Magnetic material used for pretreatment of to-be-detected drug material in aqueous solution and preparation method of magnetic material

Abstract

The invention discloses a magnetic material used for pretreatment of a to-be-detected drug material in an aqueous solution and a preparation method of the magnetic material. The preparation method ofthe magnetic material includes the following steps of: dispersing oleic acid-wrapped magnetic nanoparticles in an organic solvent, adding an aqueous solution of a surfactant so as to form an emulsion,and removing the organic solvent to obtain surfactant-wrapped magnetic nanoparticles; dispersing the surfactant-wrapped magnetic nanoparticles in water, adding a silica precursor and a porogenic agent, performing a reaction under an alkaline condition so as to form a silica layer on the surface of the magnetic nanoparticles and obtain the target magnetic material. Drug molecules in the aqueous solution can be adsorbed specifically through the magnetic material, and the concentrated drug molecules can be released into a solvent or solution required for analysis by utilizing the characteristicof easy separation of the magnetic material, so that the influence of other components in the initial to-be-detected material on the extraction recovery and detection sensitivity of the drug moleculesis reduced, and efficient pretreatment of the to-be-detected drug material in the aqueous solution is achieved.

Description

technical field [0001] The invention relates to a magnetic material used for pretreatment of aqueous solution drug test materials and a preparation method thereof, belonging to the field of physical evidence identification. Background technique [0002] At present, the situation of drug control in my country is severe. With the increase of drug types, the requirements for drug testing technology are constantly increasing, especially for the rapidity, sensitivity and specificity of drug testing methods. According to the form of drugs and the purpose of detection, different sample pretreatments are required for different types of drug samples to ensure the sensitivity and reliability of detection. At present, the pretreatment of drug samples in forensic science laboratories still mostly uses organic solvents for direct dissolution or organic solvent extraction. For most of the solid substances seized in drug-related cases, such as crystals, tablets, powders, etc., organic sol...

AI Technical Summary

Problems solved by technology

For most of the solid substances seized in drug-related cases, such as crystals, tablets, powders, etc., organic solvents are often used to directly dissolve them, which is easy to operate. and the amount of organic solvent used is relatively large, which is likely to cause environmental pollution and cause harm to the health of operators; for aqueous liquid test materials and plant test materials, it is necessary to use organic solvents to extract the components to be tested from the water phase, and sometimes it is necessary to Concentrate the water first and then extract it with an organic solvent to reduce the amount of organic solvent used. There are problems such as low recovery rate, emulsification, poor reproducibility, complicated operation process, and time-consuming extraction process.

[0003] Faced with the above problems, many analytical chemists have optimized or developed new drug sample pretreatment methods based on solvent extraction on the basis of traditional liquid-liquid extraction, but these achievements can only be applied in a specific system or some methods are still limited. In the research stage, it is not easy to automate and cannot be widely used in actual cases

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