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Preparation technology of Yishen granules

A preparation process and granule technology, applied in the field of preparation of Yishen granules, can solve problems such as loss of effective components, and achieve the effects of improving effective active components, avoiding a large amount of loss, and avoiding loss.

Inactive Publication Date: 2018-06-08
林凡友
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant found in the pharmaceutical process that there is a defect in the extraction process of the drug that the active ingredient is lost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A preparation process for Yishen Granules, comprising the steps of:

[0020] Take 250g of fermented Cordyceps powder, 250g of Ganoderma lucidum, and 50g of medlar;

[0021] Take the fermented Cordyceps fungus powder, add 5 times the weight of water, soak for 30 minutes, extract the volatile oil by distillation, extract for 3 hours, collect the volatile oil, then add absolute ethanol accounting for twice the volume of the raffinate to the raffinate, and reflux to extract two 2 hours for the first extraction and 1 hour for the second extraction. During the extraction process, the temperature is controlled at 50°C and the microwave power is 500W. Filter separately, combine the filtrates, recover ethanol by vacuum rotary evaporation, and then concentrate to 1.35-1.40g / ml of extract, finally mixed with volatile oil to obtain component A;

[0022] Crush Ganoderma lucidum, then grind it into fine powder, pass through a 200-mesh sieve, spread it into a flat layer with a thick...

Embodiment 2

[0027] A preparation process for Yishen Granules, comprising the steps of:

[0028] Take 250g of fermented Cordyceps powder, 250g of Ganoderma lucidum, and 50g of medlar;

[0029] Fermented Cordyceps powder was extracted twice with 60% ethanol, each time adding 8 times the amount of 60% ethanol, each time for 12 hours, combined the extracts, filtered, and the filtrate was decompressed to recover ethanol, then concentrated under reduced pressure to a density of 1.20~ 1.25g / ml clear paste; decoct Ganoderma lucidum with water twice, add 8 times the amount of water each time, decoct for 2 hours for the first time, and decoct for 1.5 hours for the second time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to Clear ointment with a density of 1.05~1.10g / ml; Lycium barbarum is extracted twice with 70% ethanol, each time adding 5 times the amount of 70% ethanol, each time for 48 hours, the filtrate is combined, filtered, and the filtrate is decompre...

Embodiment 3

[0032] The extraction process of comparative example 1-2: compared with embodiment 2, the adenosine content in the product of embodiment 1 has improved by 11.3%, mannitol has improved by 6.7%, wolfberry polysaccharide has improved by 23.9%, sterol, saponin, amino acid Active components such as fritillaria and fritillary base substances are also greatly improved; after testing, the content of Ganoderma lucidum polysaccharides in component B of Example 1 is 913.4mg, and the content of Ganoderma lucidum polysaccharides in the Ganoderma lucidum extract clear paste of Example 2 is 607.2mg, Increased by 50%.

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PUM

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Abstract

The invention belongs to the technical field of medicine extraction and processing and discloses a preparation technology of Yishen granules. The technology comprises the steps as follows: step 1) weighing of raw materials, step 2) preparation of a component A, step 3) preparation of a component B, step 4) preparation of a component C and step 5) preparation of the granules. Animal tests indicatethe Yishen granules prepared with the preparation technology have the sleep helping effect superior to that of existing preparations, and effective active ingredients in medicines are substantially improved.

Description

technical field [0001] The invention belongs to the technical field of medicine extraction and processing, and in particular relates to a preparation process of Yishen Granules. Background technique [0002] Yishen Granules are composed of fermented Cordyceps fungus powder, Ganoderma lucidum and Lycium barbarum. It was designed by Mr. Qiu Chenbo, a famous pharmacy expert and senior engineer. It was trial-made into health food in early 1992 and was approved by Guangdong Provincial Food Hygiene Inspection Institute as an official standard. The product The name is Oriental God Grass. Because the product has obvious relieving effect on fatigue, neurasthenia, soreness of the waist and knees, nocturia, impotence, irregular menstruation, etc., it is sold well in Hong Kong, Macao, Singapore, Thailand and other places. Animal pharmacological studies conducted by Guangzhou College of Traditional Chinese Medicine and Hubei College of Traditional Chinese Medicine have proved that this ...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/16A61P25/20A61K36/068A61K36/074
CPCA61K36/068A61K9/1623A61K36/074A61K36/815A61K2236/10A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 林祥宇辛奇许莹
Owner 林凡友
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