Thermotropic hydrogel sustained-release veterinary drug injection for animal contraception and preparation method thereof

Abstract

The invention belongs to the field of pharmaceutical preparations, in particular to a thermotropic hydrogel sustained-release veterinary drug injection containing contraception effective components and a preparation method of the thermotropic hydrogel sustained-release veterinary drug injection containing the contraceptive effective components. The injection preparation comprises three parts of anamphiphilic block copolymer, the contraceptive effective components and a solvent together. For the amphiphilic block copolymer, generally polyethylene glycol forms a hydrophilic block, and degradable polyester forms a hydrophobic block. A water system of the amphiphilic block copolymer can be thermally gelatinized when the temperature increases and is fluid liquid at room temperature, and then semi-solid gel can be formed in situ at body temperature after injection and drug administration are performed, thereby being minimally invasive. The preparation is a first thermotropic hydrogel sustained-release preparation special for the animal contraception, and the sustained-release period for one injection can range from several weeks to several months; for the first time, the effective encapsulation of hydrophobic contraceptives is tried to be directly realized with the polymer water system without using organic solvents; the thermotropic hydrogel sustained-release veterinary drug injection for the animal contraception disclosed by the invention is simple in preparation process, low in materials cost and good in development prospects by being taken as the veterinary drug preparation.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a thermotropic hydrogel veterinary drug injection preparation containing contraceptive active ingredients and a preparation method thereof. Background technique [0002] In the animal farming industry, in order to improve the quality of farmed animals or their milk products, it is usually necessary to control animals for contraception and estrus. The means of contraception in mammals mainly include surgical and non-surgical methods. The surgical method is ligation of male animals, which is permanently effective but irreversible, and has problems such as poor animal compliance. Non-surgical methods include oral contraceptives, intrauterine rings, and subcutaneous implants. Oral contraceptives have problems such as easy missed doses, large side effects, and low bioavailability, while intrauterine rings and subcutaneous implants require artificial i...

AI Technical Summary

Problems solved by technology

However, because the solvent is an organic solvent, there is tissue toxicity, which greatly limits its application in the field of medical devices and veterinary preparations

[0008] Chinese patent (CN 101455644) describes a long-acting contraceptive microsphere for injection, which includes gestodene, estrogen and a biodegradable polymer, which can release the two active ingredients stably and synchronously over a long period of time , which solves the problems of large side effects and poor compliance of existing oral contraceptives

However, because it is an external dressing, the drug loading capacity is low, and it cannot achieve the effect of sustained release for a long time, so it cannot be used as a long-acting contraceptive preparation

[0010] None of the above patents or documents mentioned a long-acting sustained-release system for animal contraception that is minimally invasive, non-biotoxic, simple to prepare, and moderately costly.

Images