Method for detecting pulmonary embolism

Abstract

The invention discloses a method for detecting pulmonary embolism. Absolute counting of platelet microparticles in blood plasma is detected to serve as auxiliary diagnosis of the pulmonary embolism bythe method based on standard flow cytometry. Through ROC curve analysis, the critical value of the platelet microparticles for diagnosing the pulmonary embolism is 716.90 per mu l; the sensitivity and the specificity at the critical value are respectively 58.82 percent and 95.92 percent. The positive likelihood ratio is 14.41, and the negative likelihood ratio is 0.43. The positive predictive value is 93.75 percent, and the negative predictive value is 69.12 percent; the Youden's index is 54.74 percent. The method is a non-invasive operation and is low in cost, easy to perform and high in specificity, and can further screen patients with a positive D-dimer result clinically, improves diagnostic specificity, and can serve as an evaluation means before CTPA examination is performed on a patient with the pulmonary embolism, so that adverse reactions caused by the CTPA examination are reduced, and the burden of the patient is lightened.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a method for detecting pulmonary embolism. Background technique [0002] The incidence of pulmonary embolism (PE) occupies the third place among cardiovascular diseases. Due to the lack of specificity in the clinical manifestations of PE, about 80% of PTE are missed and misdiagnosed, resulting in PE becoming a human with high morbidity and mortality. major health problems. [0003] Studies have shown that clear and early diagnosis and appropriate treatment can reduce the mortality rate of PE to 2% to 8%. At present, the diagnosis of PTE mainly relies on CT pulmonary angiography to find the thrombus filling defect in the pulmonary artery. However, only 5% to 10% of suspected patients who underwent CTPA examination were true PE patients. In addition, CTPA examination is expensive and cannot be detected at any time, which delays the diagnosis of acute pulmonary embolism, and ...

AI Technical Summary

Problems solved by technology

Although D-dimer has high sensitivity, many diseases in the body (such as cardiovascular disease, surgery, tumor, infection and tissue necrosis, etc.) will lead to increased D-dimer, so its specificity is not high. If the result is positive, further CTPA examination is required

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