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A class of o-phenanthroline derivatives, zinc ion fluorescent probes and applications thereof

An o-phenanthroline and fluorescent probe technology, applied in the field of fluorescent ion probes, can solve problems such as weak coordination ability of sodium ions, and achieve the effects of strong anti-interference ability of other ions, broad application prospects and high sensitivity

Inactive Publication Date: 2020-04-17
SUZHOU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Such as: 15-crown-5 holes match the radius of sodium ions, but the ability to coordinate sodium ions is not strong, and there is no selectivity for sodium ions and potassium ions

Method used

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  • A class of o-phenanthroline derivatives, zinc ion fluorescent probes and applications thereof
  • A class of o-phenanthroline derivatives, zinc ion fluorescent probes and applications thereof
  • A class of o-phenanthroline derivatives, zinc ion fluorescent probes and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] (1) Recognition of zinc ions by phenanthroline derivatives substituted at the 3-position of 4-(2,2-distyryl)phenyl (hereinafter referred to as "3-DP")

[0064] Add 100μL of 5×10 to a 5mL volumetric flask -4 3-DP solution of M and 1.79×10 -4 M zinc ion aqueous solution 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150 μL, THF solution to constant volume. Detect the fluorescence spectrum of the above solution, see figure 2 . The addition of zinc ions made the fluorescence of 3-DP at 417nm gradually decrease, and a new emission peak appeared at 523nm, and the fluorescence peak gradually increased as the amount of zinc ions increased until the amount of zinc ions added reached 140 μL, that is, Zn 2+ The molar ratio with 3-DP is 1:2. Compared with the 3-DP solution without zinc ions, the addition of zinc ions enhanced the fluorescence of 3-DP about 34 times. On the basis of the above-mentioned fluorescence titration experiment, using the Benesi-Hildeb...

Embodiment 2

[0070] (1) 4-(2,2-distyryl)phenyl 5-substituted o-phenanthroline zinc ion fluorescent probe (hereinafter referred to as "5-DP") for the recognition of zinc ions

[0071] Add 100μL of 5×10 to a 5mL volumetric flask -4 M of 5-DP solution and 1.79×10 -4 M zinc ion aqueous solution 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150 μL, THF solution to constant volume. Detect the fluorescence spectrum of the above solution, see Figure 5 . The addition of zinc ions made the fluorescence of 5-DP at 392nm gradually decrease, and a new emission peak appeared at 513nm, and the fluorescence peak gradually increased with the increase of zinc ions until the amount of zinc ions added reached 140 μL, that is, Zn 2+ The molar ratio with 5-DP is 1:2. Compared with the 5-DP solution without zinc ions, the addition of zinc ions enhanced the fluorescence of 5-DP about 5 times. On the basis of the above-mentioned fluorescence titration experiment, using the Benesi-Hildebrand...

Embodiment 3

[0077] Recognition of zinc ions by pyrene 3-substituted o-phenanthroline derivatives (hereinafter referred to as "3-BP")

[0078] Add 100μL of 5×10 to a 5mL volumetric flask -4 3-BP solution of M and 1.79×10 -4M zinc ion aqueous solution 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150 μL, THF solution to constant volume. Detect the fluorescence spectrum of the above solution. The addition of zinc ions made the fluorescence of 3-BP at 440nm gradually decrease, and a new emission peak appeared at 533nm, and the fluorescence peak gradually increased as the amount of zinc ions increased until the amount of zinc ions added reached 140 μL, that is, Zn 2+ The molar ratio with 3-BP is 1:2.

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Abstract

The invention discloses a phenanthroline derivative, a zinc ion fluorescence probe and application thereof. The phenanthroline derivative can serve as the zinc ion fluorescence probe and is applied tothe fields of metal ion identification and detection. The phenanthroline derivative has a structure as shown in any one of formulas (I) to (II) (the formulas are as shown in the description), whereinR comprises any one of thienyl, carbazolyl, fluorenyl, pyrenyl and 4-(2,2-distyryl)phenyl. The phenanthroline zinc ion fluorescence probe has high selectivity and high sensitivity on zinc ions, can realize rapid detection of the zinc ions, has high selectivity and high capability of resisting other ion interference, provides a new method for designing the metal ion probe with high selectivity andsensitivity, and has wide application prospect in the field of metal ion detection.

Description

technical field [0001] The invention relates to a class of o-phenanthroline derivatives, in particular to a highly selective and highly sensitive o-phenanthroline zinc ion fluorescent probe and its application in metal ion identification and detection, belonging to fluorescent ion probes technology field. Background technique [0002] As a component of more than 200 metalloenzymes in the human body, zinc ions are directly involved in physiological processes such as cell development, reproduction, and tissue repair in the body, and play an important role in the processes of brain activity, gene transcription, and immune function in organisms. In recent years, the galvanizing industry and zinc-manganese batteries have become more and more widely used, and zinc pollution has become more and more serious. Therefore, the detection of zinc ions has important research significance. However, zinc ions have a stable d-electron configuration, and commonly used UV-visible spectroscop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64
CPCG01N21/6428G01N2021/6432
Inventor 梁作芹邹志扬王筱梅叶常青陈硕然
Owner SUZHOU UNIV OF SCI & TECH
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