Abiraterone acetate tablets and preparation method thereof

Abstract

The invention belongs to the technical field of biological pharmacy and discloses abiraterone acetate tablets and a preparation method thereof. The abiraterone acetate tablets are combined with prednisone to treat metastatic castration resistant prostate cancer patients who receive docetaxel-combined chemotherapy in the past. The abiraterone acetate tablets are prepared from dehydroepiandrosteroneacetate as a raw material and auxiliary materials including 3-pyridyllithium, 3-pyridineboronic acid, hydroxypropylcellulose, sodium lauryl sulfate, starch, microcrystalline cellulose, cross-linked povidone, magnesium stearate and silica. The prepared abiraterone acetate tablets contain fewer impurities and are purer, allergic reactions caused by impurity doping in the preparation process are reduced, and receivers are increased.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, in particular to an abiraterone acetate tablet and a preparation method thereof. Background technique [0002] At present, prostate cancer is one of the most common malignant tumors in men. In recent years, the incidence of prostate cancer in my country has been on the rise, and most of them are in the middle and late stages when they are discovered. Studies have shown that androgens play an important role in the development of prostate cancer. Currently, first-line endocrine therapy (including surgery, chemical anti-androgen castration, or combined androgen deprivation therapy) is the standard treatment modality for newly diagnosed advanced prostate cancer, although this treatment is effective in the initial stage for most patients, However, after a median treatment time of 14 to 30 months, almost all patients will gradually develop into castration resistant prostate cancer (CRPC), w...

AI Technical Summary

Problems solved by technology

[0005] At present, the quality inspection of Abiraterone Acetate Tablets mainly stays in the stage of sensory evaluation and physical and chemical analysis, and the results of sensory evaluation are highly subjective and easily interfered by factors such as personal experience, gender, mental state, physical condition, and geographical environment, and the consistency is poor ; Although the physical and chemical analysis method has high detection accuracy and objective and reliable results, it will destroy the tested sample, the steps are cumbersome, the detection time is long, and the cost is high

Therefore, sensory evaluation and physical and chemical analysis methods are not conducive to the non-destructive and rapid detection of abiraterone acetate tablets

[0006] In summary, the existing problems in the prior art are: the existing technology for preparing abiraterone acetate is easy to be doped with impurities, which makes users prone to allergic reactions

Poor detection accuracy for drugs

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