excess chloroform. Na for organic phase 2 SO 4 After drying, chloroform was evaporated under reduced pressure. The crude product was purified by silica gel column chromatography (methanol:chloroform=5:95, v:v) to obtain a light yellow oily substance which was 3,5-bis(bis(pyridine-2-methyl)-aminomethyl)-4 -Hydroxyphenylpropionic acid. Its structure can be given by figure 2 ...

Embodiment 3

[0038] A method for constructing an electrochemically controllable bacterial adhesion interface, comprising the following steps:

[0039] 1) Preparation of 3,5-bis(bis(pyridine-2-methyl)-aminomethyl)-4-hydroxyphenylpropanoic acid: put 600 mg paraformaldehyde and 2.8 g lutamine in 250 mL In a round bottom flask, add 15 mL of ethanol and 45 mL of water, then add 1.0 g of methyl p-hydroxyphenylpropionate and 1.4 mL of 1.0 M hydrochloric acid, and reflux for 24 h. The reaction mixture was cooled to room temperature and washed with saturated Na 2 CO 3 Neutralize to neutral, then extract the solution with excess chloroform. Na for organic phase 2 SO 4 After drying, chloroform was evaporated under reduced pressure. The crude product was purified by silica gel column chromatography (methanol:chloroform=5:95, v:v) to obtain a light yellow oily substance which was 3,5-bis(bis(pyridine-2-methyl)-aminomethyl)-4 -Hydroxyphenylpropionic acid. Its structure can be given by figure 2 ...

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Abstract

This patent proposes a new method for constructing a reversibly switched bacterial adsorption and release interface. The method is to modify the 3,5-bis(bis(pyridine-2-methyl)-aminomethyl)-4-hydroxyphenylpropionic acid complex of zinc onto the conductive interface to construct the bacterial adhesion interface, which can be quickly and efficiently Adsorbs bacteria, and after electrochemical reduction, it can become an anti-fouling interface and release bacteria. After adding Zn(NO3)2, the anti-fouling interface can be restored to the bacterial adhesion interface, so as to realize the controllable adjustment of the interface. The bacterial adhesion interface is simple in construction, convenient in use and reusable.

Description

technical field [0001] The invention relates to the field of nano-biomedicine, in particular to a method for constructing and using an electrochemically controllable bacterial adhesion interface. Background technique [0002] Bacteria are major pollutants in drinking water worldwide, especially in developing countries. Bacterial contamination can lead to serious health problems, including food poisoning and illness. According to research conducted by the International Water Organization, one out of every ten people in the world cannot obtain safe water, and more than one million people die from water-related diseases every year. In addition, biofouling has received great attention in recent years as a major economic and ecological problem. The accumulation of surface microorganisms and macroscopic organisms may have serious consequences, including but not limited to failure of medical surgery operations, increased fuel consumption of ships, accelerated aging process of und...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/02C12N13/00
CPCC12N1/02C12N13/00
Inventor 冀海伟王仁亮翟静冯蕾
Owner SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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