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A kind of children's gynecological lotion and preparation method thereof

A technology for gynecological lotion and children, applied in the medical field, can solve the problems of resistance to small molecular antibacterial agents, hidden dangers of human health and ecological environment, etc., and achieve the effects of no drug resistance, good biological safety, and improved antibacterial performance.

Active Publication Date: 2021-07-23
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of small molecule antibacterial agents can effectively improve the antibacterial effect of products, but small molecule antibacterial agents have drug resistance problems, which will bring great hidden dangers to human health and the ecological environment

Method used

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  • A kind of children's gynecological lotion and preparation method thereof
  • A kind of children's gynecological lotion and preparation method thereof
  • A kind of children's gynecological lotion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A kind of children's gynecological lotion, described product comprises the raw material of following mass percentage:

[0042]

[0043] Described chitosan derivative is the material shown in structural formula (1), and deacetylation degree is 90%, and molecular weight is 2 * 10 5 Da;

[0044] The stabilizer is a mixture of poloxamer 188 and polysorbate 20; the mass ratio of poloxamer 188 and polysorbate 20 in the mixture is 2:1.

[0045] A preparation method of children's gynecological lotion, comprising the steps of:

[0046] 1) take each raw material by the mass percentage described in claim 1, for subsequent use;

[0047] 2) mixing the chitosan derivative with part of sterile water to obtain the first mixed solution;

[0048] 3) mixing the stabilizer, vitamin B and part of sterile water to obtain the second mixed solution;

[0049] 4) Mix the first mixed solution with the second mixed solution, then add the remaining amount of sterilized water and stir evenly to...

Embodiment 2

[0051] A kind of children's gynecological lotion, described product comprises the raw material of following mass percentage:

[0052]

[0053] Described chitosan derivative is the material shown in structural formula (2), and deacetylation degree is 90%, and molecular weight is 10 6 Da;

[0054] The stabilizer is a mixture of poloxamer 407 and sorbitan oleate; the mass ratio of poloxamer 407 and sorbitan oleate in the mixture is 1:1.

[0055] A preparation method of children's gynecological lotion is the same as in Example 1 to obtain children's gynecological lotion B.

Embodiment 3

[0057] An antifungal infection product for children's skin, the product includes the following raw materials in mass percentage:

[0058]

[0059] Described chitosan derivative is the material shown in structural formula (3), and deacetylation degree is 50%, and molecular weight is 10 4 Da, carboxymethyl substitution degree is 100%;

[0060] The stabilizer is a mixture of poloxamer 407 and sorbitan oleate; the mass ratio of poloxamer 407 and sorbitan oleate in the mixture is 1:1.

[0061] A preparation method of children's gynecological lotion is the same as in Example 1 to obtain children's gynecological lotion C.

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Abstract

The invention discloses a gynecological lotion for children. The product comprises the following raw materials in mass percentage: chitosan derivative 5-30%; vitamin B 0.05-0.1%; stabilizer 0.1-5%; sterilized water 64.9-94.85% %; the present invention also discloses a preparation method of children's gynecological lotion; the chitosan derivative used in the present invention is chitosan, carboxymethyl chitosan or chitosan and carboxymethyl chitosan mixture through guanidine It is obtained by modifying base compounds and basic amino acids, which greatly improves the antibacterial performance of chitosan derivatives, so that it has more than 90% antibacterial performance against Escherichia coli, Staphylococcus aureus and Candida albicans. The antibacterial component used in the present invention is a polymer material, and as a children's gynecological lotion, it will not be transdermally absorbed, has good safety, and has no drug resistance.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a children's gynecological lotion and a preparation method thereof. Background technique [0002] Girls' external genitalia are immature, the vagina and urethra are exposed, the vaginal epithelium is thin, and the level of estrogen is low, without the protection of acid bacillus, they are prone to bacterial infection. Therefore, vulvitis is the most common pediatric gynecological disease. The main symptoms are itching, redness and swelling of the vulva, and purulent discharge. According to the statistics of Beijing Children's Hospital in 2007, girls' vaginitis accounted for about 60% of the children's gynecological diseases in the hospital. However, children's special gynecological lotion or related products are still blank clinically. [0003] At present, most adult gynecological antibacterial lotions use pure Chinese medicine preparations, or a combination of Chinese and Wes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61K9/08A61P31/04A61P31/10A61P15/00
CPCA61K9/0034A61K9/08A61K31/722A61K47/10A61K47/26A61K2300/00Y02A50/30
Inventor 牛忠伟吴曼蒋士冬
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI