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Absorbable film, absorbable insert and preparation method thereof

A technology for absorbing film layers and parts by mass, which is applied in medical science, prostheses, etc., can solve the problem of low fiber strength of absorbable implants, and achieve the effects of convenient shape adjustment, simple production method and increased safety.

Pending Publication Date: 2018-06-01
CHINESE TEXTILE ACAD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of this, the present invention provides an absorbable film layer, an absorbable implant and a preparation method thereof, and the main technical problem to be solved is that the fiber strength of the absorbable implant prepared by a quasi-electrospinning method is not high.

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0036] An embodiment of the present invention proposes a method for preparing an absorbable film layer, which includes:

[0037] Select the polyglycolide fiber of predetermined range length l;

[0038] Wherein, the size of the length l in the predetermined range may be greater than or equal to 1mm and less than or equal to 15mm, such as polyglycolide fibers of 3mm-10mm, and the preferred length is 4mm-6mm.

[0039] The first mass part m1 of polyglycolide fiber, the second mass part m2 of the adhesive polymer resin, and the third mass part m3 of the organic solvent are mixed to form a slurry, wherein the adhesive polymer resin can be Soluble in the organic solvent to form a binder, the polyglycolide fiber is insoluble in the organic solvent; the organic solvent includes acetone, chloroform, ethyl acetate, dimethylacetamide, dichloromethane, N- One of methylpyrrolidone and tetrahydrofuran. Adhesive macromolecular resin is soluble in described organic solvent, and described adh...

Embodiment 1

[0054] Use 3g of polyglycolide fiber with a length of 6mm, add it to ethyl acetate solvent, the ratio of polyglycolide fiber to ethyl acetate is 1:50, and beat in a high-speed stirring device with a beating speed of 25000r / min , and the beating time is 10 minutes to form a slurry. Add polylactic acid resin to ethyl acetate to prepare adhesive, and the mass ratio of polylactic acid resin to polyglycolide fiber is 1:50. Mix the slurry and binder and continue to add ethyl acetate solvent until the mass ratio of polyglycolide fiber and ethyl acetate solvent is 1:1500, stir at a high speed, the stirring speed is 15000r / min, and finally use 10cm 2 The circular gauze net is used to make it into a film, the thickness is 280μm, and the weight is 30g / m 2 .

Embodiment 2

[0056] Use 5g of polyglycolide fiber with a length of 6mm, add it to the ethyl acetate solvent, the ratio of polyglycolide fiber to ethyl acetate is 1:70, and beat in a high-speed stirring device with a beating speed of 20000r / min , and the beating time is 12 minutes to form a slurry. Add polylactic acid resin to ethyl acetate to prepare adhesive, and the mass ratio of polylactic acid resin to polyglycolide fiber is 1:60. Mix the slurry and binder and continue to add ethyl acetate solvent until the mass ratio of polyglycolide fiber and ethyl acetate solvent is 1:2000, stir at a high speed, the stirring speed is 13000r / min, and finally use 10cm 2 The square gauze mesh is used to make it into a film, the thickness is 500μm, and the weight is 50g / cm 2 .

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Abstract

The invention relates to an absorbable film, an absorbable insert and a preparation method thereof, relates to the technical field of absorbable inserts, and mainly solves the technical problem that the fiber strength of the absorbable insert prepared by an electrostatic spinning method is not high. The preparation method of the absorbable film comprises the following steps: selecting polyglycollide fiber with the preset range length of 1; mixing m1 parts of polyglycollide fiber, m2 parts of adhesive macromolecule resin and m3 parts of an organic solvent to form a sizing agent, wherein the adhesive macromolecule resin can be dissolved into the organic solvent to form an adhesive; and forming the sizing agent on a gauze net to prepare and form the absorbable film. Compared with the prior art, the strength of the absorbable film is relatively high, the manufacturing technology is simple, the thickness and shape are convenient to adjust, the absorbable film is softer by compared with a fabric patch, the absorbable film is light and thin and small in insert amount, few foreign matters are inserted into the body of a patient as an absorbable patch, and the pain and discomfortableness ofthe patient can be alleviated.

Description

technical field [0001] The invention relates to the technical field of absorbable implants, in particular to an absorbable film layer, an absorbable implant and a preparation method thereof. Background technique [0002] The damage of tissues (such as muscle and bone tissue) usually needs to be treated and repaired by surgical operation, and such repair is realized by suturing the damaged tissue and fitting absorbable implants into the damaged tissue. Absorbable implants can provide structural support to damaged tissue, and they can serve as a substrate on which cells can grow to facilitate healing and complete organ tissue regeneration. [0003] At present, absorbable implants, such as the preparation methods of absorbable membranes, mainly include the following types. One is to formulate a composition with collagen and / or silk fibroin and polylactic acid and / or polycaprolactone according to the mass percentage , using the electrospinning technology to prepare the absorbab...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/18A61L27/50
CPCA61L27/18A61L27/50A61L27/58C08L67/04
Inventor 崔华帅史贤宁黄庆吴鹏飞
Owner CHINESE TEXTILE ACAD
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