Method for synthesizing rhodioloside based on microwave assistance and application of synthesized rhodioloside to anti-ageing preparation

A salidroside and microwave-assisted technology, which can be applied to medical preparations containing active ingredients, antidote, chemical instruments and methods, etc., can solve problems such as affecting the yield of salidroside, and achieve better feasibility, High yield and less inactivation effect

Inactive Publication Date: 2018-04-20
ZHEJIANG FORESTRY UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the above-mentioned process of synthesizing salidroside, there are the following disadvantages: in the step of preparing salidroside from benzyl salidroside, the common continuous hea...

Method used

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  • Method for synthesizing rhodioloside based on microwave assistance and application of synthesized rhodioloside to anti-ageing preparation
  • Method for synthesizing rhodioloside based on microwave assistance and application of synthesized rhodioloside to anti-ageing preparation
  • Method for synthesizing rhodioloside based on microwave assistance and application of synthesized rhodioloside to anti-ageing preparation

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Embodiment 1

[0030] A method based on microwave-assisted synthesis of salidroside, the method comprising the following preparation steps:

[0031] S01. Take pentaacetylated glucose 200, 60 g of p-hydroxyethylbenzaldehyde and dichloromethane and put them in a 2000 ml container, after mixing evenly, add 200 g of 4A molecular sieves to obtain a mixed raw material solution;

[0032] S02, the mixed raw material solution is placed under the temperature condition of 10 ℃, and the dichloromethane solution of anhydrous tin tetrachloride is slowly added dropwise, wherein contains solute anhydrous tin tetrachloride 134g, after reacting for 3 hours, obtain formula ( 1):

[0033]

[0034] S03. Add a reducing agent to obtain (1), add acetic acid solution and sulfuric acid solution successively after fully reacting, microwave heating to 110 ° C, after reacting for 55 minutes, the formula (2) is obtained:

[0035]

[0036] S04. Add a mixed solution prepared by sodium methoxide and methanol at a vol...

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Abstract

The invention discloses a method for synthesizing rhodioloside based on microwave assistance and application of the synthesized rhodioloside to an anti-ageing preparation and belongs to the field of drug synthesis. The method comprises the following steps: putting pentaacetylated glucose, p-hydroxyethyl benzaldehyde and dichloromethane into a container; adding a 4A molecular sieve to obtain a mixed raw material solution; storing the mixed raw material solution under the temperature condition of 10 DEG C and slowly dropwise adding a dichloromethane solution of anhydrous stannic tetrachloride; after reacting for 3h, adding a reducing agent; after sufficiently reacting, adding an acetic acid solution and a catalyst in sequence; after reacting or 50 to 60min, adding a mixed solution prepared from sodium methoxide and methanol according to the volume ratio of 2 to 1; after reacting, adding a decoloring agent and carrying out decoloring treatment for 10 to 30min; heating by microwaves and controlling the temperature to be 70 to 75 DEG C; extracting and purifying a rhodioloside crude product solution to obtain a rhodioloside fine product. The synthesis method provided by the invention hasthe advantage of high yield.

Description

technical field [0001] The invention belongs to the field of drug synthesis, and specifically relates to a method for synthesizing salidroside assisted by microwaves and the application of the synthesized salidroside in anti-aging preparations. Background technique [0002] Rhodiola is a perennial herb or subshrub of Crassulaceae. The whole plant can be used as medicine. Its stems, roots, and flowers are red in color. It is usually used as medicine and health care products. It has anti-fatigue and anti-hypoxia , anti-aging, anti-microwave radiation, promoting blood circulation and removing stasis, anti-virus, anti-tumor, stimulating the central nervous system and regulating endocrine and other pharmacological effects. Because salidroside is an effective pharmacological component in the Rhodiola plant, and as the supply of Rhodiola is in short supply, more and more scientific researchers are involved in the ranks of synthesizing and preparing salidroside. [0003] At present...

Claims

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Application Information

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IPC IPC(8): C07H1/00C07H15/18A61K31/7028A61K31/7048A61K31/715A61K31/704A61K31/375A61P39/06
CPCA61K31/375A61K31/7028A61K31/704A61K31/7048A61K31/715C07H1/00C07H15/18A61K2300/00
Inventor 杨胜祥况燚傅深渊
Owner ZHEJIANG FORESTRY UNIVERSITY
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