Method for synthesizing rhodioloside based on microwave assistance and application of synthesized rhodioloside to anti-ageing preparation

Abstract

The invention discloses a method for synthesizing rhodioloside based on microwave assistance and application of the synthesized rhodioloside to an anti-ageing preparation and belongs to the field of drug synthesis. The method comprises the following steps: putting pentaacetylated glucose, p-hydroxyethyl benzaldehyde and dichloromethane into a container; adding a 4A molecular sieve to obtain a mixed raw material solution; storing the mixed raw material solution under the temperature condition of 10 DEG C and slowly dropwise adding a dichloromethane solution of anhydrous stannic tetrachloride; after reacting for 3h, adding a reducing agent; after sufficiently reacting, adding an acetic acid solution and a catalyst in sequence; after reacting or 50 to 60min, adding a mixed solution prepared from sodium methoxide and methanol according to the volume ratio of 2 to 1; after reacting, adding a decoloring agent and carrying out decoloring treatment for 10 to 30min; heating by microwaves and controlling the temperature to be 70 to 75 DEG C; extracting and purifying a rhodioloside crude product solution to obtain a rhodioloside fine product. The synthesis method provided by the invention hasthe advantage of high yield.

Description

technical field [0001] The invention belongs to the field of drug synthesis, and specifically relates to a method for synthesizing salidroside assisted by microwaves and the application of the synthesized salidroside in anti-aging preparations. Background technique [0002] Rhodiola is a perennial herb or subshrub of Crassulaceae. The whole plant can be used as medicine. Its stems, roots, and flowers are red in color. It is usually used as medicine and health care products. It has anti-fatigue and anti-hypoxia , anti-aging, anti-microwave radiation, promoting blood circulation and removing stasis, anti-virus, anti-tumor, stimulating the central nervous system and regulating endocrine and other pharmacological effects. Because salidroside is an effective pharmacological component in the Rhodiola plant, and as the supply of Rhodiola is in short supply, more and more scientific researchers are involved in the ranks of synthesizing and preparing salidroside. [0003] At present...

AI Technical Summary

Problems solved by technology

However, in the above-mentioned process of synthesizing salidroside, there are the following disadvantages: in the step of preparing salidroside from benzyl salidroside, the common continuous heating method is easy to make palladium carbon be placed in a high temperature environment for a long time. And limit the catalytic activity of palladium carbon, and then affect the yield of salidroside

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