Alginate wound surface restoring dressing and preparation method thereof

A technology of wound repair and alginate, which is applied in the fields of alginate rayon, pharmaceutical formula, rayon manufacturing, etc. It can solve the problems of accelerating wound healing, reduce the number of dressing changes and improve comfort

Inactive Publication Date: 2018-04-13
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the deficiencies of existing alginate dressings in the care of chronic and complicated wounds, and to

Method used

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  • Alginate wound surface restoring dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The alginate wound repair dressing adopts the following preparation process:

[0028] (1) Add the bioactive powder into the mixture of water and ethanol (volume ratio 1:1), and disperse the powder evenly to form a suspension;

[0029] (2) Immerse hydrophobically modified calcium alginate fibers in saturated KMnO 4 6min, and then washed with distilled water to obtain coarse alginate fiber;

[0030] (3) Immerse the above-mentioned coarse alginate fiber into the suspension and fully soak it, and spray the suspension evenly on the surface of the fiber, then centrifuge and dehydrate, soak the obtained wet fiber in the ethanol solution, centrifuge to remove the ethanol, and naturally Drying in the air, followed by vacuum drying at 60°C, the weight percent content of the finally obtained bioactive powder in the dressing is 10%;

[0031] (4) The fibers processed in the above 3) are cut into short fibers, and then made into non-woven fabrics through carding, net laying, and ac...

Embodiment 2

[0035] The alginate wound repair dressing adopts the following preparation process:

[0036] (1) Add the bioactive powder into the mixture of water and ethanol (volume ratio 1:1), and disperse the powder evenly to form a suspension;

[0037] (2) Immerse hydrophobically modified calcium alginate fibers in saturated KMnO 4 5min, and then washed with distilled water to obtain coarse alginate fiber;

[0038] (3) Immerse the above-mentioned coarse alginate fiber into the suspension and fully soak it, and spray the suspension evenly on the surface of the fiber, then centrifuge and dehydrate, soak the obtained wet fiber in the ethanol solution, centrifuge to remove the ethanol, and naturally Drying in the air, followed by vacuum drying at 80°C, the weight percent content of the finally obtained bioactive powder in the dressing is 15%;

[0039] (4) The fibers processed in the above 3) are cut into short fibers, and then made into non-woven fabrics through carding, net laying, and ac...

Embodiment 3

[0043] The alginate wound repair dressing adopts the following preparation process:

[0044] (1) Add the bioactive powder into the mixture of water and ethanol (volume ratio 1:1), and disperse the powder evenly to form a suspension;

[0045] (2) Immerse hydrophobically modified calcium alginate fibers in saturated KMnO 4 8min, and then washed with distilled water to obtain coarse alginate fiber;

[0046] (3) Immerse the above-mentioned coarse alginate fiber into the suspension and fully soak it, and spray the suspension evenly on the surface of the fiber, then centrifuge and dehydrate, soak the obtained wet fiber in the ethanol solution, centrifuge to remove the ethanol, and naturally Drying in the air, followed by vacuum drying at 70°C, the weight percent content of the finally obtained bioactive powder in the dressing is 5%;

[0047] (4) The fibers processed in the above 3) are cut into short fibers, and then made into non-woven fabrics through carding, net laying, and acu...

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Abstract

The invention discloses an alginate wound surface restoring dressing and a preparation method thereof. Alginate, honey and 45S5 bioactive glass are organically combined, and high hygroscopicity, hemostatic performance and pliability of alginate in caring a wound surface are brought into full play; antibacterial effect, analgesic effect and effect of secreting growth factor to promote wound healingof three functional materials including alginate, the honey and the bioactive glass presented during wound surface care are organic combined so as to generate synergistic wound caring effect, so thatoptimal caring of a wound is realized. In addition, after hydrophobic modification of alginate, ion exchange of the bioactive glass and the honey during wound caring is conducted slowly, so that thedressing can give wound caring efficacy to lasting play, dressing change times can be reduced, and comfort of a patient is improved. The preparation process of a composite material prepared by the dressing does not need special equipment and is mild in reaction condition, mature in technique and suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to the technical field of medical consumables, and specifically includes an alginate wound repair dressing and a preparation method thereof. Background technique [0002] A wound is a skin defect caused by mechanical, electrical, thermal, chemical or other factors or by a medical or physiological abnormality. Wounds can also be categorized by items such as pathology, location of injury, cause of injury, or wound color. Generally speaking, according to the length of healing time, it can be divided into acute wounds and chronic wounds. Wound healing refers to the complex process of regeneration and repair of body tissues after trauma. Taking the healing process of skin wounds as an example, it includes the stages of early wound inflammation, wound contraction, granulation tissue hyperplasia, and epidermal regeneration. Depending on the patient's own physical fitness and wound care conditions, the specific performance and duration...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/46A61L15/18A61L15/40A61L15/28D01F9/04D01F1/10D06M11/50D06M101/04
CPCA61L15/18A61L15/28A61L15/40A61L15/44A61L15/46D01F1/10D01F9/04D06M11/50D06M2101/04A61L2300/412A61L2300/404A61L2300/10C08L5/04A61L15/42A61L15/60A61L2400/12A61L2300/30A61L2300/112
Inventor 韦加娜陈锦涛熊亮
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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