Abiraterone acetate tablets and preparation method thereof

A technology of abiraterone acetate and acetic acid, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as cumbersome steps, easy doping with impurities, and poor consistency

Inactive Publication Date: 2018-06-01
XUZHOU COLLEGE OF INDAL TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, the quality inspection of Abiraterone Acetate Tablets mainly stays in the stage of sensory evaluation and physical and chemical analysis, and the results of sensory evaluation are highly subjective and easily interfered by factors such as personal experience, gender, mental state, physical condition, and geographical environment, and the consistency is poor ; Although the physical and chemical analysis method has high detection accuracy and objective and reliable results, it wil

Method used

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  • Abiraterone acetate tablets and preparation method thereof
  • Abiraterone acetate tablets and preparation method thereof
  • Abiraterone acetate tablets and preparation method thereof

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Embodiment Construction

[0103] In order to further understand the content, features and effects of the present invention, the following examples are given, and detailed descriptions are given below with reference to the accompanying drawings.

[0104] The structure of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0105]The composition and weight ratio of the abiraterone acetate tablet provided by the embodiment of the present invention consists of 30-50 abiraterone acetate, 0.4-2 hydroxypropyl cellulose, 1-4 sodium lauryl sulfate, and 40-40% microcrystalline cellulose. 60. Composition of crospovidone 1-8, magnesium stearate 0.5-2.5.

[0106] The working principle of the present invention is:

[0107] Such as figure 1 Shown, the preparation method of the Abiraterone acetate sheet that the embodiment of the present invention provides comprises the following steps:

[0108] S101: Using dehydroepiandrosterone acetate as raw material, carry out...

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Abstract

The invention belongs to the technical field of biological pharmacy and discloses abiraterone acetate tablets and a preparation method thereof. The abiraterone acetate tablets are combined with prednisone to treat metastatic castration resistant prostate cancer patients who receive docetaxel-combined chemotherapy in the past. The abiraterone acetate tablets are prepared from dehydroepiandrosteroneacetate as a raw material and auxiliary materials including 3-pyridyllithium, 3-pyridineboronic acid, hydroxypropylcellulose, sodium lauryl sulfate, starch, microcrystalline cellulose, cross-linked povidone, magnesium stearate and silica. The prepared abiraterone acetate tablets contain fewer impurities and are purer, allergic reactions caused by impurity doping in the preparation process are reduced, and receivers are increased.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, in particular to an abiraterone acetate tablet and a preparation method thereof. Background technique [0002] At present, prostate cancer is one of the most common malignant tumors in men. In recent years, the incidence of prostate cancer in my country has been on the rise, and most of them are in the middle and late stages when they are discovered. Studies have shown that androgens play an important role in the development of prostate cancer. Currently, first-line endocrine therapy (including surgery, chemical anti-androgen castration, or combined androgen deprivation therapy) is the standard treatment modality for newly diagnosed advanced prostate cancer, although this treatment is effective in the initial stage for most patients, However, after a median treatment time of 14 to 30 months, almost all patients will gradually develop into castration resistant prostate cancer (CRPC), w...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P35/00A61K9/20A61K47/38A61K47/20A61K47/32
CPCA61K31/58A61K9/2013A61K9/2027A61K9/2054
Inventor 刘郁刘连新刘春杰
Owner XUZHOU COLLEGE OF INDAL TECH
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