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Preparation and application of carboxyl-modified mesoporous silicon dioxide nanoparticles with reduction response

A technology of mesoporous silica and carboxyl group modification, which can be used in medical preparations with non-active ingredients, inorganic non-active ingredients, anti-tumor drugs, etc. The effect of drug release and reduction of drug side effects

Inactive Publication Date: 2018-05-04
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the sulfhydryl modification in the above-mentioned open documents is a simple pore modification, and the thiol modified in the pore mainly has two uses. One is to covalently load drugs such as 6-mercaptopurine with a sulfhydryl group. The second is to functionalize the sulfhydryl group into a disulfide bond, but at this time, the pore size will be further reduced after the disulfide bond modification, which will further reduce the drug loading capacity.

Method used

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  • Preparation and application of carboxyl-modified mesoporous silicon dioxide nanoparticles with reduction response
  • Preparation and application of carboxyl-modified mesoporous silicon dioxide nanoparticles with reduction response
  • Preparation and application of carboxyl-modified mesoporous silicon dioxide nanoparticles with reduction response

Examples

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Effect test

Embodiment 1

[0039] 1) Preparation of ethanol solution of mercapto-modified mesoporous silica nanoparticles:

[0040] Preparation of 25wt% (mass percent) cetyltrimethylammonium chloride (CTAC) aqueous solution: take 3.5g CTAC and dissolve it in 10.5ml water, stir vigorously at room temperature for 20min until clear;

[0041] Take 64ml of water, 10.5mL of ethanol, 10.4mL of 25wt% CTAC aqueous solution and stir vigorously at room temperature for 10min, add 4.125mL of triethanolamine, and continue vigorously stirring for 15min until clarification is used as the stock solution; 2 After the temperature is stabilized in an oil bath to 60°C under protection, then add a mixture of 1.454mL tetraethylorthosilicate (TEOS) and 0.1625mL mercaptopropyltriethoxysilane (MPTES) dropwise within 2 to 3 minutes under stirring. solution, continue to stir for 2 hours, centrifuge, and wash with ethanol twice; redisperse the above solution in ethanol solution containing 5mL hydrochloric acid (37wt%) and 45mL, reflu...

Embodiment 2

[0049] 1) Preparation of ethanol solution of mercapto-modified mesoporous silica nanoparticles:

[0050] Preparation of 25wt% (mass percentage) cetyltriethylammonium bromide aqueous solution: take 3.96g cetyltriethylammonium bromide and dissolve it in 10.5ml water, stir vigorously at room temperature for 20min until clear;

[0051] Take 64ml of water, 10.5mL of ethanol, 10.4ml of 5wt% hexadecyltriethylammonium bromide aqueous solution and stir vigorously at room temperature for 10min, add 2mL of sodium hydroxide, continue vigorously stirring for 15min until clarified and use as stock solution; take 20mL of stock solution Placed in a three-necked flask, under N 2 After the temperature is stabilized in an oil bath under protection, add a mixture of 1.454 mL tetramethyl orthosilicate and 0.165 mL mercaptopropyltrimethoxysilane dropwise within 2 to 3 minutes under stirring, continue stirring for 2 hours, and centrifuge , washed 2 times with ethanol; the above solution was redispe...

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Abstract

The invention discloses preparation and application of carboxyl-modified mesoporous silicon dioxide nanoparticles with reduction response, and belongs to the technical field of medicines. A preparation method disclosed by the invention comprises the following steps: (1) preparing an ethanol solution of hydrosulphonyl-modified mesoporous silicon dioxide nanoparticles; (2) preparing disulfide bond amino-modified mesoporous silicon dioxide nanoparticles; (3) preparing disulfide bond carboxyl-based mesoporous silicon dioxide nanoparticles. According to the preparation and the application of the carboxyl-modified mesoporous silicon dioxide nanoparticles with the reduction response, the carboxyl-modified mesoporous silicon dioxide nanoparticles are prepared in a mode of directly and mainly modifying disulfide bonds out of pores, the drug loading capacity cannot be reduced, the drug release can be effectively controlled, and the carboxyl-modified mesoporous silicon dioxide nanoparticles can be applied to the technical fields such as drug carriers.

Description

technical field [0001] The invention relates to mesoporous silicon dioxide nanoparticles, which belong to the technical field of medicine, in particular to the preparation and application of a carboxyl-modified mesoporous silicon dioxide nanoparticle with reduction response. Background technique [0002] The drug controlled release system can realize the targeted release of the drug at the lesion site, improve the efficacy of the drug, and reduce the toxic and side effects of the drug. An ideal drug controlled release system requires zero release of the loaded drug before reaching the target lesion site, and release after reaching the target target. [0003] Mesoporous silica nanoparticles (MSNs) have a wide range of applications in drug delivery systems, catalysis and adsorption, protein separation, etc., especially in drug delivery systems, showing incomparable advantages: large specific surface area (>900m 2 / g) and specific pore volume (>0.9cm 3 / g), adjustable p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K47/20A61P35/00
CPCA61K47/02A61K47/20
Inventor 刘明星王晚霞
Owner HUBEI UNIV OF TECH
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