The invention provides a
cell manipulation method based on a thin film
resonator and a microchip, and the
cell manipulation method comprises the steps: arranging a liquid containing cells on a thin film of the thin film
resonator, and driving the thin film to vibrate according to a preset
resonance mode; and a vortex field is formed in the liquid through film
resonance, and the cells are dragged to move towards a stress
balance point of the vortex field above an antinode, so that the patterning control of the cells is realized. According to the invention, the
resonance mode of the thin film
resonator is controlled through the driving frequency of the
electric signal to manipulate cells, so that the
cell manipulation speed and the cell manipulation precision are improved; meanwhile, an
eddy current field is generated through resonance to realize cell manipulation, direct contact with cells is avoided, the original state of the cells can be kept, and unnecessary
cell stimulation and damage are avoided; and finally, array manufacturing of the microchip is realized by adopting a micromachining process, parallel manipulation of a large number of cells can be realized, and the
cell patterning complexity and manipulation efficiency are improved.