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Preparation method of nanometer hybrid particles, and nanometer hybrid particles and nanometer drug which are produced using preparation method

A hybrid particle and nano technology, which is applied in the directions of drug combinations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems such as the inability to completely effectively prevent the early leakage of drug molecules, and ensure the reducibility. Responsive release, prevent premature leakage, good repeatability

Active Publication Date: 2018-06-08
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More importantly, when used as a drug carrier, the sparse polymer network structure in this type of organic covalently cross-linked micelles cannot completely effectively prevent the early leakage of drug molecules during the in vivo circulation.

Method used

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  • Preparation method of nanometer hybrid particles, and nanometer hybrid particles and nanometer drug which are produced using preparation method
  • Preparation method of nanometer hybrid particles, and nanometer hybrid particles and nanometer drug which are produced using preparation method
  • Preparation method of nanometer hybrid particles, and nanometer hybrid particles and nanometer drug which are produced using preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Dissolve 600mg of poloxamer F127 (non-ionic surfactant polyoxyethylene polyoxypropylene ether block copolymer) and 30mg of curcumin (Cur, hydrophobic drug molecule) in 10mL of ethanol, and add 10mL to ionized water. After vacuum rotary evaporation to remove all ethanol to form a film, add preheated deionized water, hydrate the film until redissolved, and obtain Cur-F127 600 Micellar based aqueous solution. 10mL Cur-F127 600 Transfer the micellar-based aqueous solution to a beaker and add 50 μL NH 4 OH and 1mL MPTMS (silane coupling agent), stirred at room temperature for 24h to obtain an aqueous solution of silicone and micellar base. Transfer the stirred aqueous solution to a dialysis bag with a molecular weight cut-off of 14,000, and replace the dialysis water every 4 to 6 hours, and dialyze for more than 24 hours to remove NH 4 OH and MPTMS to obtain silicone and micellar-based nano-hybrid particles (Cur-F127 600 -MPTMS 1000 ).

Embodiment 2

[0040] The implementation method and basic formula are the same as in Example 1, only the type of non-ionic block copolymer poloxamer is changed to P123, the quality is changed to 800mg, and the type of hydrophobic drug is changed to polytaxel (DTX) , the NH 4 The amount of OH and MPTMS added was changed to 100 μL and 600 μL, respectively. Finally, the nano-hybrid particles (DTX-P123 800 -MPTMS 600 ).

Embodiment 3

[0042] The implementation method and basic formula are the same as in Example 1, only changing the type of non-ionic block copolymer poloxamer to F108, changing the quality to 200mg, and changing the NH 4 The amount of OH and MPTMS added was changed to 25 μL and 200 μL, respectively. Finally, the nano-hybrid particles (Cur-F108 200 -BTES 200 ).

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Abstract

The invention relates to a preparation method of nanometer hybrid particles. The preparation method comprises following steps: 1, nonionic surfactant polyoxyethylene polyoxypropylene ether segmented copolymer and a hydrophobic medicament molecule are dissolved in an organic solvent, and rotary evaporation is adopted to remove the organic solvent completely so as to obtain film; 2 deionized water is added into the film, and redissolving is carried out so as to obtain a micelle based aqueous solution; ammoniacal liquor and silane coupling agent are added into the micelle based aqueous solution,and reaction is carried out at room temperature so as to obtain an organosilicon and micelle based aqueous solution; 4, dialysis is adopted for purifying of the organosilicon and micelle based aqueoussolution so as to obtain organosilicon and micelle based nanometer hybrid particles. The invention also provides the nanometer hybrid particles prepared through the preparation method. The inventionalso provides a nanometer drug used for treating tumor. The preparation method is capable of realizing carrying of hydrophobic drug molecules, preventing in advance leakage of drugs in vivo circulation effectively, and ensuring the reduction responsive release of drugs in tumor tissue.

Description

technical field [0001] The invention relates to the field of nano-biomedicine, in particular to a method for preparing nano-hybrid particles and the nano-hybrid particles and nano-medicine obtained therefrom. Background technique [0002] In recent years, using the self-assembly behavior of amphiphilic block copolymers in water, hydrophobic chemotherapeutic drugs with therapeutic functions and functional inorganic nanoparticles with diagnostic functions are carried in their hydrophobic cores to realize the integration of tumor diagnosis and treatment. Causing the attention of researchers (Adv.Drug Delivery Rev.,2011,63,131-135; Adv.Mater.,2015,27,2627-2634; J.Mater.Chem.B,2014,2,4237-4249; Angew Chem.Int.Ed., 2017, 56, 6712-6733; Angew.Chem.Int.Ed., 2016, 55, 11791-11796). However, due to the existence of the critical micelle concentration, once the pre-formed micellar structure is diluted below its critical micelle concentration value, it will be cleaved, resulting in the ...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/54A61K47/10A61K31/337A61K31/12A61P35/00
CPCA61K31/12A61K31/337A61K47/10
Inventor 李永生牛德超何健平
Owner EAST CHINA UNIV OF SCI & TECH
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